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The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the leucine-rich repeat kinase 2 (LRRK2) gene was identified, with p.R1398H appearing to be the most likely functional variant. To date, the consistency of the protective effect of LRR
NYTT FRÅN LUNDS UNIVERSITET Mejlutskick på svenska och engelska som vänder sig till fakultetskommunikatörer vid Lunds universitet för vidarespridning i fakultets- och institutionskanaler – Nr 13 v 15 - 2021. UNIVERSITETSGEMENSAMT Nationell enkät om sexuella trakasserier Det pågår en nationell forskningsstudie om sexuella trakasserier i akademin. Studien är ett samverkansprojekt mellan Karolinska i
https://www.cec.lu.se/sites/cec.lu.se/files/2021-04/LU-gemensamt%20Mejlutskick%20Nr%2013-v15-2021.pdf - 2026-07-10
Spontanopera LUNDS UNIVERSITETS MAGASIN | NR 6 | 2017 FÖRSTA DOKTORN UT I IMPROVISERAD SÅNG Så hanterar du skitstövlar på jobbet Nytt centrum satsar på forskarpar Livet efter utmattningen 2 LUM NR 6 | 2017 LUM NR 6 | 2017 3 Lunds universitets första gemen- samma hemvändarhelg någonsin hölls i oktober i 350-årsjubileets glans. Tvåhundra alumner åter- vände för att välja och vraka ur ett späckat pro
https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-6-2017.pdf - 2026-07-10
Local democracy is theoretically based on political parties offering different policies across and within sub-national geographical units. However, local democracy is embedded within a multilevel party and institutional structure that may compromise this endeavour. This study develops three expectations of policy variation: within party variation in political positions across geographical units; d
Deficiency in C1 inhibitor (C1INH, SERPING1) is canonically associated with hereditary angioedema (HAE-C1INH) but not thrombosis. To determine the thrombosis risk conferred by loss of C1INH in the general population, we studied genetically-defined C1INH deficiency across 635,823 participants. Functionally deleterious germline coding variation in SERPING1 was rare (~1:10,000), indicating strong gen
This article provides a critical view of Judgment No. 238 of 2014 handed down by the Italian Constitutional Court. By and large the comments presented below pertain to the single issue of the relationship between different legal orders - between the legal orders of two states, or between the legal order of one state and the legal order of international law. The following comments are based on a po
Thyroid hormone (TH) signaling plays a major role in the development, energy homeostasis, and metabolism of most tissues. Recent studies have identified THs as drivers of prostate cancer (PCa) development and progression. We reported that the T3-scavenger protein µ-crystallin (CRYM) regulates the development and progression of PCa and that this involved crosstalk with androgen receptor (AR) signal
Herein, we contextualize, problematize, and offer some insights for moving beyond the problem of monolingual comparative normativity in (psycho) linguistic research on bilingualism. We argue that, in the vast majority of cases, juxtaposing (functional) monolinguals to bilinguals fails to offer what the comparison is supposedly intended to do: meet the standards of empirical control in line with th
This book offers a first look at transnational education corporations, new firms that operate international schools. The quiet rise of transnational education corporations – or TECs – has implications for education systems around the globe, as corporate interests gain a greater stake in the way schools operate. The story of their ascendance links government policies in one corner of the world with
The Gram-positive bacterium Bacillus subtilis contains two respiratory oxidases of the haem-copper superfamily: cytochrome aa(3), which is a quinol oxidase, and cytochrome caa(3), which is a cytochrome c oxidase. Cytochrome c oxidase uniquely contains a di-copper centre, Cu-A. B. subtilis CtaG is a membrane protein encoded by the same gene cluster as that which encodes the subunits of cytochrome c
There is compelling evidence that more diverse ecosystems deliver greater benefits to people, and these ecosystem services have become a key argument for biodiversity conservation. However, it is unclear how much biodiversity is needed to deliver ecosystem services in a cost-effective way. Here we show that, while the contribution of wild bees to crop production is significant, service delivery is
This article aims to undertake a comprehensive cost-benefit analysis of SSAB's investment in green steel production under the HYBRIT initiative, focusing on the implications of operating within the EU Emission Trade System and an illustrative scenario employing a carbon tax. The study evaluates profitability and social benefits, utilizing time series models to forecast electricity prices in di
This article aims to undertake a comprehensive cost-benefit analysis of SSAB's investment in green steel production under the HYBRIT initiative, focusing on the implications of operating within the EU Emission Trade System and an illustrative scenario employing a carbon tax. The study evaluates profitability and social benefits, utilizing time series models to forecast electricity prices in di
Background and purpose: Epstein–Barr virus (EBV) and human herpesvirus 6A (HHV-6A) are associated with increased risk of multiple sclerosis (MS). Conversely, infection with cytomegalovirus (CMV) has been suggested to reduce the risk of MS but supporting data from presymptomatic studies are lacking. Here, it was sought to increase the understanding of CMV in MS aetiology. Methods: A nested case–con
Companies enjoy increasingly extensive protection of their fundamental right to conduct business under EU law. This article will examine whether this protection is justified by reference to the foundational value of human freedom. In other words, does the way in which EU law protects the fundamental rights of companies to conduct business promote the freedom of individuals human beings within the
NAA10 is a major N-terminal acetyltransferase (NAT) that catalyzes the cotranslational N-terminal (Nt-) acetylation of 40% of the human proteome. Several reports of lysine acetyltransferase (KAT) activity by NAA10 exist, but others have not been able to find any NAA10-derived KAT activity, the latter of which is supported by structural studies. The KAT activity of NAA10 towards hypoxia-inducible f
Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin (HTT) gene. Skeletal muscle wasting alongside central pathology is a well-recognized phenomenon seen in patients with HD and HD mouse models. HD muscle atrophy progresses with disease and affects prognosis and quality of life. Satellite cells, progenitors of mature skeletal muscle fibers, are essential for proliferation,
