Filetype
The kinin system is activated when high-molecular-weight kininogen (HK) is cleaved by plasma kallikrein thus generating bradykinin. Bradykinin is a potent proinflammatory peptide that induces plasma leakage, blood pressure drop, liberation of inflammatory cytokines and pain. Vasculitis is an autoimmune systemic inflammatory disease, characterized by leukocyte inflammation in and around vessel wall
This paper introduces a research project with the aim to develop concepts and tools for architectural design, taking the ideas of "behaviour settings" as a starting point, to enable a more relevant holistic view in object oriented design of buildings. In this paper we introduce the concept of "architectural object" as a representation of a real "situation" involving people, behaviour, experience a
Popular Abstract in Swedish De flesta människor bibehåller en relativt konstant kroppsvikt genom livet trots att mängden mat och motion varierar från dag till dag. En konstant kroppsvikt betyder att energiintag (mat och dryck) och energiutgifter (värme och rörelse) i genomsnitt är lika stora, d.v.s. kroppens energibalans är i jämvikt. Övervikt är ett resultat av positiv energibalans, vilket innebä
Popular Abstract in Swedish I det moderna samhället är vi helt beroende av polymera material, från barndomen med blöjor och nappflaskor till ålderdomen med artificiella ögonlinser och höftleder. Dagens sjukvård skulle inte klara de höga hygieniska kraven om inte engångsartiklar såsom gummihandskar, påsar för blodtransfusion och katetrar fanns. I många applikationer är polymerernas ytegenskaperna m
Popular Abstract in Swedish Denna avhandling visar att jordgubbar innehåller ett allergen, proteinet Fra a 1, som är mycket likt det allergen som orsakar besvär vid björkpollen-allergi. Den som får allergiska besvär av jordgubbar, t.ex. att det kliar och blir irriterat i munhålan och svalget när man äter , har ofta en björkpollen-allergi sen tidigare. Motsvarande allergen finns också i en del andrStrawberry (Fragaria ananassa) is an economically important crop, and recognised as an important source of antioxidants and bioactive compounds with health promoting effects. Yet increased incidence of allergy puts a limit to the choice of food for an increasing percentage of the population. As part of this thesis a strawberry allergen termed Fra a 1 was identified, which is related to a major bi
On their route to tropical Africa, European trans-Saharan migrants must cross two major geographical barriers, the Mediterranean Sea and the Sahara Desert, which necessitates the accumulation of large fuel loads. While northern Africa is the chief region where most migrants gain fuel for the Sahara crossing, Iberia is a target area to gain fuel before the sea crossing existing between Europe and A
Background. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas. Five clinical adverse risk factors are merged into the International Prognostic Index (IPI), which is the major tool for prognostication. In contrast to Hodgkin's lymphoma, gender is not considered as an adverse risk factor for DLBCL patients. As we clinically had observed a very good survival rate in y
P>Aims Type 1 diabetes mellitus (T1DM) is an autoimmune disease with potential mechanistic links to immune-related cancers. We aimed at examining the overall and specific cancer risks among hospitalized T1DM patients from the national registers in Sweden. Methods A T1DM research cohort was created by identifying T1DM patients from the Hospital Discharge Register and linking them with the Cancer Re
Background: Alzheimer's disease (AD) is associated with deposition of amyloid beta (A beta) in the brain, which is reflected by low concentration of the A beta 1-42 peptide in the cerebrospinal fluid (CSF). There are at least 15 additional A beta peptides in human CSF and their relative abundance pattern is thought to reflect the production and degradation of A beta. Here, we test the hypothesis t
Mouse apolipoprotein M (m-apoM) displays a 79% sequence identity to human apolipoprotein M (h-apoM). Both proteins are apolipoproteins associated with high-density lipoproteins, with similar anticipated biological functions. The structure of h-apoM has recently been determined by X-ray crystallography, which revealed that h-apoM displays, as expected, a lipocalin-like fold characterized by an eigh
Endothelial cells are among the main physiological targets of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). In endothelial cells TNF-alpha elicits a broad spectrum of biological effects including differentiation, proliferation and apoptosis. alpha 1-antitrypsin (AAT), an endogenous inhibitor of serine proteases plays a vital role in protecting host tissue from proteolytic
The development of models that provide accurate spatio-temporal predictions of ambient air pollution at small spatial scales is of great importance for the assessment of potential health effects of air pollution. Here we present a spatio-temporal framework that predicts ambient air pollution by combining data from several different monitoring networks and deterministic air pollution model(s) with
Sera from 25 metastatic breast cancer patients and 25 healthy controls were subjected to affinity chromatography using immobilized galectin-1. Serum from the healthy subjects contained on average 1.2 mg per ml (range 0.7-2.2) galectin-1 binding glycoproteins, whereas serum from the breast cancer patients contained on average 2.2 mg/ml (range 0.8-3.9), with a higher average for large primary tumour
Background: Renalase (gene name RNLS), a recently discovered enzyme with monoamine oxidase activity, is implicated in the degradation of catecholamines. Recent studies delineate a possible role of this enzyme in blood pressure (BP) maintenance and cardiac protection and two single nucleotide polymorphisms, RNLS rs2576178 A > G and rs2296545 C > G have been associated with hypertension. The latter
The papilloma- and polyomaviruses are small DNA viruses that infect humans. Some members of these virus families can cause cancer in experimental animals and some are also established as carcinogenic to humans. Detection of specific antibodies to these viruses allows tracking past and present infections to elucidate natural history and association of infection with subsequent disease. As there are
In the study reported here we examined the short-term effects (1-3 years) of slash retention (SR) and the long-term effects (13-15 years) of wood-ash application (A) on fine roots and mycorrhizae in a 40-year-old Norway spruce forest in southwest Sweden. Soil cores were used to obtain estimates of the biomass (g m(-2)) of roots in three diameter classes (< 0.5, 0.5-1 and 1-2 mm), root length densi
Epigenetics may play a role in the pathophysiology of type 2 diabetes (T2D), and increased DNA methylation of the metabolic master regulator peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PPARGC1A) has been reported in muscle and pancreatic islets from T2D patients and in muscle from individuals at risk of T2D. This study aimed to investigate DNA promoter methylation and gen
