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In this 24-month follow-up of a phase II study in patients with castration-resistant prostate cancer (CRPC) and bone metastases, radium-223 (4 injections of 50 kBq/kg every 4 weeks [n = 33]) improved median overall survival vs. matching placebo (n = 31) (65.3 vs. 46.4 weeks, respectively; log-rank P = .056), with no long-term safety concerns. Data suggest that treatment of bone disease with radium

Background: Global stroke epidemiology is changing rapidly. Although age-standardized rates of stroke mortality have decreased worldwide in the past 2 decades, the absolute numbers of people who have a stroke every year, and live with the consequences of stroke or die from their stroke, are increasing. Regular updates on the current level of stroke burden are important for advancing our knowledge

Study Design. Multicenter randomized controlled trial.Objective. To compare the efficacy and safety of balloon kyphoplasty (BKP) to non-surgical management (NSM) over 24 months in patients with painful vertebral compression fractures (VCF).Summary of Background Data. Recently, several large randomized controlled trials have been conducted and reported how vertebral augmentation compares with NSM f

OBJECTIVE: The concordance index (c-index) is the standard way of evaluating the performance of prognostic models in the presence of censored data. Constructing prognostic models using artificial neural networks (ANNs) is commonly done by training on error functions which are modified versions of the c-index. Our objective was to demonstrate the capability of training directly on the c-index and t

Background: Out of Hospital Cardiac arrest (OHCA) survivors with ST elevation (STE) with or without shockable rhythms often benefit from coronary angiography (CAG) and, if indicated, percutaneous coronary intervention (PCI). However, the benefits of CAG and PCI in OHCA survivors with nonshockable rhythms (PEA/asystole) and no STE are debated. Methods: Using the International Cardiac Arrest Registr

Background: There are no conclusive results from randomized trials on radiotherapy (RT) versus radical prostatectomy (RP) for prostate cancer. Numerous observational studies have suggested that RP is associated with a lower risk of prostate cancer death, but whether results have been biased due to limited adjustments for confounding factors is unknown. Objective: To compare the risk of prostate ca

Introduction Intimate partner violence (IPV) is regarded an important public health and human rights issue, characterized by physical, sexual or emotional abuse. Globally more than one in three women report physical or sexual violence by their intimate partners. Though the association between IPV and depression is known, we found no study investigating depression as a risk factor for IPV and very

Background: The aim of this study was to describe out-of-hospital cardiac arrest (OHCA) survivors' ability to participate in activities of everyday life and society, including return to work. The specific aim was to evaluate potential effects of cognitive impairment. Methods and Results: Two hundred eighty-seven OHCA survivors included in the TTM trial (Target Temperature Management) and 119 match

PURPOSE: To investigate the incidence and causes of visual impairment in children born prematurely in Finland from 1972 through 1989, and to determine what conditions and factors were associated with its occurrence. DESIGN: Retrospective, cross-sectional study. SUBJECTS: All visually impaired individuals from 0 to 17 years of age who had been born at fewer than 37 gestational weeks in Finland from

Localization is an important enabling technology for many applications, such as wireless sensor networks, emergency rescue services, civil defense and transportation. Suppose that a room is equipped with several microphones (or sensors), and one person is making a sound while moving around in the room. Can one find microphone and sound source positions as well as reconstruct a room geometry? The a

Background Early life factors may predict cardiovascular disease (CVD), but the pathways are still unclear. There is emerging evidence of an association of early life factors with apolipoproteins, which are linked to CVD. The study objective was to assess the associations between birth variables and adult apolipoproteins (apoA1 and apoB, and their ratio) in a population-based cohort. Methods The L

Cancer är den näst vanligaste dödsorsaken i världen idag och en tredjedel av Sveriges befolkning blir diagnosticerade med cancer under sin livstid. Av alla cancerfall i Sverige, så är prostatacancer den vanligaste och bröstcancer den näst vanligaste, medan hos enbart kvinnor så är bröstcancer den vanligaste med 29,2 % av cancerfallen. Överlevnaden efter en cancerdiagnos har i Sverige ökat sedan 70Cells are commonly used in research to evaluate toxicity and efficiency of drugs. However, to further increase the usefulness of cells as well as the understandings of effects of different interventions, new methods must constantly be developed and refined. Today, many assays use end-point analysis of large populations of cells, to evaluate the research question. However, there are many cases when

Background: Bone Scan Index (BSI) derived from 2D whole-body bone scans is considered an imaging biomarker of bone metastases burden carrying prognostic information. Sodium fluoride (NaF) PET/CT is more sensitive than bone scan in detecting bone changes due to metastases. We aimed to develop a semi-quantitative PET index similar to the BSI for NaF PET/CT imaging and to study its relationship to BS

Popular science summary: An MK-801 Hyperactivity Model in Zebrafish Larvae Schizophrenia is a mental disorder characterized by psychosis, depression and cognitive impairments. The severity of this disease is easily underestimated, since the manifestations are not consequently lethal. Additionally, Schizophrenia is correlated with a 50 times increased risk of attempted suicide. Considering that a

Pupils have gotten school meals in Sweden since the late 1800´s. The school meal has of course changed over the years. In the beginning the pupils only got porridge and milk. Since then they serve both meat-, fish- and chicken dishes. In recent years, many schools around the country are more concerned about the environment and therefore started to serve more plant-based diets and less red meat. Re

Background: Severe left-sided cardiac obstructions are associated with high morbidity and mortality if not detected in time. The correct prenatal diagnosis of coarctation of the aorta (CoA) is difficult. Fetal cardiac magnetic resonance imaging (CMR) may improve the prenatal diagnosis of complex congenital heart defects. Flow measurements in the ascending aorta could aid in predicting postnatal Co

BACKGROUND: The benefit:risk profile of bivalirudin versus heparin anticoagulation in patients with non-ST-segment-elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) is uncertain. Study-level meta-analyses lack granularity to provide conclusive answers. We sought to compare the outcomes of bivalirudin and heparin in patients with non-ST-segment-elevation myocardial

Paul McMillan Lund Observatory, Box 43 SE-221 00 Lund, Sweden +46 46 22 27312 paul@astro.lu.se EDUCATION University of Leicester, Department of Physics and Astronomy 2003-2006 PhD in Theoretical Astrophysics, awarded 2007 Thesis title: Numerical simulations of galaxy interaction Supervisor: Prof Walter Dehnen Included three-month Marie Curie fellowship at Observatoire de Marseille, Université d

https://www.astro.lu.se/sites/astro.lu.se/files/2022-06/McMillan_CV_and_PublicationList_0.pdf - 2026-06-01

Kommers-guide: Direktupphandling Ctrl+klicka här för support 1 Senast uppdaterad: 2026-05-22 Innehåll Innehåll ....................................................................................................................................... 1 Om guiden .............................................................................................................................. 4 Del 1 – Dire

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2026-05/Kommers-guide-direktupphandling.pdf - 2026-06-01

publication_rinne Publications, Janne Rinne January 25, 2021 1 List of publications Summary: 113 papers in peer-reviewed journals, 4 book chapters, 1 lecture material (and revised new edition), 2 articles in professional journals, numerous non-peer-reviewed publications (conference abstracts, reports, etc.) Publications in peer-reviewed journals 113. Cai, Z., S. Junttila, J. Holst, H. Jin, J. Ardö

https://www.nateko.lu.se/sites/nateko.lu.se/files/2021-02/publication_rinne.pdf - 2026-06-01