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BACKGROUND: Alzheimer's disease is characterized by an abnormal increase of phosphorylated tau (pTau) species in the CSF. It has been suggested that emergence of different pTau forms may parallel disease progression. Therefore, targeting multiple specific pTau forms may allow for a deeper understanding of disease evolution and underlying pathophysiology. Current immunoassays measure pTau epitopes

On February 23, 2022, The EU Commission published its Proposal for a Directive of the European Parliament and of the Council on Corporate Sustainability Due Diligence and amending Directive (EU) 2019/1937 (“CSDDD” or “the Proposal”). The purpose of the Proposal, to further the “Union’s transition to a climate-neutral and green economy in line with the European Green Deal and in delivering on the U

Importance: Novel plasma biomarkers, especially phosphorylated tau (p-tau), can detect brain tau aggregates in Alzheimer disease. Objective: To determine which plasma biomarker combinations can accurately detect tau pathological brain changes in Down syndrome (DS). Design, Setting, and Participants: The cross-sectional, multicenter Alzheimer's Biomarker Consortium-Down Syndrome study included adul

Background: Previous research has revealed a clear relationship between weight gain of persons and their metabolic diseases developing later. These studies have covered only short periods lasting 4–8 years. Our goal was to collect decades’ old and often life-long anthropometric data and correlate the figures with the presence of hypertension and diabetes or both. Methods: A retrospective internat

Context. Observational evidence indicates that the orbits of extrasolar planets are more various than the circular and coplanar ones of the solar system. Planet-planet interactions during migration in the protoplanetary disc have been invoked to explain the formation of these eccentric and inclined orbits. However, our companion paper (Paper I) on the planet-disc interactions of highly inclined an

Course syllabus H5F6056 From Research to ATMP Treatment - Process Development, Quality Assurance, Regulatory Affairs and Logistics Course syllabus Fubas 28/2025 University of Gothenburg DEPARTMENT OF LABORATORY MEDICINE H5F6056, From Research to ATMP Treatment - Process Development, Quality Assurance, Regulatory Affairs and Logistics, 3 credits (hec) Från forskning till ATMP terapi - processutveck

https://www.stemcellcenter.lu.se/sites/stemcellcenter.lu.se/files/2026-04/Course_syllabus_H5F6056.pdf - 2026-05-26

Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort RESEARCH ARTICLE Identification of Non-HLA Genes Associated with Celiac Disease and Country-Specific Differences in a Large, International Pediatric Cohort Ashok Sharma1, Xiang Liu2, David Hadley2,3, William Hagopian4, Edwin Liu5, Wei- Min Chen6, Suna Onengut-G

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/55%2006032016_679_55_Sharma_PlosOne_2016.pdf - 2026-05-26

BACKGROUND: – The clinical use of risk scores to guide treatment decisions and improve clinical outcomes has rarely been prospectively evaluated. This study aimed to evaluate whether a biomarker-based ABC-AF risk score–guided multidimensional treatment strategy improves long-term outcomes in patients with AF. METHODS: – The multicenter, registry-based, randomized, controlled, open-label study enro

Purpose: To describe the prevalence of neck pain (NP) and low back pain (LBP) of varying severity in older community-dwelling men, identify associated factors, and evaluate whether prevalent NP/LBP are risk factors for experiencing pain 5 years later. Patients and Methods: MrOS Sweden is a prospective observational study that included 3014 community-dwelling men aged 69–81 years, of whom 1962 atte

We investigated the relationship between nitric oxide (NO) and Na+,K+-ATPase (NKA) in the gill of anadromous Atlantic salmon. Cells containing NO-producing enzymes were revealed by means of nitric oxide synthase (NOS) immunocytochemistry and nicotinamide adenine dinucleotide phosphate diaphorase (NADPHd) histochernistry, which can be used as an indicator of NOS activity, i.e. NO production. Antibo

In a forest ecosystem at steady state, net carbon (C) assimilation by plants and C loss through soil and litter decomposition by heterotrophic organisms are balanced. However, a perturbation to the system, such as increased mean soil temperature, will lead to faster decay, enhancing CO2 release from decomposers, and thus upsetting the balance. Recent in situ experiments have indicated that the sti

A method for calculating the wave load induced fatigue damage accumulated by a vessel sailing along the North Atlantic route (NAr) is presented. This method is based on the Palmgren-Miner additive rule and the rainflow cycle (RFC) count. For simplicity, the load the vessel experiences is assumed to be proportional to the encountered significant wave height process, H-s. The asymptotically normal c

Microsoft Word - WHRCF2019_Call4Papers Call for Papers The 9th World Human Right Cities Forum 30th September (Mon) - 3rd October (Thu) 2019 Gwangju, Republic of Korea Local Governments, Human Rights and Sustainable Development: Reimagining Human Rights Cities The City of Gwangju is hosting the 9th World Human Rights Cities Forum. Since it was first held in 2011, World Human Rights Cities Forum has

https://rwi.lu.se/app/uploads/2019/07/whrcf2019-call-for-papers.pdf - 2026-05-26

Objectives: The optimal treatment of latent autoimmune diabetes in adults (LADA) is not established. We explored whether early insulin treatment, which has shown beneficial effects in rodents and in human pilot studies, would result in better preservation of beta-cell function or metabolic control, compared with conventional treatment. Subjects and methods: Glucagon-stimulated C-peptide and HbAlc

Endotoxin was measured in air and dust samples collected during four commercial aircraft flights. Samples were analyzed for endotoxin biological activity using the Limulus assay. 3-hydroxy fatty acids (3-OH FA) of carbon chain lengths C10:0-C18:0 were determined in dust by gas chromatography-ion trap tandem mass spectrometry. The geometric mean (geometric standard deviation) endotoxin air level wa

The ever increasing data rates in wireless communication require analog to digital converters (ADCs) with greater requirements on speed and accuracy, while being power efficient to prolong battery life. This dissertation contains an introduction to the field and five papers that focus on the continuous-time (CT) Delta-Sigma modulator (DSM) as ADC. Paper I analyses the performance degradation of d

There is increasing evidence that short-chain fatty acids (SCFA) formed by colonic fermentation of indigestible carbohydrates have beneficial physiological effects. Butyric acid is the main energy substrate for the colonic mucosa and has been implicated as important in the prevention and treatment of diseases of the colonic mucosa, such as distal ulcerative colitis and cancer. Propionic acid, on t

OBJECTIVES: To evaluate the outcome of treatment for deep sternal wound infection (DSWI) in a nationwide patient cohort, before and after the introduction of negative-pressure wound therapy (NPWT). METHODS: This was a population-based cohort of all patients treated for DSWI in Iceland out of 2446 open heart operations performed between 2000 and 2010. Length of hospital stay, survival and reoperati

In this study, we show a significantly reduced assay time and a greatly increased bead recovery for a commercial Luminex-based multiplex diagnostic immunoassay by performing all liquid handling steps of the assay protocol in a non-contact acoustic trapping platform. The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis vi