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Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. Using cell culture, animal and patient studies, we investigated the biological role of microRNA-96 (miR-96) and microRNA-379

A high acoustic energy density is required in the acoustic resonator to increase the throughput of acoustophoresis devices. In this study, through both experiments and numerical simulations, we find that the energy density in bulk-wave-acoustophoresis devices can be enhanced by actuating the device from the side. Based on qualitative free-flow focusing experiments, side actuation shows clear super

Literature and experience show that there are large discrepancies between the calculated and measured building energy usages, where user-related parameters are significant factors with regard to energy use in low-energy buildings. Furthermore, the difficulties encountered when quantifying these parameters compound these discrepancies. The main aim of this study was to provide feedback that would h

Context. The HR 1614 is an overdensity in velocity space and has for a long time been known as an old (2 Gyr) and metal-rich ([Fe=H] +0:2) nearby moving group that has a dissolving open cluster origin. The existence of such old and metal-rich groups in the solar vicinity is quite unexpected since the vast majority of nearby moving groups are known to be young. Aims. In the light of new and signifi

Single top-quark production in association with a Z boson, where the Z boson decays to a pair of charged leptons, is measured in the trilepton channel. The proton-proton collision data collected by the ATLAS experiment from 2015 to 2018 at a centre-of-mass energy of 13 TeV are used, corresponding to an integrated luminosity of 139 fb−1. Events containing three isolated charged leptons (electrons o

Objective: To study whether a revision of CTG guidelines and educational program influenced the perceived need for intervention by residents in obstetrics and gynecology. A secondary aim was to study the sensitivity and specificity of the classification pathological after classification by residents using two different guidelines in identifying neonates with acidemia. Study design: Cardiotocograms

Background: Population-based register data could be used to improve our knowledge of patients surgically treated for foot and ankle disorders. The quality register Swefoot was recently created to collect surgical and patient-reported data of foot and ankle surgery. This manuscript aims to describe the development and current use of the register. Methods: The development of Swefoot started in 2014

Linear chromosomes of eukaryotic cells require the presence of functional nucleoprotein terminal structures, known as telomeres, to protect the integrity of the genome. The telomere is a highly dynamic and regulated structure constituted by short tandem DNA repeats rich in guanine nucleotides that extent as double-stranded DNA ending in a single-stranded 3′ overhang. An abundant number of proteins

Background: Contemporary data on stroke epidemiology and the availability of national stroke clinical registries are important for providing evidence to improve practice and support policy decisions. Aims: To update the most current incidence, case-fatality, and mortality rates on stroke and identify national stroke clinical registries worldwide. Methods: We searched multiple databases (based on o

We optimize traffic signal timing sequences for a section of a traffic net- work in order to reduce congestion based on anticipated demand. The system relies on the accuracy of the predicted traffic demand in time and space which is carried out by a neural network. Specifically, we design, train, and evaluate three different neural network models and assert their capability to describe demand from

This thesis consists of four self-contained papers in applied microeconomics with family as a common theme. The first paper documents how the financial portfolios of parents change in response to the birth of a child. To identify dynamic effects around child birth, we use an event study approach with a matched treatment and control sample and a novel implementation of the same sex instrument. We f

The current fossil-based economy must be transformed into a bio-based circular economy. A cornerstone of this transformation is the conversion of pulp and paper mills into lignocellulosic biorefineries that allow not only the production of pulp, paper, and electricity, but also novel biochemicals. Highly selective, electrifiable, and low-energy-consuming separation technologies will be key in the

Popular Abstract in Swedish Svenska lägenhetshushåll genererar i snitt 2.8-3.4 kg matavfall per vecka. Allt fler svenska kommuner har under senare år valt att införa separat insamling och biologisk behandling av matavfall. Den främsta anledningen till detta var det miljömål som syftade till att 35 % av matavfallet från hushåll, restauranger och storkök enligt riksdagens miljömål skulle behandlas bAn increased understanding of the world’s limited resources and the negative environmental impacts connected to solid waste management has in recent years increased interest in separate collection and treatment of organic waste in many parts of the world. As an example, increased biological treatment of organic waste is an explicit goal within the Swedish national solid waste management strategy (

Ischemic heart disease is the leading cause of death in high-income parts of the world and is caused mainly by atherosclerosis in the coronary arteries. The rupture of an atherosclerotic plaque with subsequent platelet activation and clot formation can lead to myocardial infarction (MI). Atherosclerosis is a complex process, which involves the accumulation and oxidation of low-density lipoprotein

Abstract This study tested the effect of environmental concentrations of the selective serotonin reuptake inhibitor (SSRI) sertraline on the life history of Daphnia magna and how individual-level responses could predict effects on population growth rate. Individual-level responses related to reproduction, growth and feeding were quantified in a 39-day bioassay and used in a life-table matrix. Alt

Vid fysisk planering genom upprättande och antagande av planer analyseras hur mark- och vattenområden ska användas i framtiden. Detaljnivå och rättslig status varierar mellan plantyperna, några är rättsligt bindande medan andra är vägledande. I Sverige är makten över markanvändningsplaneringen decentraliserad, kommunerna har huvudansvaret för planeringen. Genom länsstyrelsen bevakas statens intresPhysical planning by establishing and adopting plans enables analysis of future land and water use. The level of detail and legal status varies between the different types of plans; some are legally binding while others are guiding and non-binding. Land use planning in Sweden is decentralized and municipalities carry the main responsibility for planning. Matters of national interest are watched ov

Sammanfattning Det immaterialrättsliga ersättningssystemet är förmodligen mer aktuellt än någonsin. Ett ökat internationellt fokus och de förändringar som bland annat IPRED-direktivet medfört är en del i detta. Dessutom har den tekniska utvecklingen under en period varit stor, sammantaget innebär detta att frågan om ersättning för immaterialrättsintrång är mycket angelägen. Immateriella rättighetSummary The sanctioning of infringements into intellectual properties is a question of severe relevance. Technical development, globalization and legal standpoints such as the Intellectual Property Rights Enforcement Directive has made the topic of this paper a much debated one. The value of intellectual properties can be immense. In fact there are quite a few cases where the most valued assets