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Moraxella catarrhalis is a Gram-negative human mucosal commensal and pathogen. It is a common cause of exacerbation in chronic obstructive pulmonary disease (COPD). During the process of infection, host colonization correlates with recognition of host molecular patterns. Importantly, in COPD patients with compromised epithelial integrity the underlying extracellular matrix is exposed and provides
A patient with unresectable periampullary malignancy found at laparotomy has traditionally received a prophylactic double bypass (biliary and duodenal), associated with considerable morbidity. With modern endoscopic treatments, surgical bypass has become questionable. This study aims to compare the two strategies. Sahlgrenska University Hospital (SU) performs a double bypass (DoB) routinely, and S
Effective disaster risk management is a requisite for sustainable development and it is paramount to include a wide range of stakeholders to manage risk in this context. Recent research indicates the significance of making ideas of what is valuable and important to protect explicit in any disaster risk management initiative that involves several stake- holders. The purpose of this article is thus
Alloreactive memory T cells are major barriers to transplantation acceptance due to their capacity to accelerate rejection. Here, we investigated the effects of combined treatment with arsenic trioxide (As(2)O(3)) and blocking monoclonal antibodies (mAb) against CD154 and LFA-1 (anti-CD154/LFA-1) on graft survival as well as changes in pathology and immunological responses in mice with adoptively
Background— Bone morphogenetic proteins (BMPs) are multifunctional proteins that regulate the proliferation, differentiation, and migration of a large variety of cell types. Like other members of the transforming growth factor-ß family, BMPs elicit their cellular effects through activating specific combinations of type I and type II serine/threonine kinase receptors and their downstream effector p
Olf-1/early B-cell factor (O/E-1) is a transcription factor important for B-lymphocyte and neuronal gene regulation. Here we report that all three known O/E genes (O/E-1, -2, and -3) are expressed in mouse adipose tissue and are upregulated during adipocyte differentiation. Forced expression of O/E-1 in either the preadipocyte cell line 3T3-L1 or mouse embryonic fibroblasts augmented adipogenesis,
Cytokines such as interleukin 3 (IL-3), kit ligand (KL), and flt3 ligand (FL) promote survival of hematopoietic stem cells and myeloid progenitor cells. In many cell types, members of the Bcl-2 gene family are major regulators of survival, but the mediating mechanisms are not fully understood. Using two myeloid progenitor cell lines, FDCP-mix and FDC-P1, as well as primary mouse bone marrow progen
Particle emissions from residential wood combustion in small communities in Northern Sweden can sometimes increase the ambient particle concentrations to levels comparable to densely trafficked streets in the center of large cities. The reason for this is the combination of increased need for domestic heating during periods of low temperatures, leading to higher emission rates, and stable meteorol
This paper investigates the nonnative acquisition of German verb placement on the basis of new, quantified, empirical data from Swedish post-puberty learners. Contrary to existing claims in the literature on the acquisition of V2 languages (here, German), there is no evidence for a universal developmental sequence for verb placement. Rather, non-subject-initial V2 transfers from the L1 grammar (he
Aim: Risk factors for vitamin B12 deficiency in infants are not fully understood. The aim of the study was to assess predictors of total homocysteine and methylmalonic acid analysed in newborn screening dried blood spots. Methods: In a Norwegian case control study, we analysed total homocysteine and methylmalonic acid in newborn screening dried blood spots of 86 infants clinically diagnosed with v
Integration of machine learning (ML) components in critical applications introduces novel challenges for software certification and verification. New safety standards and technical guidelines are under development to support the safety of ML-based systems, e.g., ISO 21448 SOTIF for the automotive domain and the Assurance of Machine Learning for use in Autonomous Systems (AMLAS) framework. SOTIF an
Background: Observational data on composite scores often comes with missing component information. When a complete-case (CC) analysis of composite scores is unbiased, preferable approaches of dealing with missing component information should also be unbiased and provide a more precise estimate. We assessed the performance of several methods compared to CC analysis in estimating the means of common
BACKGROUND: Unemployment is high not only among people with mental illness, but also among young adults in general. The combination of having a severe mental illness and being young entails a particularly problematic situation for young people with psychosis. This study aimed to understand how this group envision their future possibilities for entering the labour market or engaging in other produc
This thesis focus on how notions of equality and neo-liberal pursuits for growth are negotiated in policy, discussing the relationship between problem definition at top level and the implemented solution at policy level. The problem is defined in the European Union’s growth strategy Europe 2020 as Europe having to increase productivity, while the implemented solution I focus on is the emerging foc
China has ever since the 1990s emerged as a manufacturing superpower, following its liberalized trade reforms and its entrance to the World Trade Organization. This has caused China to expand their exports substantially, in particular to the OECD countries. This has lead to an increasing debate on whether, or to what extent, increasing manufacturing exports from China to the OECD countries has con
Purpose Hodgkin lymphoma (HL) survivors are at an increased risk of stroke because of carotid artery irradiation. However, for early-stage HL involved node radiation therapy (INRT) reduces the volume of normal tissue exposed to high doses. Here, we evaluate 3-dimensional conformal radiation therapy (3D-CRT), volumetric-modulated arc therapy (VMAT), and proton therapy (PT) delivered as INRT along w
Introduction This study aimed to evaluate the clinical impact of implementing routine emergency computed tomography (eCT) for all patients presenting with suspected acute renal colic at the emergency department (ED). Material and methods We did a retrospective observational study of all patients who underwent eCT for suspected acute renal colic at the ED in Helsingborg between May 9, 2023 and May
The purpose of this thesis is to develop knowledge about visual information seeking and how it might be affected by socio-technical circumstances, with its focus on GeoGuessr players’ research through Google Street View. The study asks two research questions: 1. How do GeoGuessr players use Google Street View to do research? and 2. How can Google Street View’s socio-technical circumstances affect
