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Fast determination of antibiotics in whole blood

There is a need for analytical methods capable of monitoring blood antibiotic levels in real time. Here we present a method for quantifying antibiotic levels in whole blood that does not require any sample pretreatment. The tests employ the enzyme penicillinase to assay for penicillin G, penicillin V and ampicillin using a flow-injected biosensor, the Enzyme Thermistor. Optimal flow rates, sample

Apparent exchange rate mapping with diffusion MRI.

Water exchange through the cell membranes is an important feature of cells and tissues. The rate of exchange is determined by factors such as membrane lipid composition and organization, as well as the type and activity of aquaporins. A method for noninvasively estimating the rate of water exchange would be useful for characterizing pathological conditions, e.g., tumors, multiple sclerosis, and is

Prevalence of Aryl Hydrocarbon Receptor expression in the myeloid cell-line MUTZ-3

De senaste åren har allergisk kontaktdermatit ökat i förekomst och orsakas då av att en individ kommer i kontakt med en substans som denna har utvecklat en allergi emot. Detta leder ofta till att individen får utslag vid kontaktpunkten, men kan i värsta fall få fatala konsekvenser. För att minska skadan denna sjukdom ger, både ur ett ekonomiskt och socialt perspektiv, finns det ett behov att hitta

Nanoscale Structural Characterization of Individual Viral Particles Using Atomic Force Microscope Infrared (AFM-IR) and Tip-Enhanced Raman Spectroscopy (TERS)

Viruses are infections species that infect a large spectrum of living systems. Although displaying a wide variety of shapes and sizes, they are all composed of nucleic acid encapsulated into a protein capsid. After virions enter the host cell, they replicate to produce multiple copies of themselves. They then lyse the host, releasing virions to infect new cells. High proliferation rate of viruses

A combination of parabolic and grid slope interpolation for 2D tissue displacement estimations

Parabolic sub-sample interpolation for 2D block-matching motion estimation is computationally efficient. However, it is well known that the parabolic interpolation gives a biased motion estimate for displacements greater than |y.2| samples (y = 0, 1, …). Grid slope sub-sample interpolation is less biased, but it shows large variability for displacements close to y.0. We therefore propose to combin

Robust smooth segmentation approach for array CGH data analysis

Motivation: Array comparative genomic hybridization (aCGH) provides a genome- wide technique to screen for copy number alteration. The existing segmentation approaches for analyzing aCGH data are based on modeling data as a series of discrete segments with unknown boundaries and unknown heights. Although the biological process of copy number alteration is discrete, in reality a variety of biologic