Filetype
Neuroblastoma is an embryonal tumour of the peripheral sympathetic nervous system (SNS). One of the master regulator genes for peripheral SNS differentiation, the homeobox transcription factor PHOX2B, is mutated in familiar and sporadic neuroblastomas. Here we report that inducible expression of PHOX2B in the neuroblastoma cell line SJNB-8 down-regulates MSX1, a homeobox gene important for embryon
OBJECTIVE AND STUDY DESIGN: We report for the first time an inhibitory effect on cell division and germ tube formation by Candida albicans and strains of other Candida species by putrescine and cadaverine. RESULTS: Both bacterial amines showed a dose-dependent inhibition of germ tube formation by C albicans, as well as budding (inhibition of cell division) of strains of other Candida species (ie,
The MAM (meprin/A5-protein/PTPmu) domain is present in numerous proteins with diverse functions. PTPmu belongs to the MAM-containing subclass of protein-tyrosine phosphatases (PTP) able to promote cell-to-cell adhesion. Here we provide experimental evidence that the MAM domain is a homophilic binding site of PTPmu. We demonstrate that the MAM domain forms oligomers in solution and binds to the PTP
In the concluding chapter, the editors take stock of the state of integration seventy years after the EU’s inception. In the early 2020s, the EU faces once again the fateful question of whether integration should proceed in a federal direction, or whether varied flexible solutions to concrete problems should guide its development instead. The stock-taking is seen against the acute challenges that
There is a major contradiction between the current model of international elite sport and efforts to mitigate climate change. This study investigates climate action delay discourses within the sports sector by analyzing 28 semi-structured interviews with athletes and sports federation employees. Based on the two climate delay discourse typologies of Lamb et al. (2020, Global Sustainability, 3: e17
Vi möter dagligen larmrapporter om att den regelbaserade världsordning som etablerades efter andra världskriget håller på att bryta samman. För den som vill få en förklaring till varför detta händer och en hum om vart världen är på väg finns en färsk analys att tillgå i Eswar Prasads The Doom Loop, i svensk översättning ungefär ”domedagsspiralen”.
Plastic’s unique properties are vital for a sustainable future, but its excessive global use signifies consumer society’s wastefulness, often found in short-lived products. Plastic development has overlooked recycling needs, resulting in low material recycling due to a wide array of plastic types with varying additives, leading to recycling challenges. Research focused on thermoplastics aims to re
Many preterm infants are exposed to multiple transfusion types during their admission in the neonatal intensive care unit. Yet, evidence supporting current practice consists of several randomized controlled trials and observational studies focusing on a single transfusion product at the time. Rather than approaching transfusions as three distinct categories as currently done in the literature, the
MILJÖVETENSKAP Preliminärt schema datum 2018-12-10 Kurs: MVEB15 Miljöpolitik och förvaltning Kursansvarig: Åsa Knaggård Lärare: Elias Isaksson (EI), Åsa Knaggård (ÅK), Tobias Nielsen (TN), Maja Tejre (MT) Lokaler: Mossen Öster, Ekologihuset Litteratur: Carter, Neil (2018). The politics of the environment. Ideas, activism, policy . Tredje upplagan. Cambridge: Cambridge University Press. Dahlström,
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/prel_schema_mveb15_vt2019.pdf - 2026-06-30
Burkitt's lymphomas harbour chromosomal translocations bringing c-MYC into the vicinity of one of the immunoglobulin gene loci. Point mutations have been described within c-MYC in several Burkitt's lymphomas and it has been proposed that translocation into the Ig loci might have transformed c-MYC into a substrate for the antibody hypermutation mechanism. Here we test this hypothesis by exploiting
The Carbon Border Adjustment Mechanism, introduced by Regulation (EU) 2023/956 of the European Parliament and of the Council of 10 May 2023 establishing a carbon border adjustment mechanism (hereinafter ‘CBAM’), represents one of the major steps of the European Union (hereinafter ‘EU’) to combat carbon leakage. Since CBAM is currently in its transitional phase till December 31, 2025, the implicati
The study of clines, or geographical variations of a given trait, can help understand how the interactions of genetics and local environments determine phenotypic diversity. The marine snail Littorina saxatilis (Olivi, 1792) exhibits a gradual change in the relative frequencies of shell color morphs across populations in the estuary system of the Rias Baixas (Galicia, NW Iberian Peninsula). A cons
This research analyzes the political engagement of Turkish citizens on Twitter, in which underrepresented groups and individuals search for democratic public space to mobilize against injustice. With this in mind, the study focuses on the civic engagement of Turkish citizens on Twitter with the hashtag #istanbulsözleşmesiyaşatır, which translates to‘istanbulconventionsaveslives’. The hashtag is a
Asbestos mining and production manufacturing infringes on the right to live free from toxic pollution. Though as this right is not yet formally codified, this thesis will make a case for its recognition and concurrently push for a global ban of this fibrous set of naturally occurring minerals that are extremely hazardous to the human body. Highlighting the grave harms of asbestos as a benchmark th
For preventing economic double taxation and neutralization of choice between direct and indirect investments, states might grant domestic funds certain tax advantages while not extending it to non-residents, which possibly result in international double taxation. This issue arises mostly because of the different features of the investment funds. Such as their legal form, tax treatment, regulatory
Purpose The thesis examines the use of Big Data Analytics by audit firms. The purpose of the study is to establish the impact of this new audit technology in practice. Three research questions are developed. The first question investigates how BDA is impacting the audit process. The second research question analyses how the use of BDA is affecting the application of professional judgement by audit
