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Background: Because breast cancer (BC) is molecularly heterogeneous, diagnosis and treatment will likely benefit from comprehensive genetic profiling. However, routine, high-resolution sequencing is not feasible yet, due to implementation challenges associated with whole-genome sequencing of formalin-fixed paraffin embedded (FFPE) BC samples. Therefore, we explored the potential of an alternative
December 20th is marked in the Russian calendar as a day dedicated to the workers of the "security organs". However, these are not just any "organs" that have security in their job description. In this case, the term “security organs” emphasises exclusively the importance of foundation of political police in the emerging Soviet Russia.On December 20, 1917, the Russian Communist Party established i
Artificial intelligence (AI) methods are powerful tools for biological image analysis and processing. High-quality annotated images are key to training and developing new algorithms, but access to such data is often hindered by the lack of standards for sharing datasets. We discuss the barriers to sharing annotated image datasets and suggest specific guidelines to improve the reuse of bioimages an
Elevated air temperature and atmospheric vapor pressure deficit (VPD) are key drivers of plant physiological and ecological processes. However, their relative impacts on vegetation productivity remain difficult to isolate due to the strong coupling between them. This coupling complicates efforts to disentangle independent effects, particularly under compound drought conditions at regional or globa
Objectives: This study aimed to assess the relationship between dietary intake and disease outcomes in patients with radiographic axial spondyloarthritis (r-axSpA), focusing on inflammation and disease activity, while also evaluating other health outcomes, and to compare dietary intake between patients and controls. Method: In a cross-sectional analysis, we studied 295 patients with r-axSpA (modif
In this conceptual article, we propose that legal professionaldecision makers’ transformation of narratives incourt (encoding) influences their emotional attunementto the stories at hand. First, we argue that the processof encoding is linked to the strict demand for dispassionin legal settings. Second, we introduce three techniquesthat regulate the emotional processes at play duringthe encoding ofIn this conceptual article, we propose that legal professional decision makers’ transformation of narratives in court (encoding) influences their emotional attunement to the stories at hand. First, we argue that the process of encoding is linked to the strict demand for dispassion in legal settings. Second, we introduce three techniques that regulate the emotional processes at play during the enco
The European Union (EU) has recently presented several new legal proposals for promoting ecodesign and product labeling. The aim is to harmonize national practices and rules in the EU, to regulate issues like product lifetime and repairability in a more comprehensive way, to introduce new tools like digital product passports, and to introduce labeling schemes for repairability and durability. In p
Increasing drought frequency and intensity affect biophysical functions of natural ecosystems. In tropical semi-arid savannas, while immediate drought effects are well-studied, the drought legacy effects on vegetation composition and associated ecosystem functions remain unclear. We used data of vegetation composition, net ecosystem CO 2 exchange, surface albedo and evapotranspiration (ET) in 201
BackgroundAcute-phase proteins (APPs) reflect systemic inflammation and nutritional status, yet their perioperative trajectories and clinical utility as biomarkers of outcome in advanced ovarian cancer (aEOC) remain unclear. We aimed to characterise perioperative APP fluctuations and assess their associations with postoperative complications.MethodsThis observational study included patients underg
Cathode–solid electrolyte (SE) interfacial stability issues pose a significant challenge to stable and high-power operations of all-solid-state batteries, which promise greater energy density, thermal stability, and safety than the current liquid electrolyte-based Li-ion technology. For technologically important Ni-rich NMCs (LiNixMnyCozO2 or NMCxyz; x/y/z: Ni/Mn/Co stoichiometry) with sulfid
Climate and forest structure are considered major drivers of forest demography and productivity. However, recent evidence suggests that the relationships between climate and tree growth are generally non-stationary (i.e. non-time stable), and it remains uncertain whether the relationships between climate, forest structure, demography and productivity are stationary or are being altered by recent c
The field of organ transplantation is experiencing a transformative shift with the rise of Advanced Therapy Medicinal Products (ATMPs), which include gene therapies, somatic cell therapies, and tissue-engineered products. These therapies offer new, potentially curative treatments for longstanding medical challenges, impacting numerous patients. However, their adoption is hindered by complex regula
Introduction: Out-of-pocket health expenditures (OOPE) are an inefficient and inequitable means of health financing. Identifying the factors driving these expenditures is crucial to design effective prepayment schemes. This study uses Cambodia—a country with high OOPE and prevalent informal employment—as a case study to analyse the relative contributions of healthcare, health, and social factors t
The origin and evolution of sponges have attracted interest, not only because they are among the most basal metazoans, but also because they act as important ecological engineers in the ocean. Previous research suggested that sponge groups diversified quickly during the Cambrian Series 2, while Terreneuvian sponge fossils are conspicuously rare and poorly substantiated. Yet, an increasing number o
This paper introduces a new framework – RoadRAT - to calculate the probability of inundation, wave runup, and storm erosion impacting coastal roads. Extreme value analysis is applied to annual maxima of observed and simulated still water level levels (SWL), total water levels (SWL + runup), and storm erosion volumes. The probability of impact on the road is derived both for the present conditions
In the present work, we describe the design, synthesis, and evaluation of a galectin-8- binding fluorescent probe designed for a competitive fluorescence polarization (FP) assay for screening new galectin-8N inhibitors. The probe was characterized for its photophysical properties and its binding affinity for galectin-8N was determined by using FP. We evaluated the probe in a competitive FP assay w
