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Popular science summary: NADase – a way to avoid immune system activation? Streptococcus pyogenes (S. pyogenes) are bacteria that cause many different kinds of diseases in humans, for example strep throat, scarlet fever and necrotizing fasciitis, the ”flesh-eating disease”. An infection with this type of bacteria can also lead to heart and kidney damage, thought to be caused by our immune system
Populärvetenskaplig sammanfattning: Är klimatforskningen skev? En central fråga är om vi kan lita på att vetenskapliga tidskrifter återger en rättvis bild av aktuella forskningsresultat? Dessutom bör vi fråga oss hur rapporteringen påverkas då betydande händelser sker inom vetenskapsvärlden. I november 2007 och senare 2009 skedde två viktiga företeelser inom klimatforskningen som potentiellt kanAbstract The declaration of a scientific consensus concerning anthropogenic causes for climate change by the IPCC in their fourth assessment report (AR4), published in 2007, initiated a heated debate. During this debate, experts within the IPCC were accused of selective reporting and the AR4 got strong source criticism by politicians, stakeholders and climate skeptics in general. The debate furth
The alternating between dry and wet seasons and the consecutive microbial responses to soil water content in semiarid ecosystems has significant consequences on nitrogen exchanges with the atmosphere. Three field campaigns were carried out in a semi arid sahelian rangeland in Dahra (Ferlo, Senegal), two at the beginning of the wet season in July 2012 and July 2013, and the third one in November 20
Summary: In community dwelling, 75-year-old women followed 10 years, a frailty index was created at each of three visits. Frailty score increased by ~ 6–7% annually. A higher frailty score was equivalent to being 5–10 years chronologically older. Frailty was associated with low bone density and higher risk of dying. Introduction: To understand the distribution of frailty among a population-based s
Skeletal development is heterogeneous. Throughout growth, bone size is more maturationally advanced than the mineral being accrued within its periosteal envelope; before puberty, appendicular growth is more rapid than axial growth; during puberty, appendicular growth slows and axial growth accelerates. We studied women with differing age of onset of anorexia nervosa to determine whether this tempo
BACKGROUND: Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in Blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an acute compensatory mechanism when there is a disruption in volume-loading homeostasis, i.e. when cardiac stress is evident. Whether DefS will influence associations between copepti
We report the discovery and characterization of two sub-Saturns from the Transiting Exoplanet Survey Satellite (TESS) using high- resolution spectroscopic observations from the MaHPS spectrograph at the Wendelstein Observatory and the SOPHIE spectrograph at the Haute-Provence Observatory. Combining photometry from TESS, KeplerCam, LCOGT, and MuSCAT2, along with the radial velocity measurements fro
BACKGROUND: The transition to undertaking rehabilitation in the home or local neighbourhood calls for an extensive understanding of which aspects of the built environment are important for people with stroke.OBJECTIVE: This qualitative study aims to explore how home and local neighbourhood environments support or hinder rehabilitation for people who have had a stroke from the perspectives of vario
Background: Experiments have shown improved cardiovascular stability in lambs if umbilical cord clamping is postponed until positive pressure ventilation is started. Studies on intact cord resuscitation on human term infants are sparse. The purpose of this study was to evaluate differences in clinical outcomes in non-breathing infants between groups, one where resuscitation is initiated with an in
The problem of antibiotic resistance is rising continuously, creating a warning signal that calls for finding alternatives. Not only that, but there is also a rising demand for natural food preservatives. The pharmaceutical and food industry sectors are working on fulfilling these needs. This thesis is exploring possible solutions to these issues. The research studies presented here introduce the
Background: Endocrine disrupting chemicals (EDCs) are xenobiotics with the ability to interfere with hormone action, even at low levels. Prior environmental epidemiology studies link numerous suspected EDCs, including phthalates and bisphenol A (BPA), to adverse neurodevelopmental outcomes. However, results for some chemicals were inconsistent and most assessed one chemical at a time. Objectives:
Summary: We studied the risk for hip fracture before and after total knee replacement (TKR) in the entire population in Sweden. Women and men had a low risk for hip fracture before TKR but an increased risk the first year after TKR. Purpose: It is known that osteoarthritis is associated with high bone mass. We therefore studied the risk of hip fracture before and after total knee replacement (TKR)
Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. Gene therapy has been suggested to be a promising approach to target drug-resistant focal epilepsy si
Biological effects of electromagnetic fields (EMF) on the blood‐brain barrier (BBB) can be studied in sensitive and specific models. In a previous investigation of the permeability of the blood‐brain barrier after exposure to the various EMF‐components of proton magnetic resonance imaging (MRI), we found that the exposure to MRI induced leakage of Evans Blue labeled proteins normally not passing t
Wohlers Associates, Inc., recognized widely as the leading consulting firm and preeminent authority on additive manufacturing and 3D printing worldwide—terms that are used interchangeably—today announced the publication of the Wohlers Report 2016. The 2016 edition marks the 21st consecutive year of its availability. According to Wohlers Report 2016, the additive manufacturing (AM) industry, consis
BACKGROUND: The risk of spinal haematoma in patients receiving epidural catheters is estimated using routine coagulation tests, but guidelines are inconsistent in their recommendations on what to do when results indicate slight hypocoagulation. Postoperative patients are prone to thrombosis, and thromboelastometry has previously shown hypercoagulation in this setting. We aimed to better understand
AbstractBackgroundThere is a need for easily administered objective tests in neurodevelopmental disorders. We investigated the clinical utility for child and adolescent psychiatry of Auditory Brainstem Response (ABR) and Cambridge Neuropsychological Test Automated Battery (CANTAB) as support in diagnosing attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). MethodsTh
Aims/hypothesis: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity o
BACKGROUND AND PURPOSE: Raised plasma concentrations of tumor necrosis factor receptors (TNFR) have been linked to arterial stiffness, cerebral microbleeds, and vascular events. The aim of this study was to investigate the association of circulating levels of TNFR1 and TNFR2 with risk for future intracerebral hemorrhage (ICH).METHODS: The population-based MDCS cohort (Malmö Diet and Cancer Study;
Objective. To determine the concentrations of aggrecan fragments in synovial fluid from patients with knee joint injury, osteoarthritis (OA), or acute pyrophosphate arthritis (PPA; pseudogout), and to test their relative reactivity with the 846 epitope, a putative marker of cartilage aggrecan synthesis. Methods. Samples of knee joint fluid from 385 patients and 9 healthy-knee volunteers were obtai
