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Urinary osteocalcin as a marker of bone metabolism

Background: Osteocalcin (OC) is produced by osteoblasts during bone formation, and circulating OC has been used in clinical investigations as a marker of bone metabolism. OC is excreted into urine by glomerular filtration and can be found in urine as midmolecule fragments. Methods: We developed and evaluated three immunoassays (U-MidOC, U-LongOC, and U-TotalOC) for the detection of various molecul

Adsorption of cationic cellulose derivatives/anionic surfactant complexes onto solid surfaces. I. Silica surfaces

The effect of the anionic surfactant SDS (sodium dodecyl sulfate) on the adsorption behaviors of cationic hydroxyethyl celluloses (Polymer JR-125, JR-400, and JR-30M) and hydrophobically modified cationic cellulose (Quatrisoft LM-200) at silica surfaces in the presence of a 10 mM NaCl solution has been investigated by null ellipsometry. The adsorbed amount of LM-200 is found to be considerably lar

Cerebral energy metabolism during transient hyperglycemia in patients with severe brain trauma

Objective: To study whether transient hyperglycemia adversely affects cerebral energy metabolism in patients with severe traumatic brain lesions. Design and setting: Prospective, nonrandomized study in the neurosurgical intensive care unit of a university hospital. Patients: 108 patients treated for severe traumatic brain lesions. Interventions: All patients were treated according to neurosurgical

A decade of progress in understanding the structural basis of protein synthesis

The key reaction of protein synthesis, peptidyl transfer, is catalysed in all living organisms by the ribosome - an advanced and highly efficient molecular machine. During the last decade extensive X-ray crystallographic and NMR studies of the three-dimensional structure of ribosomal proteins, ribosomal RNA components and their complexes with ribosomal proteins, and of several translation factors

Maximal oxygen uptake versus maximal power output in children

Maximal oxygen uptake ([Vdot]O2max) is considered the optimal method to assess aerobic fitness. The measurement of [Vdot]O2max, however, requires special equipment and training. Maximal exercise testing with determination of maximal power output offers a more simple approach. This study explores the relationship between [Vdot]O2max and maximal power output in 247 children (139 boys and 108 girls)

Analysis of heart rate variability during exercise stress testing using respiratory information

This paper presents a novel method for the analysis of heart rate variability (HRV) during exercise stress testing enhanced with respiratory information. The instantaneous frequency and power of the low frequency (LF) and high frequency (HF) bands of the HRV are estimated by parametric decomposition of the instantaneous autocorrelation function (ACF) as a sum of damped sinusoids. The instantaneous

Jämförelse mellan bedömningsinstrumenten Bayley-4 och Nya Reynell

Syfte: Studiens syfte var att jämföra bedömningsinstrumentet Bayley-4 med Nya Reynell genom användning på barn i åldern 30–42 månader för att undersöka om de fångar upp samma aspekter av språklig förmåga. Vidare var studiens syfte att undersöka om Bayley-4 kan vara lämpligt att använda på logopedmottagningar. Metod: Deltagare bestod av fem barn inom åldersspannet. Barnen kom från två olika förskoAim: The purpose of the study was to compare the assessment instrument Bayley-4 and New Reynell Developmental Language Scales to investigate whether they capture the same aspects of language ability and furthermore if Bayley-4 could be suitable for use in Speech–Language Pathology Clinics. The study involved assessing children aged 30- 42 months. Method: Five children within the age range particip

Development of a CFD Methodology for Molten Salts in Heat Exchangers

Som vi har märkt på grund av de senaste årens höga elpriser är en jämn elproduktion från grön energi väldigt viktig. Solkraft där man lagrar energi i smält salt kan användas för att sprida ut eltillverkningen på alla dygnets timmar. Utvinningen av saltets energi är då högst betydelsefull och denna har undersökts genom effektiva och simpla flödessimuleringar i detta arbete. Dessa flödessimuleringaTo be able to meet the global energy demands, a steady supply of green energy is required, even during sun- or windless hours. Concentrated solar power is a useful alternative, which can produce and store green energy by heating a heat transfer fluid (HTF) and extracting its energy via a heat exchanger. One such category of HTF is molten salts, and to understand and be able to model the behaviour

