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This thesis presents the design and schematic-level simulation of a highly linear mixer-first receiver front-end implemented in CMOS, targeting improved robustness against strong input signals. The proposed architecture employs a current-mode passive mixer directly loaded by a low-impedance transimpedance amplifier (TIA) in order to minimize the voltage swing at the mixer output and thereby enhanc
Heavy-duty trucks, especially those used in urban areas, are responsible for a disproportionally large share of the external costs of the transportation sector. Policy instruments that target these trucks could thus be efficient measures to reduce negative impact from the traffic sector. This paper presents how heavy-duty trucks operated in Sweden’s two largest cities, Gothenburg and Stockholm, in
Distillation is the primary separation technique in the petrochemical industries, but it operates with extremely low thermodynamic efficiency. It represents the largest share of industrial energy consumption, making its decarbonization a global priority. While advanced process technologies, such as Mechanical Vapor Recompression (MVR) and the Heat-Integrated Distillation Column (HIDiC), offer a pa
Direct-to-Device (D2D) communication in Non-Terrestrial Networks (NTNs) enables smartphones to connect directly to satellites, extending wireless coverage beyond terrestrial networks. This thesis presents the design of a smartphone antenna optimized for NTN operation, followed by a link budget analysis and Electromagnetic Field (EMF) exposure assessment. The proposed solution is a dual-band circu
Spiral galaxies host elongated filamentary structures of dense gas and dust, known as feathers, which branch off the main spiral arms into the interarm regions and are associated with star formation. The physical mechanisms governing their formation remain debated, with magnetic fields proposed as one of the contributing factors. This thesis investigates the role of magnetic fields in feather form
Background Overweight, defined by body mass index (BMI), is correlated to complications following pancreaticoduodenectomy (PD). The aim of this study was to evaluate the impact of body constitution, measured with different anthropometric measures, and diabetes on complications following PD. Materials and methods Patients who underwent PD between 2000 and 2015 at Skåne University Hospital were retr
Introduction: Serum lactate is considered to be a marker of tissue hypoxia (1) Cut-off values >4 mM predict poor outcome, yet many patients after resuscitation according Surviving Sepsis Campaign guidelines (SSCG) (2) have high mortality despite decreases in blood lactate. Our hypothesis was that dynamic, rather than absolute blood lactate concentrations predict survival. Further we tested the abi
Background: Lack of a global consensus on the definition of advanced Parkinson’s disease (APD) and considerations for timing of device-aided therapies may result in heterogeneity in care. Objectives: To reach consensus among movement disorder specialists regarding key patient characteristics indicating transition to APD and guiding appropriate use of device-aided therapies in the management of PD
In order to generate high voltage high pulsed power, klystron modulators necessarily contain at least one capacitor bank charging structure supplying the energy to be released during the pulse. Conventional charging structures are based on AC/DC front-end units typically based on diode rectifiers combined with on/off controlled power charging structures as a second stage, producing prohibitive lev
External Thermal Insulation Composite Systems (ETICS) represent a popular modern facade for reducing energy consumption, particularly in retrofit applications. Insulation - typically in the form of either EPS (expanded polystyrene) or mineral wool - is applied to the exterior of buildings using mortar adhesive, and then coated with a final layer of sand-cement render and glass fibre reinforcement.
Dense time series of Landsat 8 and Sentinel-2 imagery are creating exciting new opportunities to monitor, map, and characterize temporal dynamics in land surface properties with unprecedented spatial detail and quality. By combining imagery from the Landsat 8 Operational Land Imager and the MultiSpectral Instrument on-board Sentinel-2A and -2B, the remote sensing community now has access to modera
The activity and operational stability of horse liver alcohol dehydrogenase (HLADH) and αchymotrypsin were investigated in three systems commonly used for biocatalysis in organic solvents: 1. enzyme adsorbed on a solid support (celite) and added to the organic solvent (isooctane) 2. enzyme powder directly added to the organic solvent (isooctane). 3. enzyme dissolved in a microemulsion (AOT/isoocta
Early caregiving is one of the strongest influences on children's development, and among the most significant modifiable environmental factor. The aim of this study was to explore the association between quality of caregiver-infant interactions and neurodevelopment of infants living in banana-growing communities in rural Costa Rica characterized as having environmental toxic exposures. Home visits
Background: Full-term pregnancy (FTP) is associated with a reduced breast cancer (BC) risk over time, but women are at increased BC risk in the immediate years following an FTP. No large prospective studies, however, have examined whether the number and timing of pregnancies are associated with BC risk for BRCA1 and BRCA2 mutation carriers.Methods: Using weighted and time-varying Cox proportional
Research on the effects of climate change in the marine environment continues to accelerate, yet we know little about the effects of multiple climate drivers in more complex, ecologically relevant settings - especially in sub-tropical and tropical systems. In marine ecosystems, climate change (warming and freshening from land run-off) will increase water column stratification which is favorable fo
Background: Levodopa–carbidopa intestinal gel (LCIG) is available in several countries for the treatment of advanced levodopa-responsive Parkinson’s disease (PD) with severe motor fluctuations and dyskinesia when other treatments have not given satisfactory results. Objective: Our objective was to summarize the present evidence base for LCIG therapy through a systematic review of the literature. M
Background: Alzheimer's disease (AD) neuropathology is associated with neuroinflammation, but there are few useful biomarkers. Mutant variants of triggering receptor expressed on myeloid cells 2 (TREM2) have recently been linked to late-onset AD and other neurodegenerative disorders. TREM2, a microglial receptor, is involved in innate immunity. A cleaved fragment, soluble TREM2 (sTREM2), is presen
Objective: The aim of this study was to compare the outcome of immediate versus delayed radical prostatectomy (RP) in men with low-grade prostate cancer. Materials and methods: The study included a nationwide population-based cohort in the National Prostate Cancer Register of Sweden, of 7608 men with clinically localized, biopsy Gleason score 6 prostate cancer who underwent immediate or delayed RP
