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Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. The thesis evaluates the effect of radiolabelling chemistry on biodistribution and targeting properties of Affibod
Complete resection is the treatment of choice for most pediatric brain tumors, but early postoperative MRI for detection of residual tumor may be misleading because of MRI signal changes caused by the operation. PET imaging with amino acid tracers in adults increases the diagnostic accuracy for brain tumors, but the literature in pediatric neurooncology is limited. A hybrid PET/MRI system is highl
Background: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 and 18 months after treatment initiation. Methods: ORBIT (online remote behavioural intervention for tics) was a two-arm (1:1 ratio), superiority, sing
Estimates of land-atmosphere exchanges of carbon, energy, water vapor, and other greenhouse gases based on the eddy covariance (EC) technique rely on the fundamental assumption that the flux footprint area is homogeneous. We investigated the impact of source area heterogeneity on flux estimates in single-level EC measurements over a managed boreal forest landscape. For this purpose, we compared si
Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discover
The release of anthropogenic greenhouse gases (GHGs) has substantially increased the global mean surface air temperature. Increases in global mean surface air temperature will lead to warmer and drier conditions, promoting more frequent, long-lasting, intense forest wildfires. The usage of remote sensing (RS) can aid in quantifying forest characteristics and large-scale changes in forest ecosystem
Segregation är ett vanligt fenomen som uppstår över hela världen. De negativa konsekvenserna av boendesegregation har visat sig vara många för de som bor i mindre välbärgade stadsdelar. Bland konsekvenserna finns bland annat hälsorelaterade motgångar, men även sämre förutsättningar under skolgången och i det framtida arbetslivet har konstaterats. Sydafrika lämpar sig väl för att studera segregatioSegregation is a common phenomenon arising worldwide. Residential segregation has been shown to have several negative consequences for people living in less wealthy neighbourhoods, such as health-related setbacks and being less likely to cope with school. South Africa is an especially well-suited country to study segregation and methods to counteract it to achieve better integration and more harmo
I denna rapport undersöks hur olika åtgärder påverkar trafiksituationen för oskyddade trafikanter i korsningar. Undersökningen görs främst utifrån de tre aspekterna trafiksäkerhet, framkomlighet och omgivande miljö. Arbetet omfattar sex korsningar i Helsingborg som har byggts om vid olika tidpunkter och där olika åtgärder har vidtagits. För att göra en bedömning av åtgärdernas påverkan på trafiksäThis report examines how different traffic improvement measures affect the traffic situation for vulnerable road users at intersections. The survey is conducted mainly based on the three categories of road safety, accessibility and the surroundings. The work investigates six intersections in Helsingborg that have been rebuilt at different times and where different measures have been taken. To eval
This work aimed to characterize single chain fragment variables (scFvs) against S100A7 and Calprotectin, proteins part of the Ca2+ binding S100 family that have been associated with inflammatory diseases and cancer. The mechanisms governing the physiological functions of S100 proteins are not fully understood, but it is known that many of them contribute to maintaining homeostasis in the intracell
Freshwater systems are active components of the global carbon cycle and contribute to global CO2 emissions. Freshwater studies in the Arctic are underrepresented, especially regarding lakes and their Dissolved Organic Carbon (DOC) reactivity and composition dynamics. DOC is a main part of DOM (dissolved organic matter), which drives processes central to carbon cycling, influences chemical and biol
Non-fungible tokens (NFTs) are a type of cryptocurrency that consist of unique, non-exchangeable tokens, which are traded on a blockchain. These unique tokens are associated with digital assets such as images, art, videos, or music. With the rapid rise of NFTs’ popularity in 2021, a community established around trading, selling, and collecting of NFTs. This study explored the NFT community at larg
This thesis investigates the importance of scale for power dynamics in the negotiation of risks connect-ed to Urban Rivers in Nairobi, Kenya. In addition to unequal distribution of wealth, global inequalities in the distribution of risk become increasingly important. Scale as a significant dimension of inequality is discussed in the context of Nairobi’s urban, as water scarcity and flooding events
With the development of low energy buildings in Northern European countries, conflicts regarding balancing daylight and energy performances in buildings arise. Therefore, design solutions that balance daylight and energy performances in buildings are needed. MKB Greenhouse is a newly-built, Miljöbyggnad Gold and Feby-Passive House certified, multi-family housing in Malmö, Sweden. Greenhouse also e
The energy demand of the world continues to increase, while world's resources are exploited over its capacity. One way of facing these demands is to extend the use of fuel cells. A fuel cell converts chemical energy into electrical energy through a series of chemical and electrochemical reactions. A solid oxide fuel cell (SOFC) is unique since it only contains solid materials and the cell has
Thesis Purpose: The purpose of this thesis is to provide an understanding of how brands relaying moral messages in their communication are perceived by consumers. Therefore, it investigates consumers’ brand meaning resulting from exposure to brands’ moral messages on social media. This thesis thereby enhances knowledge regarding the consumer perspective of moral branding and furthermore contribute
The world today stands at a cross roads when it comes to energy and electrical grids. A large part of the worlds population still lacks access to reliable working electricity 24 hours a day. Much of this is in remote and poor parts of the world. For much of the 20th century large centralized AC grids have been the norm to provide people with electricity. But for remote parts of the world including
With millions of yearly beach visitors in southern California, beach water quality represents an important factor in public health and ocean dependent economy. Fecal indicator bacteria (FIB) in water is much easier to measure than disease causing organisms but correlation exists between the two. For this reason, FIB concentrations are used to measure recreational water quality and related health r
Galectins are an old fifteen-member protein family. Every galectin has one or two highly conserved carbohydrate recognition domains (CRDs) through which it binds their mutual ligand galactose. They are involved in various pathways such as signaling, autophagy and immune response. However, they also contribute to pathological functions including fibrosis, metastasis, cardiovascular diseases and dia
