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Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at
This work has been done for Tetra Pak Distribution (TPD) at the Department of Engineering Logistic at the Lund Institute of Technology. My task was mainly to create a set of simulation models based on the Tetra Pak Distribution Lines. These models are going to be used by TPD to try to analyse the effect of the accumulation systems on the line efficiency. The inputs for the models are failure rate
Objective . Salivary cortisol is widely used in occupational health research. However, many ordinary daily activities can influence the concentrations of cortisol and the interpretation of field studies. The aim of the present study was to evaluate the effect of lifestyle factors on salivary cortisol in everyday settings. Material and methods . Healthy employees participated in one or more sub-stu
Popular science summary To Migrate or Not to Migrate! An interesting experiment to test how gender, personality traits, size, and condition affect migration in Roach (Rutilus rutilus). Partial migration is a phenomena in which migration does not take place in every individual’s lifecycle. The reason for this type of migration has not yet been totally understood. However, there has been studies
This study examined grammatical features of written Swedish-English code-swtching found in two Swedish web discussion forums. More specifically, this study sought to show that the so-called insertion patter, as defined by Muysken (2000), is the the predominant patter of code-switching found in these two forums. In order to determine the dominant pattern of code-switching found in the two forums, I
The purpose of this thesis was to study the correspondence of occupant load factors determined by the guidance document of Finnish National Building code and the real occupant loads measured from shopping malls. The correspondence of occupant load factors determined according to Finnish National Building Code were compared with the occupant load factors determined in other national and internat
Control theory plays a big part in the development of more efficient and environ- mental friendly combustion engines. But the process of designing good controllers can be very time consuming and complex. One way to reduce the time spent on design and testing of a controller is to use simulations to get fast feedback of the controllers performance. Therefore, in this thesis it is investigated if a
This paper introduces machine learning to automate the coarsening choices in coarsened exact matching (CEM) as a monotonic imbalance bounding matching class. I suggest to replace the otherwise arbitrary multivariate stratification process with a binary classification tree. This way, I can minimise potential bias caused by subjective preferences. By using the LaLonde (1986) dataset, I systematicall
The question of whether the choice of performance measure (PM) matters when evaluating Hedge funds has for a long time been subject to debate . This study explores the same question with a sample of individual monthly data from 669 Hedge Funds over a 10 year period. The standard rank correlation tests usually applied when studying the topic yield weaker correlations between the PM:s in our study t
This master thesis has been development at the Department of Automatic Control in Lund University between October 2003 and February 2004 under the supervision of Karl-Erik Årzen.The topic of this master thesis has been to investigate and implement the code generation for an AVR Mega8 microcontroller from JGrafchart, program development by the Department of Automatic Control.This project concerns t
We analyzed 37 primary invasive carcinomas for BRCA1 and BRCA2 mutations by screening the entire coding regions of both genes. Seven predicted truncating mutations (four in BRCA1 and three in BRCA2) and one novel BRCA1 missense variant (S1542C) were identified (8/37, 22%). Two of the BRCA1 mutations were somatic changes, whereas the remaining three BRCA1 changes and all mutations of BRCA2 were fou
A Saccharomyces cerevisiae screening strain was designed by combining multiple genetic modifications known to improve xylose utilization with the primary objective of enhancing xylose growth and fermentation in xylose isomerase (XI)-expressing strains. Strain TMB 3045 was obtained by expressing the XI gene from Thermus thermophilus in a strain in which the GRE3 gene coding for aldose reductase was
