Search results

Background: 5-Hydroxytryptamine (5-HT) receptors 1B, 1D and 1F have key roles in migraine pharmacotherapy. Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo release of calcitonin gene-related peptide (CGRP) in human and animal models. The study aimed to examine the localization, genetic expression and

Evolutionary ecology aims to better understand how ecologically important traits respond to environmental heterogeneity. Environments vary both naturally and as a result of human activities, and investigations that simultaneously consider how natural and human-induced environmental variation affect diverse trait types grow increasingly important as human activities drive species endangerment. Here

High resolution observations with ALMA have revealed that concentric rings and gaps are common features in protoplanetary disks. The favored mechanism for creating these substructures are planet-disk interactions, in which growing planets open gaps in the disk, and particles become trapped at the pressure maxima that form at the corresponding gap edges. Since the particle density in these pressure

Purpose: To describe the rationale and design of the VOYAGER (NCT05476926) study, which aims to investigate the safety and effectiveness of faricimab and the Port Delivery System with ranibizumab (PDS) for neovascular age-related macular degeneration (nAMD) or diabetic macular edema (DME) in clinical practice. VOYAGER also aims to understand drivers of clinical practice treatment outcomes by gaini

Sugar beet molasses is a low-value byproduct from the sugar industry. It contains significant amounts of sucrose (approx. 50% (w/w)), which can be used for many different applications, for example, as feedstock for the production of fuel (as ethanol) and biobased chemicals such as 5-hydoxymethyl furfural (HMF). To produce platform chemicals, sucrose is hydrolyzed into its monomeric C6 sugars: gluc

The toxicity of particulate matter (PM) is dependent on particle physical and chemical properties and is commonly studied using in vivo and in vitro approaches. PM to be used for in vivo and in vitro studies is often collected on filters and then extracted from the filter surface using a solvent. During extraction and further PM sample handling, particle properties change, but this is often neglec

Background: Cardiovascular disease (CVD) is a major global health issue, primarily caused by atherosclerosis. Psychological factors may play a role in the development and progression of CVD. However, the relationship between psychological factors and atherosclerosis is complex and poorly understood. This study, therefore, aimed to examine the association of psychological factors with (i) coronary

Bioenergy plays a major role in the renewable energy supply and is projected to be an important part of the path towards a decarbonised society. Over the past decade, increasing attention has been given to agricultural bioenergy to act as a multifunctional climate mitigation strategy. Energy crops may mitigate climate change while simultaneously contributing to reducing the negative environmental

The effect of plant species diversity on productivity and competitive ability was studied in an experiment carried out simultaneously in five European countries: Czech Republic (CZ), the Netherlands (NL), Sweden (SE), Spain (SP), and United Kingdom (UK). The aim was to separate the 'chance' or 'sampling effect' (increasing the number of sown species increases the probability that a species able 't

1 Plant species differ in their capacity to influence soil organic matter, soil nutrient availability and the composition of soil microbial communities. Their influences on soil properties result in net positive or negative feedback effects, which influence plant performance and plant community composition. 2 For two grassland systems, one on a sandy soil in the Netherlands and one on a chalk soi

Abstract in UndeterminedThis study deals with a current problem of urban human-biometeorology on the micro-scale, which becomes more important due to the future increase of severe summer heat in Central Europe. The impact of street design parameters on the thermal comfort of citizens is analysed in an experimental way for typical summer conditions in Central Europe. The investigation is focused on

Around 70,000 osteoporosis-related fractures occur in Sweden annually and approximately half of the women in western world will sustain a fragility fracture after the age of 50 years. Fracture preventive efforts require the identification of individuals who are at high risk. Biochemical markers of bone turnover (BTMs) have shown some degree of fracture predictability. There is also a correlation b

Ovarian cancer is the seventh most common cancer in women globally, with approximately 240,000 new cases annually. Although a rare disease, it is the most lethal gynecologic malignancy. Unspecific symptoms result in late diagnosis and a generally poor prognosis. However, ovarian cancer is a heterogeneous disease comprising different disease entities, which is of importance in clinical decision-mak

Understanding the mechanisms of complex polygenic diseases like type 2 diabetes (T2D) is as complex as their nature. Cellular processes involved in glucose homeostasis need high and reliable energy supply. Mitochondria are the major energy producers in mammalian cells. Since majority of the mitochondrial genes are encoded by the nuclear genome, a tightly regulated and coordinated nuclear-mitochond

Popular Abstract in Swedish Det finns många skäl till varför streptomyceter är en intressant grupp av bakterier att undersöka. Den här avhandlingen fokuserar på celldifferentieringen hos dessa organismer och deras förmåga att bilda en specialiserad typ av tåliga celler som kallas sporer. Genom att studera sporuleringsprocessen hos dessa bakterier kan man lära sig mycket om fundamentala livsprocessStreptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division i

Popular Abstract in Swedish De generella företeelser som sker i samband med en axonal skada i det perifera nervsystemet (PNS) har tidigare beskrivits i detalj. Däremot är de molekylära mekanismer som ligger bakom celldöd, eller bakom nervcellens förmåga att regenerera efter en axonal skada, ringa studerade. Den här avhandlingen behandlar en sådan molekylär mekanism, JNK-medierad aktivering av c-JuThe events associated with axonal injury in the peripheral nervous system (PNS) have been described in detail. However, the molecular mechanisms underlying the regenerative response, or neuronal cell death, following axonal injury are poorly understood. This thesis concerns one such molecular mechanism, JNK-mediated c-Jun activation, in peripheral sensory and sympathetic neurons. By immunohistoche

Popular Abstract in Swedish Benskörhet (osteoporos) är en sjukdom som karaktäriseras av minskad mängd benmassa och försämrad benkvalitet. Benskörhet leder till en ökad risk för frakturer. Förekomsten av benskörhet har fördubblats under de senaste decennierna. Upp till en tiondel av alla män och en fjärdedel av alla kvinnor lider av sjukdomen. Ökningen av benskörhet i samhället kan delvis förklaras

Studies of the long-lived anthropogenic radionuclides 99Tc, 237Np, 239Pu and 240Pu were performed in marine and terrestrial areas contaminated by different accidental and controlled releases of radioactive materials. The three main sources discussed in this thesis are nuclear weapons tests, nuclear reprocessing plants and the Chernobyl accident. Results are mainly based on measurements of environm