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Design and synthesis of sialic acid derivatives

Antibiotika är en av de viktigaste upptäckterna under 1900-talet. Med antibiotika blev det möjligt att bekämpa och förhindra bakteriella infektioner. Ett växande och svårlöst problem är antibiotikaresistans. Detta projekt syftar till att hitta alternativ till klassisk antibiotika. Vi har arbetat med sialinsyra, en kolhydrat som återfinns på cellytan. De flesta bakterier tillverkar inte själva siaThe development and the use of anibiotics since the second half of XX century really affected the approach on treatment and prevention of infectious diseases. Despite a lot of resources and energies has been invested on the research, antibiotics resistance is a growing phenomenon in the last years. Today this problem has become a real public health priority worldwide, not only for the important cl

Koldioxidflöde från mark i sydskånsk lövskog, en jämförelsestudie med avseende på dikeskvalitet

Att dika skogar till förmån för bland annat bättre tillväxt kan påverka och förändra faktorer som marktemperatur och markfuktighet vilka är de viktigaste faktorerna för markrespirationen och flödet av koldioxid till atmosfären. Markrespirationen svarar för huvuddelen av koldioxidflödet till atmosfären från ett markbundet ekosystem. Koldioxid är en viktig växthusgas och små förändringar av flödet kDitching forests in favor of for example better tree growth can affect and change factors such as soil temperature and soil moisture. Those are the most important factors for soil respiration and the flow of carbon dioxide (CO2) into the atmosphere. The soil respiration accounts for the major flux of CO2 to the atmosphere from the terrestrial ecosystem. CO2 is an important greenhouse gas and small

Impact of different atmospheric forcings on surface mass balance estimates in Greenland

Grönlands inlandsis utgör världens näst största färskvattensreservoar. Forskning har visat att Grönlands inlandsis förlorar mer och mer massa, vilket också bidrar till den stigande havsnivån, i kombination med andra faktorer. Avrinningen förväntas också öka i framtiden på grund av den globala uppvärmningen. Hur mycket massa som lämnar Grönlands inlandsis beror på den totala massbalansen. Den totalThe Greenland Ice sheet (GIS) is the second largest ice sheet on Earth and thus stores a large amount of Earths freshwater. Because of climate change and the Arctic amplification, GIS is experiencing changes and increased melt rates. The total mass budget determines the amount of sea level rise caused by input from freshwater from the GIS. Surface mass balance (SMB) plus the dynamic mass losses fr

Glacial history of the upper Drac Blanc catchment (French Alps)

Glacier advances in the Écrins massif (French Alps) during the Late Glacial and the Early Holocene are poorly constrained. Based on field observations, a high-resolution digital elevation model and an orthophoto, glacial landforms in the upper Drac Blanc catchment were mapped. Thanks to 42 new 10Be exposure ages, the timing of the stabilisation of selected moraines was constrained. The application

A Room of One's Own Delivery - A Study of Rural Identity in Sweden, and the Emancipatory Potential of Vulnerability in Resistance

Denna studie undersöker den politiska och allmänna diskurs som konstruerar identiteten landsbygdsbo i Sverige, samt vilka konsekvenser denna diskurs har gällande förväntningar på, och förväntningar hos boende i rurala regioner i Sverige. Studien fokuserar på stängningen av Sollefteå BB i Sollefteå sjukhus, Västernorrlands landsting (numera region), i januari 2017 och den ockupation av sjukhuset soThis study examines the political and popular discourse that constructs the identity of the rural citizen in Sweden, and what consequences this discourse has on expectations on, and expectations of rural citizens in Sweden. The study focuses on the closing of the birthing clinic in Sollefteå hospital, Västernorrland county, in January 2017 and the occupation of the ward that followed thereafter. E

A study of photovoltaics and of combining solar power with an existing wind power plant

In this paper, the viability of integrating solar power with an already running wind power plant is examined. The study, conducted in cooperation with Eolus, takes place in Anneberg, Sweden, home to three wind turbines with a combined capacity of 10.8 MW. This study examines whether or not it would be profitable to integrate an additional intermittent power source to the wind power plant’s existin

Germling success in Bladderwrack (Fucus vesiculosus) depending on substrate type & slope

Recruitment of new individuals is essential for a population to survive and flourish and bladderwrack (Fucus vesiculosus) is on the decline in some parts of the Baltic Sea. The causes being multitude and complex, culminating to the loss of light penetration being the main culprit. As society moves forward, artificial submerged structures may serve as new footholds for a waning population as well a

Seasonal distribution of sperm whales in the High Arctic revealed by multi-year passive acoustic monitoring

The sperm whale (Physeter macrocephalus) is a cosmopolitan species with a broad distribution that ranges from the tropics to the poles. Males are known to migrate between nutrient-rich high latitude waters and low latitude breeding grounds. In the North Atlantic, large males are found up to the southern limits of the ice edge. However, their seasonal distribution patterns remain poorly known in th

Automation of High-accuracy Marking Tasks at MAX IV using the Quadrupedal Robot Spot

When installing new research equipment at the synchrotron research laboratory MAX IV, a final positional accuracy of tens of microns is usually needed. To obtain that accuracy, initial reference points must be placed within 2 mm from the nominal target points in CAD, in a process referred to as bluelining. It is currently a manual process where points from a virtual environment are transferred to

Cultivating Community - Exploring an urban design proposal merging food production with future development for sustainable living.

