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Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

BACKGROUND: After amputation, the sensorimotor cortex reorganizes, and these alterations might influence motor functions of the remaining extremities.OBJECTIVE: The authors examined how amputation of the dominant or nondominant upper or lower extremity alters deftness in the intact limbs.METHODS: The participants were 32 unilateral upper- or lower-extremity amputees and 6 controls. Upper-extremity

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr

This essay examines the personifications of Death in Markus Zusak’s The Book Thief (2005), Christopher Moore’s A Dirty Job (2006) and George Pendle’s Death: A Life (2008). The personifications are analysed in terms of gender, anthropomorphism, (im)mortality, agency in conceptual death and attitude towards their occupation as Death. The personifications are also compared to previous portrayals in r

“Water is life”. During the past decade this phrase has been used repeatedly to emphasize the importance of a number of issues surrounding water services provision including, supply, distribution, governance and political will. This research seeks to investigate the Nairobi City Water and Sewerage Company (NCWSC), a water utility in Kenya, which faces the monumental task of providing water and san

Problemdescription As the environmental awareness grows in society customers becomes more conscious about their emissions from energy consumption. Moreover expectations are that future directives and legislations will force the energy sector to support energy efficiency towards the end user. This master thesis' challenge is to find opportunities for future changes, the key questions to answer

Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

This thesis is about autistic women. It is about how we, as a society, construct and perceive normality and motherhood as a normative ideal for women. It is also about a dis/ability that often goes unnoticed since autism is not defined by any visible markers. Rather, autism is categorized by behaviour considered atypical through the medical gaze. How to make visible the invisible, the in-between

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Lymphocytes from human peripheral blood were separated by Countercurrent distribution (CCD) in a charged aqueous two-phase system composed of Dextran T 500 and polyethylene glycol 6000. Maximal responses to the T-cell mitogens phytohemagglutinin and concanavalin A were detected in a part of the distribution corresponding to the area where the highest percentage of E rosetting cells were seen. Anti

We present an interim archaeological report on the ship- wreck of the Danish-Norwegian flagship Gribshunden. Built in 1485, extensively employed by King Hans as his floating castle, and ultimately lost in June 1495 en route to Kalmar, the ship carried people and material selected to further the political goal of re-unifying the Nordic region. Three field campaigns led by Lund University and Blekin