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Streptococcus suis is an important cause of different pathologies in pigs and humans, most importantly fibrinosuppurative meningitis. Tissue infected with this pathogen is substantially infiltrated with neutrophils, but the function of neutrophil extracellular traps (NETs) - a more recently discovered antimicrobial strategy of neutrophils - in host defence against Strep. suis has not been investig
AIMS: The onset of clinical type 1 diabetes (T1D) is preceded by the occurrence of disease-specific autoantibodies. The level of autoantibody titers is known to be associated with progression time from the first emergence of autoantibodies to the onset of clinical symptoms, but detailed analyses of this complex relationship are lacking. We aimed to fill this gap by applying advanced statistical mo
Introduction: The proportion of women who postpone childbearing is increasing. As malignancy risk increases with age, pregnancy in connection with malignancy will become more common. Material and methods: We compared infants born 1994-2011 to women with a malignancy within six months prior to the last menstrual period or during pregnancy with offspring of women without a previous malignancy. Five
This article is contributing to the future of copyright law debate by exploring the recently harmonised originality standard in the EU copyright law and its suitability to a creative sharing community of Wikipedia. It shows that the “free creative choices” and “author’s personal” touch criteria established by the CJEU might be unsuitable not only because of practical concerns, but also because the
Background: Little evidence is available on how public transport features can impact on older people's health. The overarching aim of this paper is to evaluate socio-demographic, health and mobility-related factors correlated with health-related quality of life among people aged between 75 to 90 years old in three Swedish Municipalities. Methods: Within the SEBEM study, a cross-sectional survey us
Renovating the European building stock has for almost two decades been a matter of importance. For Sweden, it is important to renovate its multifamily buildings in order to achieve a reduced energy use, but also because renovation is needed due to building materials and services reaching (or having passed) the end of their life span. In order to renovate properly, renovation measures must be imple
Multilevel Monte Carlo is a novel method for reducing the computational costwhen computing conditional expectations of stochastic processes. This paper considersthe transition density for diffusion processes. It is known that the transitiondensity can be written as an expectation by utilizing the law of total probabilitycombined with the Markov property. This idea is combined with the multilevelMoMultilevel Monte Carlo is a novel method for reducing the computational cost when computing conditional expectations of stochastic processes. This paper considers the transition density for diffusion processes. It is known that the transition density can be written as an expectation by utilizing the law of total probability combined with the Markov property. This idea is combined with the multilev
The light pulses of a mode-locked Ar+ laser have been synchronized to the synchrotron radiation pulses of the SuperACO storage ring in Orsay. In order to test the feasibility and to demonstrate the capability for the investigation of free atoms we have studied the two-photon ionization of atomic Helium and Xenon via the He* 1s3p and Xe* 5p55d resonant state, respectively. The experimental results
Background: Despite smoking and risky alcohol drinking being modifiable risk factors for cancer as well as postoperative complications, perioperative cessation counselling is often ignored. Little is known about how cancer patients experience smoking and alcohol interventions in relation to surgery. Therefore the aim of this study was to explore how bladder cancer patients experience a perioperati
A diesel engine developed for an international market must be able to run on different fuels considering the diesel fuel qualities and the increasing selection of biofuels in the world. This leads to the question of how different fuels perform relative to a standard diesel fuel when not changing the hardware settings. In this study five fuels (Japanese diesel, MK3, EN590 with 10% RME, EN590 with 3
The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional respo
Parasites are expected to exert long-term costs on host fecundity and longevity. Understanding the consequences of heritable polymorphic variation in disease defence in wild populations is essential in order to predict evolutionary responses to changes in disease risk. Telomeres have been found to shorten faster in malaria-diseased individuals compared with healthy ones with negative effects on lo
One of the challenges of establishing an industrially competitive process to ferment lignocellulose to value-added products using Saccharomyces cerevisiae is to get efficient mixed sugar fermentations. Despite successful metabolic engineering strategies, the xylose assimilation rates of recombinant S. cerevisiae remain significantly lower than for the preferred carbon source, glucose. Previously, One of the challenges of establishing an industrially competitive process to ferment lignocellulose to value-added products using Saccharomyces cerevisiae is to get efficient mixed sugar fermentations. Despite successful metabolic engineering strategies, the xylose assimilation rates of recombinant S. cerevisiae remain significantly lower than for the preferred carbon source, glucose. Previously,
In the early 1980s many social theorists claimed that the ‘New Social Movements’ (NSMs) were the authentic social movements of our time. This claim is discussed in relation to two traditions in the analysis of social movements. The ‘American’ tradition focuses on the single-issue movement of a protest and mobilizing character. The ‘European’ tradition focuses on the relation between major societa
The high-spectral-resolution optical studies of the energy gap evolution, supplemented with electronic, magnetic, and structural characterization, show that the modification of the GaAs valence band caused by Mn incorporation occurs already for a very low Mn content, much lower than that required to support ferromagnetic spin-spin coupling in (Ga,Mn)As. Only for n-type (Ga,Mn)As with the Mn conten
We sought to investigate morphological and resting state functional connectivity changes to the striatal nuclei in Parkinson disease (PD) and examine whether changes were associated with measures of clinical function. Striatal nuclei were manually segmented on 3T-T1 weighted MRI scans of 74 PD participants and 27 control subjects, quantitatively analysed for volume, shape and also functional conne
An extremely acid mine soil polluted with Cu was amended with pine bark, crushed mussel shell or a 1:1 mixture of these two by-products. The performance of the soil microbial community was measured as the bacterial and fungal community growth, which were monitored during 2 years following the amendments. Pine bark caused significant increases of microbial growth rates, but with distinct difference
