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Hu11B6 is a monoclonal antibody that internalizes in cells expressing androgen receptor (AR)-regulated prostate-specific enzyme human kallikrein-related peptidase 2 (hK2; KLK2). In multiple rodent models, Actinium-225-labeled hu11B6-IgG1 ([225Ac]hu11B6-IgG1) has shown promising treatment efficacy. In the present study, we investigated options to enhance and optimize [225Ac]hu11B6 treatment. First,

It has previously been shown that sera from multiparous women have increased levels of anti-idiotypic antibodies specific for anti-HLA molecules. γ-Globulins prepared from these sera may be superior to commercial preparations of intravenous γ-globulin (IVIg) for inhibiting HLA alloimmunization. To test this, F(ab′)2 fragments prepared from either commercial IVIg or from the sera of men or multipar

Tissue factor pathway inhibitor-2 (TFPI-2) has previously been characterized as an endogenous anticoagulant. TFPI-2 is expressed in the vast majority of cells, mainly secreted into the extracellular matrix. Recently we reported that EDC34, a C-terminal peptide derived from TFPI-2, exerts a broad antimicrobial activity. In the present study, we describe a previously unknown antimicrobial mode of ac

Introduction: Recent haemophilia treatment advances include new recombinant FVIII (rFVIII) products with improved pharmacokinetic (PK) properties that aim to reduce the burden of prophylaxis. These treatments are commonly referred to as extended half-life rFVIII products (EHL rFVIII). There is no uniform definition of what constitutes an EHL rFVIII. Such a definition would help physicians, patient

https://www.lu.se/evenemang/food-systems-transformations-sustainable-and-resilient-future - 2026-05-08

Background: Nigeria is a major contributor to the global malaria burden. The genetic diversity of malaria parasite populations as well as antibody responses of individuals in affected areas against antigens of the parasite can reveal the transmission intensity, a key information required to control the disease. This work was carried out to determine the allelic frequency of highly polymorphic Plas

IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are diseases characterized by IgA deposits in the kidney and/or skin. Both may arise after upper respiratory tract infections, but the pathogenic mechanisms governing these diseases remain unclear. Patients with IgAN (n = 16) and HSP (n = 17) were included in this study aimed at examining whether IgA-binding M proteins of group A streptococ

Complement C2 deficiency (C2D) is associated with immunological diseases and increased susceptibility to invasive infections caused by encapsulated bacteria such as Neisseria menigitidis. In this study we evaluate the immunogenicity of vaccination against N. menigitidis in C2D. C2D patients (n=22) and controls (n=52) were given a tetravalent meningococcal polysaccharide vaccine. Serum bactericidal

Objective. Antileukoproteinase (ALP) is a physiologic inhibitor of granulocytic serine proteases. The present study was undertaken to investigate its therapeutic benefit in an antibody-transfer model of erosive polyarthritis and to elucidate its potential to interfere with immune complex-dependent inflammatory pathways. Methods. Arthritis development was induced in male (BALB/c x B10.Q)F-1 mice by

Transplantation of allogeneic embryonic neural tissue is a potential treatment for patients with Parkinson's and Huntington's diseases. The supply of human donor tissue is limited, and alternatives such as the use of animal (e.g., porcine) donor tissue are currently being evaluated. Before porcine grafts can be used clinically, strategies to prevent neural xenograft rejection must be developed. Kn

24 maj 2025 15:00 till 16:30 | Teater I want to invite you to my performance. It’s nothing you haven’t seen before. Just my life. It's about me and you. About every word we exchanged. About every piece of paper you sent to my home. About that moment when I unfolded them, and my fingerprints touched yours.I’m the one who keeps showing up at your door. The one your dog wagged its tail at this mornin

https://www.lu.se/evenemang/maryam-hashempour-final-attachment-0 - 2026-05-08

On January 1, 2022, the first requirement regarding climate declarations was introduced. This mandate specified that all new buildings must include climate declarations during the construction phase, encompassing modules A1-A5. In 2025, limit values are also planned to be added for the existing modules included in the 2022 climate declarations. These required values will be implemented as a signif

Microsoft Word - Wahlgren Reimer Bergenståhl.doc Abstrakt—Det finns flera anekdotiska bevis för att lärare och studenter anser att det är stor skillnad på naturvetar- och ingenjörsstudenter. För att ge en utgångspunkt för diskussioner på detta tema presenterar vi här en undersökning av två studentgrupper kemitekniker och naturvetare som läst liknande organkemikurs med samma lärare. De första preli

https://www.lth.se/fileadmin/lth/genombrottet/konferens2008/M_Wahlgren__J_Reimer__B_Bergenstaahl.pdf - 2026-05-08