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Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. As a consequence, our knowledge of the actual immunopathological events in real patient tissues is
This dissertation deals with memory, recognition and solidarity in the Nowa Huta district of Kraków, Poland. Nowa Huta was founded as an independent, socialist model town in 1949, together with the large Lenin Steel Plant, and was incorporated into Kraków in 1951. In the 1980s the steel plant and district became one of the main centers of the oppositional Solidarity movement in Poland. Situated be
The work presented in this thesis has aimed to improve the knowledge about the groundwater occurrence in different geological conditions in Mozambique. The main focus in this study has been on the understanding of hydrogeological conditions in area with little background information by use of geophysical investigation. The lack of background information is a problem in many countries because the
The objective of this thesis is to investigate the synthesis of well-defined polymer nanohybrid materials bearing desirable functionality via surface-initiated atom transfer radical polymerization (SI-ATRP) for potential bioapplications.SI-ATRP is an excellent controlled radical polymerization (CRP) method for the synthesis of polymer nanohybrid by growing polymer brushes (chains) from an interfac
Background: Prostate-specific antigen (PSA) measurement in midlife predicts long-term prostate cancer (PCa) mortality among white men. Objective: To determine whether baseline PSA level during midlife predicts risk of aggressive PCa in black men. Design, setting, and participants: Nested case-control study among black men in the Southern Community Cohort Study recruited between 2002 and 2009. A pr
Nature-based tourism in the fragile Arctic environments is emerging as a major environmental concern, mainly due to extreme seasonality in these locations, the lack of suitable infrastructures and planning, and its interference with fragile ecosystems. In Iceland tourism has increased exponentially during the past decades, causing more environmental impacts on the country's natural recourses. Hiki
Background: The optimal surgical excision margins are uncertain for patients with thick (>2 mm) localised cutaneous melanomas. In our previous report of this multicentre, randomised controlled trial, with a median follow-up of 6·7 years, we showed that a narrow excision margin (2 cm vs 4 cm) did not affect melanoma-specific nor overall survival. Here, we present extended follow-up of this cohort.
Abstract: HLA‐DR2 is negatively associated with insulin‐dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2‐positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched controls. HLA‐DRB, ‐DQA and ‐DQB were determined by Taq I restriction fragment length polymorphism analysis. Amplification by polymerase chain reaction
Popular Abstract in Swedish Hur gick det till när det svenska riket expanderade norrut och införlivade Hälsingland? Denna bok är uppställd som en generalhypotes över denna långt utdragna process, som tar sin utgångspunkt i den samhälleliga kollaps som är skönjbar under 500-talet. De inhemska maktstrukturer som gradvis byggdes upp efteråt kom under medeltidens inledande århundraden att få känna på In which way did the power structures of central Sweden expand into the territories north of the forest Ödmården during the Middle Ages? This text reads like a general hypothesis for this process, which attempts to incorporate all relevant elements in the Medieval landscape of power. The study area chosen is the province of Hälsingland. The chronological take-off is the 6th century AD, when settle
Popular Abstract in Swedish Många fåglar flyttar regelbundet långa sträckor mellan sina häckningsplatser och vinterkvarter. På rastningsplatser längs flyttningsvägen stannar fåglarna upp och äter, för att lagra upp de energi-lager de behöver som bränsle när de flyger. Vissa flyttfåglar lägger på sig så mycket bränsle (energi), mestadels som fett, att de dubblar sin kroppsvikt. Det lagrade bränslet
Construction in rock is associated with risks because knowledge of the geology and ground conditions is limited. Unforeseen rock conditions involve a large risk to the project and can in the end entail delays and extra costs. To minimize the risks, an optimized pre-investigation program has to be conducted where essential information is gathered in order to make the best decisions throughout the c
Load problems in electricity markets occur both on the supply and demand side and can have technical, economic and even political causes. Commonly, such problems have been solved by expanding production and/or distribution capacity, importing electricity or by load management. Load management is a techno-economic measure for harmonizing the relations between supply and demand sides, optimizing pow
Aim: The Eurasian otter (Lutra lutra) is a flagship species for global freshwater ecosystems. As one of the most widely distributed Palearctic mammals, the otter used to inhabit most provinces in China. However, after decades of relentless hunting and habitat degradation, the Sanjiangyuan Region is now one of last strongholds for this species in China. Currently, there still remains an enormous kn
In Europe, willow (Salix spp.) trees have been used commercially since the 1980s at a large scale to produce renewable energy. While reducing fossil fuel needs, growing short rotation coppices (SRCs), such as poplar or willow, may have a high impact on local air quality as these species are known to produce high amounts of isoprene, which can lead to the production of tropospheric ozone (O3). Here
Att planera lokal och regional kollektivtrafik i så kallade ’starka stråk’ – det vill säga att koncentrera infrastruktur och resurser till ett antal färre, men attraktivare stråk i en stad eller en region – är ett standardförfarande i samtida kollektivtrafikplanering. Så har inte alltid varit fallet dock. Denna avhandling visar hur organiseringen av beslutsfattande, planeringspraktiker och den rumPlanning local and regional public transport in so-called ’transit corridors’ – i.e., to concentrate infrastructure and resources to few, but more attractive corridors in a city or a region – is commonplace in contemporary public transport planning. This has not always been the case, however. In this thesis I analyze how transit corridors have come to dominate the policies and planning practices o
The discovery of the CRISPR-Cas9 system has revolutionized several areas of biological research by making genome engineering easy, affordable, fast, accessible and scalable. One field that has not yet benefited from this technological advance is that of mitochondrial DNA research. Study I addresses the challenges associated with adapting CRISPR-Cas9 to the mitochondrial environment, and identifies
The 2015 Paris Agreement of the United Nations Framework Convention on Climate Change aims to keep global average temperature increases well below 2 °C of preindustrial levels in the Year 2100. Vital to its success is achieving a decrease in the abundance of atmospheric methane (CH4), the second most important anthropogenic greenhouse gas. If this reduction is to be achieved, individual nations mu
This paper presents a novel approach to understanding violence in service encounters through a sociological lens, focusing specifically on micro-interactional violence. Traditionally, research on violence has focused on structural aspects, linking it to the capitalist system or viewing it as symbolic violence (Gordon & Zainuddin, 2020; Varman, 2010). This study, however, shifts the focus to th
Objectives: The randomized controlled trial comparing digital breast tomosynthesis and synthetic 2D mammograms (DBT + SM) versus digital mammography (DM) (the To-Be 1 trial), 2016–2017, did not result in higher cancer detection for DBT + SM. We aimed to determine if negative cases prior to interval and consecutive screen-detected cancers from DBT + SM were due to interpretive error. Methods: Five
divided the data set temporally, assessing the persistence of identified subgroups over different periods. The reassessment of mortality risk used the targeted maximum likelihood estimation (TMLE) method to achieve more robust causal modeling. Results: We analyzed data from 21,005 children. The mortality risk (6 weeks to 3 years of age) was 5.2% (95% CI 4.8%-5.6%) for children born between 2003 an
