Filetype
Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of lysine 27 on histone 3 (H3K27me3). H3K27me3 is characteristic of the chromatin at genes involved in developmental regulation in undifferentiated cells. Overexpression of EZH2 has been found in several cancer types such as breast, prostate, melano
Background: Children with Down syndrome (DS) have an increased risk for acute lymphoblastic leukemia (ALL). Although previous studies have shown that DS-ALL differs clinically and genetically from non-DS-ALL, much remains to be elucidated as regards genetic and prognostic factors in DS-ALL. Methods: To address clinical and genetic differences between DS-ALL and non-DS-ALL and to identify prognosti
Wnt-5a protein expression in primary tumors from unselected breast cancer patients has revealed a tumor suppressive function of the protein. However, in vitro experiments on human breast cancer cells have reported contradictory results, indicating both a tumor suppressive and promoting functions of Wnt-5a. This could be due to various functions of Wnt-5a in different subgroups of patients. The uns
Purpose The aim of this study was to find clinically relevant MIBG-avid metastatic patterns in patients with newly diagnosed stage 4 neuroblastoma. Methods Diagnostic I-123-MIBG scans from 249 patients (123 from a European and 126 from the COG cohort) were assessed for metastatic spread in 14 body segments and the form of the lesions: "focal" (clear margins distinguishable from adjacent background
In the fields of medicine and biology, the separation of particles is a central step in many preparative and analytical processes. Deterministic Lateral Displacement (DLD) has been a promising technique in the field of microfluidic particle and cell sorting, specifically for label-free separation with several applications of sorting by size, morphology, and deformation reported in the literature o
Background: Late effects induced by radiotherapy (RT) are of great concern for mediastinal Hodgkin’s lymphoma (HL) patients and it is therefore important to reduce normal tissue dose. The aim of this study was to investigate the impact on the normal tissue dose and target coverage, using various combinations of intensity modulated proton therapy (IMPT), volumetric modulated arc therapy (VMAT) and
Background. T-cell lymphoblastic lymphoma (T-LBL) is a rare neoplasm of precursor lymphoblast origin, for which there is no standard treatment for adults. Results of current treatment strategies in selected populations do exist but are largely unreported for unselected series. Here, we aimed to investigate treatment outcome in a population-based cohort. Material and methods. Patients were identifi
Background. The SWENOTECA IV protocol from 1995 is a prospective population-based study in metastatic non-seminomatous germ cell testicular cancer (NSGCT), designed for early identification of patients with poor response to standard cisplatin-based chemotherapy. A slow tumor marker decline (HCG T(1/2) > 3 days, AFP T(1/2) > 7 days) after BEP or BEP plus ifosfamide was regarded as poor response. Th
Recent studies show that mantle cell lymphoma (MCL) express aberrant miRNA profiles, however, the clinical effect of miRNA expression has not previously been examined and validated in prospective, large, homogenously treated cohorts. We analyzed diagnostic MCL samples from the Nordic MCL2 and MCL3 clinical trials, in which all patients had received Rituximab-high-dose cytarabin alternating with Ri
BACKGROUND: Oxygen free radicals (OFRs), platelet activating factor (PAF), cell adhesion molecules, and transmigration of polymorphonuclear leukocytes through the gut barrier are probably all essential in the development of gut barrier dysfunction following intestinal ischemia and reperfusion (I/R). Pretreatment and early treatment of I/R with the OFRs-scavenger (NAC), the PAF inhibitor lexipafant
Background:Although many low-penetrant genetic risk factors for breast cancer have been discovered, knowledge about the effect of multiple risk alleles is limited, especially in women <50 years. We therefore investigated the association between multiple risk alleles and breast cancer risk as well as individual effects according to age-approximated pre- and post-menopausal status.Methods:Ten previo
Bilaga 1 - Fördelning av ansvar och beslutsbefogenheter samt delegationer inom CEC, beslut 2020-04-28, STYR 2020/407 1 Fördelning av ansvar och beslutsbefogenheter samt delegationer inom CEC från och med 2020-05-01 Föreståndare Motsvarar prefekt, se gällande chefskontrakt och gällande arbetsordning vid naturvetenskapliga fakulteten. Övergripande formellt ansvar och övergripande verksamhetsansvar.
