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Background: Fibroblast growth factor 23 (FGF23) is the earliest marker of disturbed mineral metabolism as renal function decreases. Its serum levels are associated with mortality in dialysis patients, persons with chronic kidney disease (CKD) and prevalent cardiovascular disease (CVD), and it is associated with atherosclerosis, endothelial dysfunction and left ventricular hypertrophy in the genera
Popular Abstract in Swedish Svår alfa-1antitrypsinbrist (AAT-brist), s.k. PiZZ, är ett ärftligt tillstånd som har en hög förekomst i Sverige, cirka 1/1600. Bristen innebär ökad risk för utveckling av kroniskt obstruktiv lungsjukdom (KOL), speciellt hos rökare. Leversjukdom är också relativt vanlig och kan förekomma såväl i barndomen som i hög ålder. Levercirros (skrumplever) och levercancer är öveSevere alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. The aims of the studies in this thesis which bases on AATD registry are to
Background: In previous meta-analyses, tea consumption has been associated with lower incidence of type 2 diabetes. It is unclear, however, if tea is associated inversely over the entire range of intake. Therefore, we investigated the association between tea consumption and incidence of type 2 diabetes in a European population. Methodology/Principal Findings: The EPIC-InterAct case-cohort study wa
The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext
Following the adoption of the "double carbon" policy in China, the concept of Environmental, Social, and Governance (ESG) has gained considerable attention within the Chinese market, significantly impacting investor decision-making. This thesis examines the impacts of ESG principles on the overall financial performance of investment portfolios. Through the classification of Chinese A-lis
Piratverksamhet är inte speciellt uppmärksammat i västvärlden – media lyfter inte upp det och det är heller inte en speciellt prioriterad punkt på politikernas agenda. Det betyder dock inte att det inte är ett stort problem. Det påverkar många, både känslomässigt och ekonomiskt, på en individnivå men också på en nationell, regional och global nivå. Problemet är komplext och har en lång historia,Piracy is not given very much attention in the western part of the world – there is not many news about it in the medias, and it is not very high prioritized on the politicians’ agenda. However, this does not indicate that it is not a problem. Piracy affects many people, at an individual level as well as at a national, regional and global level. The problem is complex and has long history, not le
The right to development (RTD) is an inalienable human right that has been affirmed by the United Nations General Assembly in the Declaration on the Right to Development (DRD), in 1986. The right has also been reaffirmed by several international declarations and in two regional human rights conventions, the African [Banjul] Charter on Human and Peoples’ Rights and Arab Charter on Human Rights, and
In the central Himalayas, water dynamics are expected to change due to multiple factors like climate change, hydro power development and shifting land use practices. This thesis looks at possible changes in water dynamics in Marsyandi river basin, Nepal, as well as causes to those changes and how they are perceived locally. Grounded in critical physical geography, the study uses mixed methods an
Based on more than thirty years' fieldwork, this book aims to increase the understanding of music played on elaborate wooden floats which form vital components in Japanese festivals with a religious dimension. The focus is on float-festivals in Aichi prefecture in central Japan; but wider perspectives, international as well as national, also come into play.Float-festivals date back several centuriThis book aims to increase the understanding of festival music in Japan. It is based on more than thirty years of fieldwork. Close study of one local festival in the town of Taketoyo is combined with a wider comparative analysis that covers most of the of the Aichi prefecture in central Japan. All these festivals are float-festivals. Charged with spiritual power, the floats serve as mobile shrines
Independent estimation and verification of fossil CO2 emissions on a regional and national scale are crucial for evaluating the fossil CO2 emissions and reductions reported by countries as part of their nationally determined contributions (NDCs). Top-down methods, such as the assimilation of in situ and satellite observations of different tracers (e.g., CO2, CO, Δ14CO2, XCO2), have been increasing
BACKGROUND: Platelet transfusions are frequent in the Intensive Care Unit (ICU), either as prophylaxis against bleeding complications or as treatment for bleeding. The European Society of Intensive Care Medicine guidelines for ICU patients generally recommend not using prophylactic platelet transfusions unless the platelet count falls below 10 × 10 9 cells/L in non-bleeding patients and make no re
This study aimed to obtain high-resolution 3D isotropic turbo spin-echo (TSE) wrist MRI acquisitions at 7T, with and without fat suppression, facilitated by compressed-sensing (CS) acceleration. In 16 healthy subjects, fat-suppressed (FS) and nonfat-suppressed (NFS) TSE wrist images were obtained. The protocol consisted of a SENSE-accelerated scan, with an isotropic voxel size of 0.45 mm and acqui
OBJECTIVES: The efficacy of long-term opioid therapy (LTOT) in treating patients with chronic non-cancer pain (CnCP) is questionable, and the potential risks of adverse effects are well established. The aims were as follows: (1) compare characteristics in patients exposed to LTOT vs non-exposed. (2) Regarding opioid-exposed patients, describe characteristics of patients with risk factors for opioi
Substantial variability exists in what pathologists consider as pT4a in colorectal cancer when tumor cells are within 1 mm of the free peritoneal surface. This study aimed to determine if the measured sub-millimeter distance between tumor cells and the free peritoneal surface would offer an objective means of stratifying patients according to the risk of developing peritoneal metastases. Histologi
BACKGROUND: Lead exposure has been associated with increased incidence of adverse clinical cardiovascular outcomes. Atherosclerosis has been suggested as one of the underlying mechanisms, and findings from experimental studies support this, but human data are scarce. OBJECTIVES: Our objective was to determine the association between environmental lead exposure based on blood lead (B-Pb) concentrat
In contemporary Western theatre and actor’s training, there is a tension between different traditions in the actor’s work, concerning the bodily practices that are related to representation, construction of identities, authenticity and self-expression. One aspect of the actor’s methodical tradition – the openness to suffering and sacrificing oneself in the name of the arts – will be displayed and
This dataset features geocoding for the complete population of:Landskrona at the block-level from 1904-1967;Landskrona at the address-level from 1939-1967; andKävlinge at the block-level from 1939-1967.All these populations are part of the Scanian Economic-Demographic Database (SEDD). SEDD is a high-quality, longitudinal database that covers five Scanian parishes: Halmstad, Hög, Kågeröd, Kävlinge,
