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This thesis considers a model of high energy particle collisions. The model is based on the so called BFKL formalism which is valid only at low x, that is collisions at very high energies, such as at the LHC. The intial state of the incoming particles are simulated by colour dipoles in transverse space evolved through rapidity. With this approach, all fluctuations are dynamically described, allowi
Background: Swedish nursing homes (NH) have limited capacity. As a result elderly people living in NH represent the part of the elderly population in most need of care. In Sweden a General Practitioner (GP) is usually responsible for the medical care of all subjects living in a NH. The residents in NH seldom have adequate pharmacological treatment according to diagnosis and often have polypharmacy
Neurotrophic factors are secreted proteins responsible for migration, growth and survival of neurons during development, and for maintenance and plasticity of adult neurons. Here we present a novel secreted protein named Cometin which together with Meteorin defines a new evolutionary conserved protein family. During early mouse development, Cometin is found exclusively in the floor plate and from
The aim of this study was to gain knowledge about the specific needs that a web-based support system for young carers (YCs) must meet. Twelve young people with experience of caring for and supporting a close friend, partner or relative with mental illness (MI) were interviewed about their life situation, support needs and opinions about a hypothetical web-based support system. The transcribed inte
Background: A worse outcome has been reported for cutaneous malignant melanoma (CMM) patients with low socioeconomic status. We have investigated the association between level of education, clinical stage at diagnosis (stage at diagnosis) and CMM-specific survival in Sweden. Methods: We identified 27,235 patients from the Swedish Melanoma Register diagnosed with a primary invasive CMM between 1990
Group B Neisseria meningitidis is a human pathogen, for which a universally effective vaccine is still not available. Immune responses to bacteria are initiated by dendritic cells (DC), which internalize and process bacterial antigens for presentation to T cells. We show here that optimal IL-12 and TNF-alpha production by human monocyte derived DC in response to killed serogroup B N. meningitidis
Factor I (FI) is the major complement inhibitor that degrades Ob and C4b in the presence of cofactors such as factor H (FH) and membrane cofactor protein (MCP). Recently, mutations and polymorphisms in complement regulator molecules FH and MCP but also in FI have been associated with atypical hemolytic uremic syndrome (aHUS). HUS is a disorder characterized by hemolytic anemia, thrombocytopenia an
Objective: Cord blood islet autoantibodies in children born to mothers with type 1 diabetes may be associated with a reduced risk of islet autoimmunity and diabetes. The aim of this study was to investigate in children with type 1 diabetes but born to non-diabetic mothers whether islet autoantibodies at birth affected their presence at diagnosis. Patients and methods: Serum samples at birth and at
A decade ahead of their time, von Schantz et al. united sexual selection and free radical biology by identifying causal links between deep-rooted physiological processes that dictate resistance to toxic waste from oxidative metabolism (reactive oxygen species, ROS), and phenotypic traits, such as ornaments. Ten years later, these ideas have still only been tested with indirect estimates of free ra
Popular Abstract in English The long-term stability of the global terrestrial carbon sink has been a matter of concern in that a weakening would have serious consequences for atmospheric CO2 concentrations and, hence, for further changes in climate. High northern latitudes are of special importance for the global carbon budget as they store large amounts of organic matter in the soil and are expecHigh northern latitudes are of special importance for the global carbon budget as they store large amounts of organic matter in the soil and are expected to be the most strongly affected by climate change. Here we investigate carbon exchange in the subarctic mountain birch forest growing on the limit where tree growth is possible. The study sites are located close to the Abisko village in norther
Although smoking is associated with cardiovascular disease (CVD), many individuals remain healthy after many years of smoking. The population based cohort 'Men born in 1914' was used to investigate whether the occurrence of non-invasively detected atherosclerosis among smokers is associated with lung function [(i.e. height-adjusted forced expiratory volume during 1 s (FEV1.0) and vital capacity (V
Streptococcus dysgalactiae subsp. equisimilis (group G streptococci; GGS) cause disease in humans but are often regarded as commensals in comparison with Streptococcus pyogenes (group A streptococci; GAS). The current study investigated the degree and kinetics of the innate immune response elicited by the two species. This was assessed as expression of the chemokine MIG/CXCL9 and bacterial suscept
Popular Abstract in English Since the first generation of the Toyota Prius was first introduced in December 1997, the number of Hybrid Electric Vehicles (HEVs) and pure Electric Vehicles (EVs) available in the market has increased substantially, and nowadays almost every car manufacturer has at least one HEV or even EV model within their range. The reason behind this trend relies on the increased Since the first generation of the Toyota Prius was introduced in December 1997, the number of Hybrid Electric Vehicles (HEVs) and pure Electric Vehicles (EVs) available in the market has increased substantially. The growing competition existent puts high demands on the electric system as well as the rest of the vehicle. As a consequence, substantial design effort is devoted to optimize both at sys
