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Diabetes and obesity have long been known to be related. The recently characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been implicated as a molecular link between impaired glucose tolerance (IGT) and obesity in mice. A search for sequence variants at the human resistin locus identified nine single-nucleotide polymorphisms (SNPs) but no coding variants. An investigation into th

Twelve palaeogeographical reconstructions illustrate environmental changes at the southwest rim of the Scandinavian Ice Sheet 40-15 kyr BP. Synchronised land, sea and glacier configurations are based on the lithostratigraphy of tills and intertill sediments. Dating is provided by optically stimulated luminescence and calibrated accelerator mass spectrometry radiocarbon. An interstadial sequence ca

In this chapter, a detailed review of the current understanding of thephysical processes of droplet breakup in a high-pressure homogenizer (HPH) is presented,covering breakup mechanisms by laminar shear in the gap inlet and its boundarylayers, by local turbulence in the gap exit jet, and by cavitation. Experimentalevidence of the effects of homogenization pressure, Thoma number, dispersed andconti In this chapter, a detailed review of the current understanding of the physical processes of droplet breakup in a high-pressure homogenizer (HPH) is presented, covering breakup mechanisms by laminar shear in the gap inlet and its boundary layers, by local turbulence in the gap exit jet, and by cavitation. Experimental evidence of the effects of homogenization pressure, Thoma number, dispersed and

Importance: Information about how risk for bipolar disorder is transmitted across generations and how parental risk for bipolar disorder relates to their children's risk for schizophrenia and major depression is limited. Objective: To evaluate the sources of parent-offspring transmission of bipolar disorder and its familial cross-generational association with schizophrenia and major depression. De

We present the first reconstruction of the micrometeorite flux to Earth in the Silurian Period. We searched 321 kg of condensed, marine limestone from the Late Silurian Cellon section, southern Austria, for refractory chrome-spinel grains from micrometeorites that fell on the ancient sea floor. A total of 155 extraterrestrial spinel grains (10 grains >63 μm, and 145 in the 32-63 μm fraction) were

OBJECTIVE: To examine how different scoring models for a diet quality index influence associations with mortality outcomes. DESIGN: A study within the Malmö Diet and Cancer cohort. Food and nutrient intakes were estimated using a diet history method. The index included six components: SFA, PUFA, fish and shellfish, fibre, fruit and vegetables, and sucrose. Component scores were assigned using pre

The transport and gain properties of quantum cascade (QC) structures are investigated using a nonequilibrium Green's function (NGF) theory which includes quantum effects beyond a Boltzmann transport description. In the NGF theory, we include interface roughness, impurity, and electron-phonon scattering processes within a self-consistent Born approximation, and electron-electron scattering in a mea

Thesis purpose: The purpose of this thesis is to determine how a technolo-gically enhanced shopping tool, synergizing eCRM tech-niques with personalized promotion at the point-of-sale, can increase customer loyalty by considering perceptions of current grocery retailer loyalty programs in Sweden. Methodology: An exploratory research was undertaken in the light of a qualitative method collecting pr

In the last decade, the European Union (EU) has faced several different security challenges, such as terrorist attacks, military conflicts, and a refugee crisis, threatening the safety of its citizens and interests. This has contributed to the EU's desire to improve its security and defense capacity. As part of the solution, the EU established the European Peace Facility (EPF) in 2021, which p

Uppsatsen utreder plenumbestämmelsens tillämpningsproblem inom straffrätten och hur förutsebarheten för den enskilde påverkas av att plenumbestämmelsen lyser med sin frånvaro. Prejudikaträtten är inte absolut i Sverige. Men detta innebär inte att ändringar av prejudikat ska ske med lätthet, utan en strävan att upprätthålla förutsebarheten för den enskilde är viktig. Med anledning av detta finnerThe essay examines the absence of the application by the Supreme Court of plenary sessions, which is necessary for establishment of precedent in the Swedish legal system, within the penal law and how the predictability in individual cases thus suffers. The precedence principal is not consistently adhered to by the Swedish legal system. This does not suggest that changes of precedent should be ma

Inhibition of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) is under increasing investigation for its therapeutic potential in many diseases. Existing AMPK inhibitors are however limited, with poor selectivity and substantial off-target effects. Here, we provide mechanistic insights and describe the cellular selectivity of the recently identified AMPK inhibitor BAY-3827. A 2.5-Å