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Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami

Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat

Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T

Ord i mörkret Version 2 % α 33 ιœ Det œ œµ œ∀ œ œ œ bor så myc ket i D m G/D A œ œ∀ œ œ œµ or den, de är E/D A/C∀ œ œ œ œµ œ∀ œ fyll da av sa go lik D m G ˙∀ Œ ‰ ιœ kraft. Är A - - - - - % α5 œ œµ œ∀ œ œ liv li nor na på D m G/D œ œ∀ œ ‰ ιœµ jor den, de E/D A/C∀ œ œ œ œµ œ œ∀ bäs ta vi nå gon sin D m G A ˙ Œ œ haft. De D m C 7 - - -- - - - % α9 œ œ œ œ œ föl jer oss ge nom F C/F B œ œ œ œ œ œ å re

https://www.mhm.lu.se/sites/mhm.lu.se/files/2022-04/Ord%20i%20mo%CC%88rkret%20%20-%20obligatorisk%20sa%CC%8Ang%20acapella%20Sa%CC%8Ang%20GF%202022_0.pdf - 2025-10-15

Popular Abstract in Swedish Vår forskningsgrupp har tidigare påvisat kraftiga förändringar i genuttryck för neurotrofiner, en familj av tillväxtfaktorer för nervceller, och deras receptorer i kortikala och hippokampala nervceller vid olika hjärnskador. Det är till stora delar okänt vilken funktion neurotrofiner har efter hjärnskador, men neurotrofinsvaret skulle kunna vara en skyddande mekanism ocThis study explores the role of brain-derived neurotrophic factor (BDNF) for neuronal vulnerability and neurogenesis following cerebral ischemia in the rat. Cerebral ischemia results in selective neuronal cell loss in specific brain regions. We here demonstrate the rank order of vulnerability in two regions affected by global forebrain ischemia, i.e., hippocampus and striatum, by combining specifi

Friction Models and Friction Compensation Karl J. Åström Department of Automatic Control Lund University 1. Introduction 2. Friction Models 3. The LuGre Model 4. Effects of Friction on Control Systems 5. Friction Compensation 6. Summary Introduction ◮ Essential in Motion Control ◮ Classics Leonardo da Vinci (1452-1519 Amontons 1699 Coulomb 1785 ◮ Tribology ◮ Control ◮ Physics AFM ◮ Surface force a

https://www.control.lth.se/fileadmin/control/Education/DoctorateProgram/PhysicalModeling/Lectures/L6-FrictionModelseight.pdf - 2025-10-14

Angiogenesis is a hallmark of cancer and is now a validated therapeutic target in the clinical setting. Despite the initial success, anti-angiogenic compounds impinging on the vascular endothelial growth factor (VEGF) pathway display limited survival benefits in patients and resistance often develops due to activation of alternative pathways. Thus, finding and validating new targets is highly warr

In this paper, the authors show that liquid-liquid partition chromatography in an aqueous two-phase system offers unique possibilities of comparing the overall surface properties of intact antibodies in solution before and after binding of antigen. The authors demonstrate that the surface properties of antigen-antibody complexes are dependent on the variable regions of the antibodies, the nature o

A new type of continuous, supermacroporous, monolithic, cryogel affinity adsorbent was developed, allowing specific fractionation and separation of human peripheral blood lymphocytes in a chromatographic format. The affinity adsorbent was used to design a novel cell separation strategy, which was based on the interaction of protein A from Staphylococcus aureus with cells bearing IgG antibodies on

MSH2 rearrangements are involved in approximately 10% of hereditary non,polyposis colorectal cancer (HNPCC) families, and in most of the rearrangements, exon I is deleted. We scanned by quantitative multiplex polymerase chain reaction (PCR) of short fluorescent fragments (QMPSF) 200 kb of genomic sequences upstream of the MSH2 transcription initiation site in 21 HNPCC families with exon I deletion

Accomodation in Lund Hotels in Lund can be found through the home page of Visit Lund: http://www2.visitlund.se/en/accommodation There are of course also other booking sites that list hotels in Lund, such as e.g. hotels.com or booking.com. If you have problems finding a hotel room via the links provided above, you can also try go directly to Hotel Finn, where rooms have been pre-reserved for the co

https://www.msf.lu.se/sites/msf.lu.se/files/accomodation_in_lund_v2.pdf - 2025-10-15

Råttan är en däggdjursart med en kort dräktighetstiden och föds därför mycket omogen. Den är vid födelsen naken, blind och döv och är helt beroende av sin moder för många funktioner, såsom näringstillförsel, termoreglering, urinering och tarmtömning. Under diperioden är råttans mag-tarmsystem och matsmältning helt anpassad till modersmjölkdieten. Bland annat är tarmens barriärfunktion omogen, vilk

Protein D, a novel surface protein of the bacterial species Haemophilus influenzae with affinity for human IgD, was isolated after solubilization with sonication and Sarcosyl-extraction by a single SDS-PAGE step. From 1 ml of packed bacteria was prepared 0.25 mg of purified protein D. The apparent m.w. of protein D was estimated to 42,000 by SDS-PAGE and gel chromatography. Edman degradation cycle

The integrin CD103 and the chemokine receptor CCR9 are co-expressed on small intestinal CD8+ intraepithelial lymphocytes (IEL), naïve murine CD8+ T cells and by a small population of effector/memory CD8+ T cells, indicating a potential role for CCR9 in regulating CD103 expression and function. Here, we demonstrate that CD103, in contrast to CCR9, is down-regulated on CD8+ T cells following their a

Lundblad A-M, Hansson K. Relational problems and psychiatric symptoms in couple therapyInt J Soc Welfare 2005: 14: 256 -264 c Blackwell Publishing, 2005.This article describes couples attending family counselling in Sweden. The study group is compared with clinical groups and non-clinical groups. Self-rating instruments were com-pleted by 317 women and 312 men to evaluate the following: marital sa