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Monosubstituted naphthoxylosides have been shown to function as substrates for, and inhibitors of, the enzyme β4GalT7, a key enzyme in the biosynthetic pathway leading to glycosaminoglycans and proteoglycans. In this article, we explore the synthesis of 16 xyloside analogues, modified at two different positions, as well as their function as inhibitors of and/or substrates for the enzyme. Seemingly

The rapid development of urban retail companies brings new opportunities to the Chinese economy. Due to the spatiotemporal heterogeneity of different cities, selecting a business location in a new area has become a challenge. The application of multi-source geospatial data makes it possible to describe human activities and urban functional zones at fine scale. We propose a knowledge transfer-based

Human complement component C4 was irreversibly inactivated by low concentrations of methylamine at slightly alkaline pH. The inactivated C4 molecules lost the ability to bind to EAC1 cells but retained th capacity to participate in the formation of classical pathway C3 convertase in the fluid phase. 14C-methylamine was incorporated into the alpha-chain at a ratio of 1 mol methylamine per mol C4.

The successful construction of any well-functioning structure is dependent on a good understanding of the ground on which it lies. Several methods and techniques have been developed to model subsurface conditions and properties with the purpose of gaining comprehensive knowledge of geological conditions. Seismic refraction presents a geophysical method of subsurface investigation capable of provid

This article explores complementary currencies (CC) that work on the basis of community credit schemes in Argentina, a country often referred to as a laboratory in terms of monetary exploration. In contrast to alternative community-based monetary systems created in the global North, CC developed in the global South usually pursue the creation of supplementary currency circulation in order to addre

Vår forskning tar upp hur hållbara framtider förstås, förverkligas och motsätts. Vi studerar flera visioner om hållbar framtid, maktrelationerna de är inbäddade i och deras transformativa potential. Vårt arbete täcker ett brett spektrum av sektorer, såsom skogsbruk, stål och plast, och en mängd olika aktörer, från fossila bränslen, petrokemisk och tung industri till gräsrotsorganisationer, aktiviOur research addresses how sustainable futures are understood, enacted and resisted. We study multiple visions of sustainable futures, the power relations they are embedded in, and their transformative potentials. Our work covers a broad range of sectors, such as forestry, steel and plastics, and a variety of actors, from fossil fuels, petrochemical and heavy industries to grassroots organisation

Popular Abstract in English The work presented here is about methods that will enable more precise estimates of soil and rock parameters related to seismic hazard mapping, in particular when resources are limited. This will allow for evaluating the seismic risk in countries where earthquakes are frequent and large budgets are not available. Particularly, the study of ground response due to the ene

Introduction The aim of this study is to determine the locations for school construction in two isolated mountainous communities in Gorno-Badakhshan Autonomous Oblast (GBAO) – Khorog and Porshnev towns. In recent decades, this region has become increasingly vulnerable to natural disasters. A major contributing factor to this vulnerability is the fact that very little land is available for human se

English (French summary below)Is it still possible to speak of authority other than in negative terms? In particular, to speak of exercising authority in religious institutions? I believe so. It is essential to exercise authority, also in religious institutions. But this exercise is not a simple matter. I propose to reflect on the question from four perspectives. The first is inspired by Martin Lu