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The PResymptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) is an investigator-driven study that was created in 2011 and enrolled cognitively normal older adults with a family history of sporadic AD. Participants are deeply phenotyped and have now been followed annually for more than 12 years (median follow-up 8.0 years, SD 3.1). Multimodal magnetic reson

Background: The benefit of surgical resection for colorectal cancer (CRC) lung metastases is unclear. The aim was to investigate the incidence, treatment strategy, and 5-year overall survival (OS) in CRC patients with isolated lung metastases. Methods: This registry-based retrospective cohort study included patients treated with curative resection of CRC within the county of Skåne during the perio

Uppsatsen behandlar hur miljörelaterade fordringar hanteras när en verksamhet går i konkurs och i vilken utsträckning principen om att förorenaren ska betala får genomslag i svensk konkursrätt. Utgångspunkten är de praktiska problem som uppstår när kostsamma efterbehandlingsåtgärder aktualiseras först efter konkursutbrottet, samtidigt som det inte finns någon generell skyldighet för staten eller kThis thesis examines how environmental claims are treated when a business is declared bankrupt, and to what extent the polluter pays principle is upheld in Swedish bankruptcy law. The point of departure is the practical difficulties that occur when costly remediation measures become relevant only after the opening of bankruptcy proceedings, while there is no general legal obligation for the State

BACKGROUND: – Proteins linked to heritable coronary heart disease (CHD) could uncover new pathophysiological mechanisms of atherosclerosis. We report on the protein profile associated with a family history of early-onset CHD and whether the relation between proteins and coronary atherosclerotic burden differs according to family history status, as well as inferences from Mendelian randomization. M

Background Trauma is the leading cause of quality-related mortality in low- and middle-income countries, with an estimated two million preventable deaths each year. Although trauma quality improvement programmes have been utilised in high-income countries for more than three decades, there is no high-level evidence of their effect on patient outcomes. We aimed to assess whether implementing a cont

Sweden’s grocery distribution is routed through a limited number of upstream hubs and relies on corridors and ferry links. When disruptions affect a hub or a critical link, reallocations propagate fast and travel times increase, with some areas losing coverage temporarily. Decentralising the whole system is costly, so targeted resilience options must be evaluated. The purpose of this thesis is to

Popular Abstract in Swedish Avhandlingen handlar om hur radiovågor tar sig fram i miljöer där saker som hus, väggar och fönster är i vägen. Framför allt ligger fokus på hur signalen från en sändare placerad utomhus kan nå fram till en mobil terminal (t. ex. en mobiltelefon) som befinner sig inomhus. Hur mycket signalen dämpas när den passerar väggen är av stor betydelse när man ska avgöra hur långThis thesis deals with radio wave propagation in environments where the propagation is severely influenced by surrounding objects, mainly walls and other building structures. As an introduction, a brief description is given on propagation terms like loss, delay and dispersion along with system functions relevant for the topic. The focus is then placed on propagation from an outdoor transmitter to

Despite advances in the treatment quality of HIV throughout the world, several countries are still facing numerous obstacles in delivering HIV treatment at a sufficiently high quality, putting patients' lives in jeopardy. The aim of this status article is to give an overview of HIV treatment outcomes in the West African country, Guinea-Bissau, and to assess how newer treatment strategies such as l

Populärvetenskaplig sammanfattning: Naturbetesmarker är en av de miljöer som håller den hösta biologiska mångfalden i Sverige (Ingelög et al., 1993). Idag finns endast 10-12 % naturbetesmarker kvar (Jordbruksverket 2005a) av de 2 miljoner hektar som fanns i Sverige på mitten av 1800-talet (WWF, 2006). Naturbetesmarkerna innehar en speciell flora som är anpassad för kontinuerlig störning och näring

Thesis Purpose: The purpose of this thesis is to provide an understanding of how brands relaying moral messages in their communication are perceived by consumers. Therefore, it investigates consumers’ brand meaning resulting from exposure to brands’ moral messages on social media. This thesis thereby enhances knowledge regarding the consumer perspective of moral branding and furthermore contribute

The world today stands at a cross roads when it comes to energy and electrical grids. A large part of the worlds population still lacks access to reliable working electricity 24 hours a day. Much of this is in remote and poor parts of the world. For much of the 20th century large centralized AC grids have been the norm to provide people with electricity. But for remote parts of the world including

With millions of yearly beach visitors in southern California, beach water quality represents an important factor in public health and ocean dependent economy. Fecal indicator bacteria (FIB) in water is much easier to measure than disease causing organisms but correlation exists between the two. For this reason, FIB concentrations are used to measure recreational water quality and related health r

Sustainable development at the local level is greatly impacted by policymaking. In China’s Jingmai Mountain region, the sustainable development policies are centred mostly around the tea industry, due to the social and environmental dynamics surrounding tea in that region. However, considering the complex interlinkages between the tea industry and local environment and society, the policies concer

Traumatic brain injury (TBI) is a common cause of morbidity and mortality in young individuals. Following TBI, the initial injury caused by the head impact is exacerbated by a complex cascade of secondary injury factors leading to increased tissue loss. TBI is an established risk factor for neurodegenerative disorders including Alzheimer disease (AD). In long-term survivors of TBI, increased aggre

In recent years, low-cost flights to smaller cities in Central and Eastern Europe grew fast. This growth offered tourists new possibilities to explore new, lesser-known destinations at a low price. At the same time, urban tourism is a common strategy for urban regeneration and development in Central and Eastern Europe, and therefore, a significant factor of the economic restructuring of Post-Socia

Populärvetenskaplig sammanfattning av examensarbete utfört vid institutionen för byggvetenskaper vid LTH i samarbete med Sweco Civil AB. Under vissa förhållanden kan sugkrafter uppstå i jord. Fenomenet är sammankopplat med hur mycket vatten det finns i marken, desto mindre vatten desto högre sugkraft och därmed mindre risk för att t.ex. jordslänter rasar. För att undersöka detta fenomen har finiIn this master´s dissertation I investigated if it is possible to increase the total stability for excavations in clay, if suction is taken into account during the calculations. The work has been performed at, and in cooperation with, Sweco Civil AB as well as the Dept. of Construction Sciences at Faculty of Engineering LTH, Lund University. The objective of this master´s dissertation is to asse