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Serotonin, a highly pro-inflammatory molecule released by activated platelets, is formed by tryptophan. Tryptophan is also needed in the production of kynurenine, a process mediated by the type I interferon (IFN)-regulated rate-limiting enzyme indoleamine 2,3-dioxygenase (IDO). The aim of this study was to investigate levels of serotonin in patients with the autoimmune disease systemic lupus eryth
Females of the Indian meal moth, Plodia interpunctella, and females of the Mediterranean flour month, Ephestia kuehniella (both Lepidoptera: Pyralidae), exhibit daily rhythms in calling behavior. The peak in P. interpunctella calling occurs at dusk, whereas E. kuehniella calls preferentially at dawn. This behavior turned arrhythmic in P. interpunctella females in constant darkness (DD) and remaine
Injury to the brain (e.g., stroke) results in a disruption of neuronal connectivity and loss of fundamental sensori-motor functions. The subsequent recovery of certain functions involves structural rearrangements in areas adjacent to the infarct. This remodeling of the injured brain requires trafficking of macromolecular components including cholesterol and phospholipids, a transport carried out b
Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves candidates for causality, but simply act as markers for functional variants. By means of imputation
Computational modeling is a commonly used method to understand, predict and explain for instance the organization of neuronal connectivity. Here it is applied to the problem of the development of the neural control of locomotion. Locomotion, e.g. walking and swimming, can be characterized as an alternate activation of opposing muscles and is controlled by central pattern generators, CPGs, in the s
This research study is based on the problematisation of criminal gangs’ development within Swedish society and its presence towards young Swedish individuals. Furthermore, the study was built on investigating changes that take place within legislations. This study’s research problem and purpose was designed to investigate whether mitigating circumstances within the Swedish Penal Code can result in
The overarching aim of this study is to gain understanding on what major state-centric international relations-theory could best explain certain aspects on modern inter-state maritime disputes. From neorealist and neoliberalist schools of thought an operational schematic was formed as a theoretical ram to break down and explain underlying structures in instances of the empirical data-universe, whi
The purpose of the study is to quantitatively verify the systematic property of default risk and to statistically test if adding a default risk factor to the Fama and French Three-Factor Model can enhance its performance. The applied method is derived from the Fama and French Three- factor methodology and enhancing it with an additional default risk factor. The study employs Credit-Default Swap sp
Previous studies have found what is referred to as a dilution effect of nondiagnostic information when subjects make evaluative judgment tasks of future performance, meaning that the presence of nondiagnostic information makes predictions less extreme. However, a large study recently failed to replicate this effect. The hypothesis of this study is that judges can discard from obviously irrelevant
Kruppel-like factor 11 is a pancreatic transcription factor whose activity induces the insulin gene. A common glutamine-to-arginine change at codon 62 (Q62R) in its gene KLF11 has been recently associated with type 2 diabetes in two independent samples. Q62R and two other rare missense variants (A347S and T220M) were also shown to affect the function of KLF11 in vitro, and insulin levels were lowe
During 1956 through 1987, 96,891 children have been screened for neonatal hip instability according to the tests of Ortolani and Barlow. In 1956 through 1972 only 4/58, 759 (0.07 permille) were missed, whereas during 1980 through 1987, 12/19, 398 (0.6 permille) were missed. This increase is not caused by any formal alteration of the screening programme. The screening has prevented a late diagnosis
A single intradermal injection of the mineral oil pristane in susceptible DA.1F rats induces erosive arthritis closely mimicking rheumatoid arthritis (RA). Pristane-induced arthritis (PIA) is driven by autoreactive T cells but no autoantigen has been identified to date. We therefore analyzed B and T cell responses to autoantigens potentially involved in the pathogenesis of RA, including IgG, citru
This paper is arguing that China’s political and economic opening in 1978, also referred to as China’s open door policy, was initiated by a change within China’s institutions affecting the political as well as the economic system. Since the opening in 1978 up until today (2012), constant economic reforms and developments as well as political progress can be observed. Domestic examples of China’s p
OBJECTIVES: Esophageal pH monitoring using a wireless pH capsule has been suggested to generate less adverse symptoms resulting in improved patient acceptance compared with the catheter-based method although evidence to support this assumption is lacking. The aim of this study was to evaluate and compare the subjective experience of patients undergoing both techniques for esophageal pH monitoring.