Rapport luPOD Lunds universitet | sektionen personaL 2014-03-14 Tack Vi i programledningen vill rikta ett stort tack till alla medarbetare, gäster, dekaner, prefekter, mentorer och deltagare som bidragit till luPOD! Ett program av detta slag byggs inte av en styrgrupp. På samma sätt som ett universitet byggs av alla människor som bidrar på olika sätt till helheten! Cecilia Agrell Johan Mauritsson
https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/rapport-lupod-140314.pdf - 2025-12-02
pnas201305623 1..10 TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity Mickael Decressaca,1, Bengt Mattssona, Pia Weikopb, Martin Lundblada, Johan Jakobssona, and Anders Björklunda,1 aDepartment of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden; and bLaboratory of Neuropsychiatry, Rigshospitalet University Hospita
https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/decressac_et_al._pnas_2013.pdf - 2025-12-02
CFEWP55 CFE Working Papers series No.55 CFE Working Papers are available at the website of the Centre for European Studies www.cfe.lu.se Soft Europeanisation of Work-Family Reconciliation Policy-Making? Social, Policy and Political Learning among German MPs Alisa Gühlstorf 2 Alisa Gühlstorf holds a M. Sc. in Welfare Policies and Management from Lund University and this paper is her graduate thesis
https://www.cfe.lu.se/en/sites/cfe.lu.se.en/files/2020-12/cfewp55.pdf - 2025-12-02
Programme syllabus Bachelor of Science Programme in Development Studies Faculty of Social Sciences SGUTV, Bachelor of Science Programme in Development Studies, 180 credits Kandidatprogram i utvecklingsstudier, 180 högskolepoäng First cycle degree programme not requiring previous university study / Program utan akademiska förkunskapskrav och med slutlig examen på grundnivå Decision The programme sy
https://www.keg.lu.se/en/sites/keg.lu.se.en/files/2024-01/SGUTV-programme-syllabus-2020%20(1).pdf - 2025-12-02
Malawi PEA report A Political Economy of Inclusion in Agricultural Intensification Malawi Country Report Anna Mdee1, Michael Chasukwa2, Darlen Dzimwe3 & Alesia Ofori Dedaa4 January 2018 Reviewed by Agnes Andersson Djurfeldt 1 University of Leeds/Overseas Development Institute, UK 2 University of Malawi 3 University of Malawi 4 University of Leeds, UK ii Pa ge ii “Agricultural intensification has b
https://www.keg.lu.se/en/sites/keg.lu.se.en/files/malawi_pea_report.pdf - 2025-12-02
Stress, Over-consumption and Climate Change Can humans manage climate change if social norms would include the significance of attachment, altruism, long term global thinking and local action? by Annika Tibblin symbolica.tibblin@gmail.com MASTER OF SUSTAINABLE AND ENVIRONMENTAL SCIENCE May 2008 A Thesis Submitted to Lund University in partial fulfilment of the requirements for the degree Lund Univ
https://www.lumes.lu.se/sites/lumes.lu.se/files/annika_tibblin.pdf - 2025-12-02
Density-dependent reproductive output in relation to a drastically varying food supply: getting the density measure right Åke Lindström, Anders Enemar, Göran Andersson, Ted von Proschwitz and N. Erik I. Nyholm Lindström, Å., Enemar, A., Andersson, G., von Proschwitz, T. and Nyholm, N. E. I. 2005. Density-dependent reproductive output in relation to a drastically varying food supply: getting t
https://www.luvre.lu.se/sites/luvre.lu.se/files/luvre-1322005lindstrometalbramblingepirrita.pdf - 2025-12-02
