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Introduction: The timing of prophylaxis and F8 genotype can impact treatment outcomes in adults with severe haemophilia A (HA). Aim: To investigate how F8 genotype, timing, and type of prophylaxis influence arthropathy, bleeding rates, factor consumption and health-related quality of life (HRQoL). Methods: Thirty-eight patients with severe HA were enrolled. Bleeding events were recorded retrospect

The Arctic-Boreal region is projected to experience spatially divergent trends in snow depth following climate change. However, the impact of these spatial trends has remained largely unexplored, despite potentially large consequences for the carbon cycle. To address this knowledge gap, we forced a customised arctic version of the dynamic vegetation model LPJ-GUESS with daily CMIP6 outputs from a

Statistical Jump Models are a class of regime identification models,similar to Hidden Markov Models, with the added advantage of facilitatinglarge-scale integration of exogenous variables that influence thelatent regime-switching process. Recent advancements in SJMs includethe introduction of automatic feature selection techniques, which eliminateirrelevant exogenous information and enhance the mo

An immunoelectron microscopic technique using protein A-gold as a specific marker was used for precise intracellular localization of eosinophil granule proteins. Eosinophils from healthy individuals were isolated in metrizamide gradients. Eosinophil cationic protein (ECP) and eosinophil peroxidase (EPO) were clearly located in the matrix of the large crystalloid-containing granules. In addition, E

Effects of carbon functionalization on the catalytic properties of the space underneath epitaxial graphene flakes on Ir(111) are investigated with Ambient Pressure X-ray Photoelectron Spectroscopy studies of oxygen hydrogenation. The 0.1 mbar oxygen atmosphere hosting O-intercalated graphene flakes was replaced with hydrogen pulses lasting 50 s each, triggering the water formation. Underneath prisChemical reactions confined to near atomic scales have many hypothesized applications. The demand for ever smaller electronical components with superior electric properties for example requires atoms to group in specific shapes that can only be cast in confined spaces. Biological cells are an example of confined reactions in the nature. Hence, in order to recreate those processes, to develop bette

Problem Description Both academic researches and consulting firms claim that Internet of Things will come to change the society we live in, as well as create entirely new business opportunities for companies. However, there is little research that analyzes the actual benefits with Internet of Things, how companies should act in order to find these benefits, and in what way their business models m

3D-modell av höftbenet kan hjälpa till att förutspå artros Det är viktigt att förebygga sjukdomar innan de bryter ut. Vanliga 2D-röntgenbilder är inte alltid tillräckligt noggranna men med 3D-modeller kan tidiga tecken på artros lättare identifieras. Vi strävar för att få fram 3D-bilder av höften från vanliga röntgenbilder.Osteoarthritis and osteoporosis are two medical conditions involving the hip which affect the life quality of many people worldwide. These two diseases are diagnosed with 2D imaging by analysis of radiological measures, bone mineral density and joint space. Computed Tomography (CT) can provide 3D images of the hip, but has higher cost and imposes a higher radiation dose to the patient. Another op

Daily-deal websites have recently been a new and successful way of attracting product service providers since they offer ‘‘free’’ advertising and at the same time the opportunity to sell products and services via certain promotional campaigns. However, research on the concept of daily deal consumer behaviour has been somewhat limited in the context of online shopping, especially regarding empirica

This thesis explores how the European Union implements the concept of open strategic autonomy through three recent trade policy instruments: the International Procurement Instrument, the Foreign Subsidies Regulation, and the Anti-Coercion Instrument. In response to growing geopolitical tensions, supply chain vulnerabilities, and the stagnation of multilateralism, the EU has increasingly turned to

The Arctic has increasingly emerged as a geopolitical horizon shaped by environmental, security and economic transformations. As sea ice melts and military and commercial interests materialise, questions arise about how the region is discursively constructed by various stakeholders. With the Arctic Council in flux, alternative forums have gained significance as sites for dialogue and public diplom

Despite articulations of the Dublin Statement which stress the need to include women in decision-making on water, women are significantly under-represented in transboundary water governance. This thesis examines the Women in Water Diplomacy in the Nile-network by asking how the network constructs a feminist discourse on transboundary water governance in the Nile basin. Rooted in the theoretical fr

Amidst global strategic rivalry and the growing politicization of interdependence and technology, structural influence within transnational economic systems underpinning high-tech industries has become an increasingly important source of strategic leverage. Within this context, this thesis investigates whether the European Union (EU) can derive geoeconomic power from its position in the global sem

In the construction of high-speed railways, an important starting point is to make as little Intrusion on land as possible, therefore it is of high importance to carefully investigate which construction alternatives are the most advantageous. The purpose of this work is to compare and evaluate land use and building on viaduct. The work will be based on literature and interview studies. Sections of

This paper investigates how multilingual speakers may recognize compounds, focusing on the theory that a multilingual recognizes a compound equivalent of a compound faster than a monomorphemic equivalent of a compound. To test this, I administered a translation recognition task to native speakers of Swedish who spoke English as their first L2. The informants were shown the pairs in sequence and ei