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The present study aimed to study the relation between the release of arachidonic acid (AA) and the energy state in cerebral cortices of rats during single episodes of cortical spreading depression (CSD). The changes in concentrations of AA, labile phosphate compounds [ATP, ADP, AMP, and phosphocreatine (PCr)], and glycolytic metabolites (lactate, pyruvate, glucose, and glycogen) were studied durin
The official iMechanica Blog for the Elsevier Journal Engineering Fracture Mechanics
Mitochondrial uptake of calcium in excitotoxicity is associated with subsequent increase in reactive oxygen species (ROS) generation and delayed cellular calcium deregulation in ischemic and neurodegenerative insults. The mechanisms linking mitochondrial calcium uptake and ROS production remain unknown but activation of the mitochondrial permeability transition (mPT) may be one such mechanism. In
Jak tyrosine kinases have a unique domain structure containing a kinase domain (JH1) adjacent to a catalytically inactive pseudokinase domain (JH2). JH2 is crucial for inhibition of basal Jak activity, but the mechanism of this regulation has remained elusive. We show that JH2 negatively regulated Jak2 in bacterial cells, indicating that regulation is an intrinsic property of Jak2. JH2 suppressed
Background/Aims: Motor impairment is an important aspect of cognitive decline in older adults. It has been suggested that complex motor control is affected earlier than gross motor control. The aims were to investigate if complex hand motor function was more affected than gross motor function in cognitively impaired older subjects, and to present reference values. Methods: Alternating forearm move
The pathophysiology behind gastrointestinal dysmotility in diabetes mellitus is unknown. Both esophageal dysmotility and gastroparesis have been shown to be associated with retinopathy, suggesting that microangiopathy is important in the common etiology. The aim of the present study was to examine whether patients with diabetes exhibit microangiopathy in the colon, and if present, to correlate mic
According to direct perception theory (DPT) people understand each other’s minds by way of perceiving each other’s behavioral engagements in the world. I argue that DPT admits of two interpretations. One interpretation is found in Searle’s social ontology. The other interpretation departs from an enactivist account of social cognition. Both can be employed to make sense of what it is to perceive o
Consumers’ ethical efforts are capped by unethical market forces. A longitudinal study of anti-consumers shows that when systemic support was removed, consumers previously fully committed to ethical lifestyles, exhibited symptoms of an ethical consumption gap, suggesting the problem lies not with the individual (gap) but with the context (cap).
Conclusion: Education, but not occupation, was differentially associated with adult asthma phenotypes in the general population. Further research into socioeconomic status variation in various asthma phenotypes is warranted.
Popular Abstract in Undetermined Nanoparticles have attracted great interest in biomedicine and material science due to their unique and unconventional properties. Polymer nanoparticles containing pre-designed molecular recognition sites can be synthesized using molecular imprinting technique. Molecularly imprinted polymers (MIPs) have high affinity and selectivity that are similar to antibodies,Molecularly imprinted polymers (MIPs) have attracted great interest in many applications including bioseparation, chemical sensing, catalysis, drug delivery, etc. Recently, molecularly imprinted nanoparticles have become accessible due to a number of synthetic methods that have been developed. The high molecular binding selectivity, fast binding kinetics and colloidal stability make MIP nanopartic
The EU, being the largest trading partner for many developing countries, offers a General Scheme of Preferences (GSP) as a voluntary trade promoting scheme. Through GSP+, an extension of GSP, the EU offers additional market access conditional on commitment to sustainable development and good governance. Using a Gravity Equation, I find insignificant trade creating effects on GSP+ in comparison wit
Denna uppsats är ett kulturanalytiskt forskningsprojekt som syftar till att förstå hur sociala och kulturella processer i olika rum i staden bidrar till upplevelsen av ofrivillig ensamhet. Uppsatsen undersöker den ofrivilliga ensamheten i olika skalor i staden, från bostaden, kvarteret, ut i bostadsområdet och vidare ut i staden. Detta uppnås genom att använda ett fenomenologiskt ramverk som analyThis thesis is a cultural analytical research project that aims to understand how social and cultural processes in spaces within the city contribute to the experience of loneliness. The thesis explores loneliness at different layers of the city, from housing, the neighbourhood, to the district and the wider city scale. This is achieved by using a phenomenological framework that analyses the indivi
Senior lecturer Contact details Email: paul [dot] pierce [at] ics [dot] lu [dot] seOrganisation Department of Informatics Room number: EC2-225 Service point: 10 WebpagePaul Pierces profile in Lund University research portal Publications Displaying of publications. Sorted by year, then title. Filter by type AllArticleBook chapterDoctoral Thesis (monograph)Paper in conference proceedingPaper, not in
https://www.lusem.lu.se/paul-pierce - 2026-07-16
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IntroductionUmbilical cord blood measurement is the gold standard of evaluating neonatal metabolic status at birth. Dual sampling of cord blood vessels is clinical routine, yet the long-term value of venoarterial differences (ΔpH) is undetermined. The objective was to investigate the association of ΔpH, to long-term mortality and morbidity up to 20 years.Material and methodsThis was a retrospectiv
