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Rituximab is a pioneering anti-CD20 monoclonal antibody that became the first-line drug used in immunotherapy of B-cell malignancies over the last twenty years. Rituximab activates the complement system in vitro, but there is an ongoing debate on the exact role of this effector mechanism in therapeutic effect. Results of both in vitro and in vivo studies are model-dependent and preclude clear clin
This article summarises the current understanding of the heterogeneity of type 1 diabetes from a June 2024 international Expert Forum organised by the editors of Diabetes, Diabetes Care, and Diabetologia. The Forum reviewed key factors contributing to the development and progression of type 1 diabetes and outlined specific, high-priority research questions. Knowledge gaps were identified and, nota
Within the circular economy, alternatives to fast-fashion include second-hand clothing consumption. The narratives surrounding second-hand clothing have shifted from the stigma of old, dirty, smelly clothing to trendy, sustainable, and bargain items. The environmental benefits of second-hand are realised through the increased use-intensity and avoided production of new garments. However, these ben
NB-IoT was designed as an add-on to the LTE standard to enable wide area cellular connectivity to low-cost devices to facilitate the rapid growth of the Internet of Things. NB-IoT was found to increase the idle power consumption of the radio unit in an example LTE radio base station by almost 17%, costing the mobile network operator not only money, but also harming the environment through increase
The combination of a growing global population and a limiting amount of farmland creates a need for new innovative food products to achieve a global sustainable development and a healthy population. Rapeseed press cake is a low-cost by-product of rapeseed oil production and is very high in protein and fiber. The rapeseed protein contains high concentrations of S-amino acids as methionine and cyste
A world leading food processing and packaging company, Tetra Pak works with the vision of ‘Protect what’s good’ and aims to be a pioneer in developing sustainable packaging. Tetra Pak offers a wide range of carton packaging out of which aseptic carton packages are the most common. Aseptic cartons have laminate packaging material with six layers consisting of paperboard, aluminium (Al) and polyethy
Background. Although myocardial infarction (MI) is strongly related to smoking, few have studied why some smokers are more vulnerable than others. This study explored how the risk of MI in current and former smokers is modified by other cardiovascular risk factors. Methods. Incidence of MI (fatal and nonfatal) amongst 10619 women, 48.3 ± 8.2 years old, were studied in relation to smoking, hyperte
Huntington's disease (HD) is a devastating, inherited neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Peripheral symptoms, such as skeletal muscle wasting, progressive weight loss, altered body composition and endocrine disturbances exist alongside neurodegeneration. Both the mutant gene and protein are expressed in cells and tissues throughout the body.Weight l
The growing utilization of second homes has led to extended heating periods and, to some extent, renovations to enhance their standards, resulting in increased energy and resource consumption. This study, conducted in Sweden, investigates user patterns across various seasons, heating systems, and implemented energy renovation measures. Findings reveal that 40% of second homes in winter sport areas
ObjectiveTo evaluate the long-term costs and quality of life (QoL) with and without disease-modifying treatments (DMTs) of patients with multiple sclerosis (MS).MethodsData on resource consumption, productivity losses, QoL (utility), and fatigue were collected from 1355 patients registered with a patient association and descriptive analyses was performed.A Markov model was developed to estimate co
This study addresses the critical need to report original and current findings on the global food system's ability to meet the growing natural resource demands of an estimated 9?billion global population. The objective is to provide guidance for researchers in developing strategies to reduce climate change risks in the food and beverage supply. To achieve this, we propose integrating innovative in
Rapid and continuing advances in biomarker testing are not being matched by uptake in health systems, and this is hampering both patient care and innovation. It also risks costing health systems the opportunity to make their services more efficient and, over time, more economical. The potential that genomics has brought to biomarker testing in diagnosis, prediction and research is being realised,
Several studies have shown that consumers with a high organic consumption often have dietary habits that include more fruit and vegetables but less red meat. This paper takes a novel approach by investigating whether changes in consumption of organics and improvements in dietary habits also are related. The results show that many consumers seem to improve their diet while increasing the organic co
The cardiovascular effects of coffee consumption remain debated, particularly regarding early-stage subclinical atherosclerosis. This study investigated the association between coffee intake, genetic predisposition, and the risk of subclinical coronary and carotid atherosclerosis in 24,835 participants from the Swedish CArdioPulmonary bioImage Study (SCAPIS). Coffee intake was assessed via self-re
Aim: Complement-mediated atypical haemolytic uraemic syndrome (aHUS) is a rare disease with high mortality and morbidity if left untreated. The diagnostic work-up is complicated and the manifestations overlap with other conditions. Therefore, we hypothesize that complement-mediated aHUS is an under diagnosed disease. Methods: A cohort of 768 referrals referred to the Coagulation Unit in Malmo, Swe
Transport Biofuels in Sweden: Joanne Morris Transport Biofuels in Sweden 16 May 2011 1 Transport Biofuels in Sweden: Stakeholders’ perceptions of the Renewable Energy Directive’s governance of the industry by Joanne Morris Supervisor: Sara Brogaard (LUCSUS) Co-supervisor: Bodil Elmqvist (LUCSUS) A Thesis submitted to Lund University in partial fulfillment of the requirements for the degree of MAST
https://www.lumes.lu.se/sites/lumes.lu.se/files/morris_joanne_thesis_2011.pdf - 2026-07-17
Objective. When treatments with the potential to change the natural history of a disease are introduced, their longer-term effect on costs and quality of life (utility) has to be estimated using economic models. However, to remain useful tools, models must be updated when new information becomes available. Our earlier models in rheumatoid arthritis (RA) have been based on functional status, but it
The area of VAT constitutes an area fully harmonized within the EU, and the framework for the European VAT is established in the VAT Directive and is implemented in Sweden through the Swedish VAT Act. The European VAT is a general tax on consumption with the purpose of only taxing purchases for personal consumption. However, the European VAT cover all stages of production and distribution. To achi
Staden Cochabamba kallas för “Bolivias kulinariska huvudstad”. Många kulinariska traditioner och kulturer möts där. Den här avhandlingen handlar om hur den vardagliga matkulturen är en del av reproduktionen av historiska ojämlikheter mellan olika delar av befolkningen, särskild mellan ursprungsbefolkningen och befolkningen som betraktar sig som ”västerländsk”. Avhandlingen utgörs av en inledande dCochabamba city, also referred to as the “gastronomic capital of Bolivia”, is a place where different cultures and tastes meet. Indulging in rich culinary traditions is a part of everyday life, but so are social differentiations reproducing long-standing inequalities between the indigenous and the non-indigenous population. In this thesis, the practices and politics surrounding food are used as a
