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PURPOSE. To study the possible involvement of the rod (SLC24A1) and cone (SLC24A2) Na-Ca+K exchanger (NCKX) genes in retinal diseases. METHODS. DNA was collected from unrelated patients with retinal disease, mainly from North America. A human genomic library was screened with the cone NCKX cDNA, and hybridizing clones were sequenced to determine the genomic organization of the SLC24A2 gene. The si
Background: Insulin is a therapeutic protein that is widely used for the treatment of diabetes. Its biological function was discovered more than 80 years ago and it has since then been characterized extensively. Crystallization of the insulin molecule has always been a key activity since the protein is often administered by subcutaneous injections of crystalline insulin formulations. Over the year
Deeper winter snow is hypothesized to favor shrub growth and may partly explain the shrub expansion observed in many parts of the arctic during the last decades, potentially triggering biophysical feedbacks including regional warming and permafrost thawing. We experimentally tested the effects of winter snow depth on shrub growth and ecophysiology by measuring stem length and stem hydrogen (δ2H),
Objectives: Chronic pain is common in older adults, yet little is known of its development and the factors that predict its persistence and onset at old age. The aims of this longitudinal cohort study were to examine the prevalence and incidence of chronic pain and to explore possible risk factors for its persistence and onset in a representative sample of older Swedish adults. Method: Data were c
Migration patterns of Nordic Greylag Geese Anser anserwere studied by means of neck-collaring. A total of 4173birds (738 breeders, 1999 goslings and 1436 moulters;most moulters subsequently identified as belonging to aspecified breeding population) was marked throughoutNorway, Sweden, Denmark and Finland during 1984–1994. This report is based on observations made up to 30June 1995. In general, Nor
Background Late blight (caused by Phytophthora infestans) is a devastating potato disease that has been found to occur earlier in the season over the last decades in Fennoscandia. Up until now the reasons for this change have not been investigated. Possible explanations for this change are climate alterations, changes in potato production or changes in pathogen biology, such as increased fitness o
Objective Emotion regulation group therapy (ERGT) has shown promising results in several efficacy trials. However, it has not been evaluated outside a research setting. In order to increase the availability of empirically supported treatments for individuals with borderline personality disorder and deliberate self-harm, an evaluation of ERGT in routine clinical care was conducted with therapists o
The Southern California Borderland is a region that experiences strong natural variations in bottom water oxygen and pH. We use marine sediments from Santa Monica Basin to reconstruct environmental conditions in the basin's bottom water from the Last Glacial Maximum (LGM) to present. We then compare the records to the adjacent Santa Barbara Basin and Santa Lucia Slope. High-resolution records of b
UNLABELLED: Here we show that a common polymorphism causing a valine to methionine amino acid substitution at codon 418 (V418M) in the CLCN7 gene is associated with femoral neck BMD in women. Our study adds to accumulating evidence that shows that common allelic variants in monogenic bone disease genes often contribute to BMD regulation in normal subjects.INTRODUCTION: The CLCN7 gene is a strong c
Background and ObjectivesIntestinal levodopa/carbidopa gel infusion (LCIG) is superior to oral treatment in advanced Parkinson disease. The primary objective of this trial was to investigate whether continuous subcutaneous or intravenous infusion with a continuously buffered acidic levodopa/carbidopa solution yields steady-state plasma concentrations of levodopa that are equivalent in magnitude, a
Taking advantage of Estonia's small size and population, we have employed wastewater-based epidemiology approach to monitor the spread of SARS-CoV-2, releasing weekly nation-wide updates. In this study we report results obtained between August 2020 and December 2021. Weekly 24 h composite samples were collected from wastewater treatment plants of larger towns already covered 65% of the total popul
Ett förändrat nederbördsklimat i kombination med ökade trafikbelastningar ställer nya krav på vägkonstruktioners utformning och funktion. Syftet med denna litteraturstudie är att undersöka hur vägkonstruktioner påverkas av kraftig nederbörd och tung belastning, samt att analysera skillnader mellan moderna och äldre konstruktioner avseende lastupptagning och vattenhantering. Vidare behandlas hur daA changing precipitation pattern, characterized by shorter but more intense rainfall events, combined with increasing traffic loads, places new demands on road construction design and performance. The aim of this literature study is to investigate how road structures are affected by heavy rainfall and increased loading, as well as to analyse differences between modern and older road constructions
Bygg- och anläggningsprojekt genererar stora mängder schaktmassor, den årliga mängden som uppstår är cirka 60–200 miljoner ton (Naturvårdsverket, 2024). Schaktmassorna behöver hanteras och omhändertas vilket kan innebära att de återanvänds på den plats de uppstått eller att de transporteras bort för att hanteras på annan plats. Däremot kan massorna vara förorenade vilket ställer till problem, exem
Karst caves are known to buffer external climatic variability and track annual temperature and humidity means, yet little is understood about how this buffering extends beyond cave interiors or whether it influences vegetation patterns at cave entrances. This pilot study investigates microclimate (temperature, relative humidity and derived vapour pressure deficit) and vegetation patterns (Shannon
Laccases are multicopper oxidases capable of oxidizing a broad range of phenolic and non-phenolic compounds, making them attractive biocatalysts for lignin valorization and environmental applications. In this work, two bacterial laccases, LacA from Bacillus amyloliquefaciens and MEK from Psychrobacter sp., were recombinantly produced in Escherichia coli BL21 (DE3), purified, and characterized to s