Epidemiology and time trends of isolated greater tuberosity fractures from 1944 to 2020 – A cohort study in Malmö, Sweden

Background: Although up to 25% of proximal humeral fractures are isolated greater tuberosity fractures (IGTFs), comprehensive epidemiological data are lacking. Objectives: Describe the epidemiology and time trends of IGTF in Malmö, Sweden, 1944–2020. Methods: We identified IGTF in Malmö residents (≥18 years) by reviewing relevant radiology examinations during 17 sample years from 1944 to 2020. Fra

Prevalence and risk factors of feeding difficulties in children with delayed reconstruction of esophageal atresia : a Swedish nationwide study

Purpose: Children with delayed reconstruction of esophageal atresia (DREA) have a high risk of morbidity. The aim of this study was to determine the prevalence of feeding difficulties in children with DREA, differences to children with primary anastomosis (PA) and identify risk factors for feeding difficulties in children with DREA. Methods: Parents of 30 children with DREA, born 2001–2018, were r

Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP : Five-year follow-up of the NordCML007 study

Objectives: Treatment-free remission (TFR) has emerged as a treatment goal in chronic myeloid leukemia in the chronic phase (CML-CP). Attempts to increase proportion of patients achieving TFR include combination of tyrosine kinase inhibitors (TKI) and other drugs. Interferon-α in addition to TKI has shown promising efficacy but with dose-dependent toxicity and discontinuations. NordCML007 was init

Impact of Electrical Current on Single GaAs Nanowire Structure

The impact of electrical current on the structure of single free-standing Be-doped GaAs nanowires grown on a Si 111 substrate is investigated. Single nanowires have been structurally analyzed by X-ray nanodiffraction using synchrotron radiation before and after the application of an electrical current. The conductivity measurements on single nanowires in their as-grown geometry have been realized

The Seventeenth Data Release of the Sloan Digital Sky Surveys : Complete Release of MaNGA, MaStar and APOGEE-2 Data

This paper documents the seventeenth data release (DR17) from the Sloan Digital Sky Surveys; the fifth and final release from the fourth phase (SDSS-IV). DR17 contains the complete release of the Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey, which reached its goal of surveying over 10,000 nearby galaxies. The complete release of the MaNGA Stellar Library (MaStar) accompanies

Impact of Preoperative Symptoms and Revascularized Arterial Segment in Patients With Chronic Limb-Threatening Ischemia

Background: Little is known about the relative impact of the preoperative symptoms rest pain and tissue loss, and of the arterial segment revascularized, on amputation rate and mortality in patients with chronic limb-threatening ischemia (CLTI). We wanted to investigate this topic further. Method: This population-based observational cohort study involved 10 419 patients revascularized for CLTI in

Metabolic dysfunction-associated steatotic liver disease has become the most common cause of hepatocellular carcinoma in Sweden : A nationwide cohort study

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease globally, and can lead to hepatocellular carcinoma (HCC), a leading cause of cancer-related death. We aimed to determine the extent to which MASLD is an increasing cause of HCC in Sweden and to determine clinical characteristics associated with underlying MASLD. Using the Swedish quality re

Caregiving Quality Across Development and Secure Base Knowledge among Adolescents with a History of Institutional Care

Abstract: Secure base scripts are implicit schemas that guide perceptions, responses, and interactions by encapsulating expectations of support from attachment figures during distress. The current study investigated the impact of early institutional rearing and the causal effects of high-quality foster care following early deprivation on secure base scripts in adolescents who had experienced sever

Quantification of phthalate and DINCH metabolites in human urine and maternal breast milk : Assessing maternal body burden and infant exposure

Based on toxicological evidence, human exposure to phthalates (PHs) and diisononylcyclohexane-1,2-dicarboxylate (DINCH) may contribute to adverse health effects, especially during vulnerable developmental stages. To support the exposure assessment for this group of endocrine disruptors, we developed and validated a method for the analysis of 14 PH and 3 DINCH metabolites in human urine and materna