With the global population projected to reach eight billion by 2022, the world faces significant challenges associated with rapid urbanization. The migration of individuals from rural to urban areas in search of improved opportunities exacerbates the strain on resources, posing obstacles such as housing shortages, infrastructure demands, and food scarcity in growing cities. This thesis aims to add

Bothness Despite Otherness: A Synergistic Approach in a North-South Social Enterprise fusing Mutual Collaboration with Degrowth Values

Title: Bothness Despite Otherness: A Synergistic Approach in a NorthSouth Social Enterprise fusing Mutual Collaboration with Degrowth Values Authors: Ricarda Becker and Ladina Kaupp Supervisor: John Murray, Lund University, Sweden Purpose: This thesis aims to identify how mutual collaboration practices are infused with degrowth values within a business context that spans the Global North and the

Consumers' behaviour in the use of online services and the cultures effect on it-a study of Swedes and Danes use of online job databases

The thesis deals with consumers behaviour in the use of online services and the cultures effect on it. It is a study of Swedes and Danes use of online job data bases. The thesis is based on a quantitative study. A questionnaire were used sent out to 80 Swedes and 80 Danes. The theory concerns areas of online consumer behaviour, decision making and services theory as well as theories within culture

Co-evolution of genomes and plasmids within Chlamydia trachomatis and the emergence in Sweden of a new variant strain

Background: Chlamydia trachomatis is the most common cause of sexually transmitted infections globally and the leading cause of preventable blindness in the developing world. There are two biovariants of C trachomatis: 'trachoma', causing ocular and genital tract infections, and the invasive 'lymphogranuloma venereum' strains. Recently, a new variant of the genital tract C trachomatis emerged in S

Male gender is an adverse risk factor only in young patients with diffuse large B-cell lymphoma - a Swedish population-based study

Background. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. Five clinical adverse risk factors are merged into the International Prognostic Index (IPI), which is the major tool for prognostication. In contrast to Hodgkin's lymphoma, gender is not considered as an adverse risk factor for DLBCL patients. As we clinically had observed a very good survival rate in y

No evidence for assortative mating within a willow warbler migratory divide

Introduction: In contact zones, genetic mixing of two taxa can be restricted by prezygotic (e.g. assortative mating) or postzygotic (lower fitness of hybrid offspring) barriers, or a combination of the two. A hybrid zone between two willow warbler subspecies (Phylloscopus trochilus trochilus, P. t. acredula) with distinctive migratory strategies occurs in central Sweden. These subspecies exhibit d

Pseudovirions in the Study of Papilloma- and Polyomaviruses

The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present infections to elucidate natural history and association of infection with subsequent disease. As there are

Composition and microarchitecture of human trabecular bone change with age and differ between anatomical locations

The microarchitecture of trabecular bone adapts to its mechanical loading environment according to Wolff's law and alters with age. Trabecular bone is a metabolically active tissue, thus, its molecular composition and microarchitecture may vary between anatomical locations as a result of the local mechanical loading environment. No comprehensive comparison of composition and microarchitecture of t

Alpha B-crystallin - a validated prognostic factor for poor prognosis in squamous cell carcinoma of the oral cavityl

Conclusion: Alpha B-crystallin was found to be an independent prognostic marker for poor prognosis in oral cavity tumours. For oropharyngeal cancer, alpha B-crystallin had no prognostic value. Objective: The aim of this study was to see if earlier findings of alpha B-crystallin as an independent prognostic marker, and SPARC/osteonectin, PAI-1 and uPA as a prognostic combination for poor outcome in

Reaction Mechanism of Manganese Superoxide Dismutase Studied by Combined Quantum and Molecular Mechanical Calculations and Multiconfigurational Methods.

Manganese superoxide dismutases (MnSODs) are enzymes that convert two molecules of the poisonous superoxide radical into molecular oxygen and hydrogen peroxide. During the reaction, the manganese ion cycles between the Mn(2+) and Mn(3+) oxidation states and accomplishes its enzymatic action in two half-cycles (corresponding to the oxidation and reduction of O(2)(*-)). Despite many experimental and