Filetype
Background:Expression of the chemokine CXCL14 has previously been shown to be elevated in the tumour stroma of, for example, prostate and breast cancer. Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. However, the prognostic significance of compartment-specific expression of CXCL14 has not been studied.Methods:CXCL14 mRNA expression
Following female sex and age, mammographic density is considered one of the strongest risk factors for breast cancer. Despite the association between mammographic density and breast cancer risk, little is known about the underlying histology and biological basis of breast density. To better understand the mechanisms behind mammographic density we assessed morphology, proliferation and hormone rece
The ability to form long-term memories exists very early during ontogeny; however, the properties of early memory processes, brain structures involved and underlying cellular mechanisms are poorly defined. Here, we examine the role of extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinase/ERK signaling cascade, which is crucial for adult memory, in the consol
Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine
This study determines the technical and economic feasibility of separating dye from a process filtrate in industrial textile recycling using electrocoagulation or sequences of membrane filtration with microfiltration, ultrafiltration, nanofiltration and reverse osmosis. The lower requirements for treating this stream, compared to previously researched dyehouse effluents, left treatments not good e
Neonicotinoids, e.g. clothiandin, imidacloprid and thiamethoxam, is the most used class of insecticides worldwide. However, lately, this group of insecticides has been subject to controversy. Due to the systemic traits of neonicotinoids, the active compound is translocated throughout the whole plant, which provides effective and long-lasting protection against herbivorous pests. On the other hand,
This thesis empirically investigates the question if US firm’s capital structures are stable over longer periods of time and which firm characteristics drive optimal leverage. The analysis is based on a Compustat panel data sample consisting of 2,900 US firms between 1985 and 2016. After analyzing the stability of firm’s capital structure via a “narrow band” and a “relative bucket approach” an err
Bikunin and alpha1-microglobulin are two plasma proteins of about 25 kDa which are made in the liver from a common precursor. The concentration of bikunin in human urine has been shown to increase several fold during various conditions of stress. The mechanism behind this increase is unknown. We have studied pregnant rats and found that the bikunin and alpha1-microglobulin levels in their urine in
Cosmology presents students with ideas that stimulate their curiosity and brings together various concepts from STEM that call on a variety of reasoning types across multiple representational modes, involving subtleties of spacetime relations, a variety of models and evidence requiring multiple lines of high precision observations. This study investigated high school students’ levels and types of
Previous microdialysis experiments have shown that acetylcholine (ACh) release from septal grafts in the hippocampus of awake rats is influenced by the behaviour of the animals, which strongly suggests that the host brain can exert a regulatory control over the activity of the grafted neurons. Since the activity of the normal septo-hippocampal cholinergic system is likely to be regulated, in part,
Plastic’s unique properties are vital for a sustainable future, but its excessive global use signifies consumer society’s wastefulness, often found in short-lived products. Plastic development has overlooked recycling needs, resulting in low material recycling due to a wide array of plastic types with varying additives, leading to recycling challenges. Research focused on thermoplastics aims to re
This thesis investigated the ambitions of Japan in the space sector through the development of the country’s space programme. Drawing on content and discourse analysis of policy, law, strategy documents, the Japan Aerospace Exploration Agency website and documents about the ISS, this thesis explored how Japan has been articulating their space ambitions since 2000. It aimed at analysing the ambitio
Urban wildness refers to natural ecosystems within built-up areas that are subject to minimal human interference. It can provide huge social benefits and contribute to more liveable towns and cities. It can provide places for active recreation, aesthetic enjoyment, and interactions with nature that are otherwise unavailable in urban environments. It can improve health and wellbeing by encouraging
The study of clines, or geographical variations of a given trait, can help understand how the interactions of genetics and local environments determine phenotypic diversity. The marine snail Littorina saxatilis (Olivi, 1792) exhibits a gradual change in the relative frequencies of shell color morphs across populations in the estuary system of the Rias Baixas (Galicia, NW Iberian Peninsula). A cons
In inflammatory bowel disease (IBD) the pathogenetic process is characterized by dysbiosis, increased permeability, translocation, and immune activation. The aim of the present study was to assess the presence of viable bacteria in the blood of patients with IBD and to correlate the findings with clinical characteristics. The study included 28 patients with Crohn’s disease (CD) (median age 38 year
OBJECTIVE: Childhood obesity may impact the risk of islet autoimmunity (IA). The trajectory of BMI through childhood resembles the early peak incidence of first-appearing autoantibodies against insulin (IAA-first) but not GAD65 (GADA-first). We studied whether a child's BMI can impact the age-related risk of first-appearing IA phenotypes.RESEARCH DESIGN AND METHODS: We identified 7,724 children at
Although the nuclear era and the Cold War superpower competition have long since passed, governments are still investing in Big Science, although these large facilities are nowadays mostly geared towards areas of use closer to utility. Investments in Big Science are also motivated not only by promises of scientific breakthroughs but also by expectations (and demands) of measurable impact, and with
