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Environmental pollution is a significant concern for scientists, practitioners, authorities and the society. Among the various pollutants, chlorinated solvents pose a considerable risk to our groundwater resources. These hazardous chemicals, often used in industrial processes, can contaminate soil and water, posing a threat to both human health and ecosystems. Detecting and tracking the spread of
BACKGROUND: Bisphosphonates have profound effects on bone physiology, and could modify the process of metastasis. We undertook collaborative meta-analyses to clarify the risks and benefits of adjuvant bisphosphonate treatment in breast cancer.METHODS: We sought individual patient data from all unconfounded trials in early breast cancer that randomised between bisphosphonate and control. Primary ou
Delirium is a serious and common condition in the intensive care unit (ICU), which affects 30-50 % of the patients and is associated with increased mortality and morbidity in the context of long-term outcomes. No evidence-based treatment for delirium exists, and currently, delirium is mainly treated pharmacologically with haloperidol, a typical antipsychotic agent. The “Agents Intervening against
Room acoustic simulations are an important tool, both for design of spaces with satisfactory acoustics and for use in virtual reality experiences. Auralization of acoustic simulations are becoming more and more important in the context of Virtual and Augmented reality (VR and AR respectively), as the technology is used more and more in healthcare, culture and research. In this work, ray tracing si
Insect behaviours, such as host and mate selection, are often mediated by chemical cues. The chemical cuesare detected by large and rapidly evolving families of chemoreceptors which include odorant receptors (ORs),gustatory receptors (GRs) and ionotropic receptors (IRs). In this thesis, I used a model system of beetle(Coleoptera) species to study the functional evolution of insect ORs, their ligan
A Warehouse Management System (WMS) is a software that tracks and manages warehouse activities. The first WMS was introduced in 1975 and today the WMS market is valued at over USD 3 billion. Most warehouses use one as quality assurance becomes unlikely plausible without software support. This thesis focuses on Company X, who are the third-largest manufacturer by revenue in their industry and a
Kemira Kemia AB produces a water treatment chemical named ”PIX-Sulfate”, where “PI” stands for “poly iron x”, and the “x” represents a conjugate ion, such as chloride or sulfate, in this case, sulfate. The main process for producing PIX Sulfate at Kemira’s plants today is to dissolve magnetite in diluted sulfuric acid and to oxidize the resulting liquid using oxygen. Currently, this process is car
Currently, policy makers put high attention in supplying global energy demand by focusing on 2°C policy; global temperature anomaly based on the global mean temperature of pre-industrial era (13.7°C). How to keep the 2°C policy at global scope is the main question in climate framework. It is widely believed that primary energy resources (mainly coal, oil and natural gas) with focus on shale gas re
Background: Intravesical instillation of bacillus Calmette-Guérin (BCG) is an accepted strategy to prevent recurrence of non–muscle-invasive bladder cancer (NMIBC) but associated with significant toxicity. Objective: NIMBUS assessed whether a reduced number of standard-dose BCG instillations are noninferior to the standard number and dose in patients with high-grade NMIBC. Design, setting, and par
Background: Cardiovascular autonomic dysfunction is a multifactorial disorder manifested as orthostatic hypotension (OH) and postural orthostatic tachycardia syndrome (POTS). OH has been associated with an increased risk of cardiovascular disease (CVD), and the underlying mechanisms are not fully understood and explored.Aims and methods: Project I: We aimed to discover protein biomarkers related t
The research area of climate field reconstructions has developed strongly during the past 20 years, motivated by the need to understand the complex dynamics of the earth system in a changing climate. Climate field reconstructions aim to build a consistent gridded climate reconstruction of different variables, often from a range of climate proxies, using either statistical tools or a climate model
Deoxygenation, i.e. loss of oxygen from the oceans, often considerably influences the aquatic organisms and the wholeecosystem and changes biogeochemical cycles. It results in increasing bottom areas of hypoxia (<2 mg/l dissolved oxygen),which has been primarily attributed to global warming and increased eutrophication. It is vital to study the present-dayanthropogenically-induced environmental ch
Wind power developments in cold and icing conditions pose new challenges to the wind power industry. Icing of wind turbines cause safety hazards, production losses and increased loads. This means that there is a need to develop a technique to quantify the icing climatology and corresponding eects on wind turbines to enable large scale wind power developments in the windy, sparesly populated areas
This thesis deals with the international rules regarding passenger liability on an international aircraft. The focus will be the carrier's liability toward passengers on an aircraft. The purpose is to give an account of the common international rules and to clarify the problems with interpretation of the passenger liability article. I will focus on the Montreal Convention of 1999, which is the
Att mäta framgång i byggprojekt idag kan vara svårt. Dels att hitta en samsyn på vad framgång är dels hur man ska mäta framgång. Genom den forskning som finns inom området kan man konstatera att det är äldre metoder som används än idag för att mäta framgång. Dessa metoder har även modifierats med tiden och bildat nya metoder. De vanligaste områdena att mäta för att förstå framgång i forskning är tMeasuring success in construction projects today can be difficult—partly due to the lack of consensus on what success is, and partly due to the challenge of how to measure it. Existing research shows that older methods are still used to measure success, though many of these have been modified over time and evolved into new approaches. The most common aspects evaluated in research when measuring su
BACKGROUND: Minimally invasive surgery is rapidly expanding globally, yet there is insufficient knowledge of how to scale this technology safely and equitably across diverse health systems. We aimed to identify health-system factors associated with safe implementation of minimally invasive surgery globally, using minimally invasive cholecystectomy as a tracer procedure.METHODS: We conducted a mult
Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of
