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Nervous system function relies on the establishment of complex gene expression programs that provide neuron-type-specific and core pan-neuronal features. These complementary regulatory paradigms are controlled by terminal selector and parallel-acting transcription factors (TFs), respectively. Here, we identify the nuclear factor Y (NF-Y) TF as a pervasive direct and indirect regulator of both neur
Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated wit
Multiconfigurational pair-density functional theory (MC-PDFT) is a promising way to describe both strong and dynamic correlations in an inexpensive way. The functionals in MC-PDFT are often “translated” from standard spin density functionals. However, these translated functionals can in principle lead to “translated spin densities” with a nonzero imaginary component. Current developments so far ne
Bladder cancer is a fast-moving and recurrent malignancy where survival hinges on early detection and precise risk stratification. The search for robust biomarkers is urgent, and CD44v6 has emerged as a compelling candidate. In this study, we explored the clinical and functional associations of CD44v6 expression in bladder cancer. Integrated analyses of patient samples and cell lines showed that h
This study is an effort to find a connection between the high number of people on sick leave, the occupational health situation at the workplace, and stronger market competition and globalisation forces. The basis for the study is statistics, mainly on injuries and diseases, interviews with people in different positions with either long experience within the safety and health situation or otherwi
In recent decades, with the advancement of technologies facilitating reproduction, parents have been able to make decisions regarding their childrens’ reproductive potential: to preserve their fertility when threatened by genetic conditions or medical treatment; to use their gametes or embryos to make grandchildren; or even to collect their gametes posthumously and then use them to make grandchild
Variation in the structure and size of the eye in relation to light environments is well-documented across animal taxa. However, the long-term effects of ultraviolet radiation (UVR) on eye size across generations remain understudied, despite natural fluctuations in UVR being common in aquatic habitats. Here, we used Daphnia magna to test whether an evolutionary history of UVR threat modifies plast
Cupriavidus is a bacterial genus related to Burkholderia, with members that can be negative or positive for us. Some species can give people serious, and even deadly diseases. Among the species positive for us is one that can be used for replacing plastic production from fossil oil by a more sustainable method.
Objective: Progressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration with inadequate effectiveness of medications used so far. We now investigated effects of iron on microglia and used the previously identified neuroprotective antipsychotic clozapine in vitro and in chronic experimenta
The objective of this article is to review guidelines that address counselling in the context of genetic testing in order to summarise what aspects of counselling they consider most important, and to examine how they construct the ideal of genetic counselling. Guidelines were collected by examining the websites of different international professional, political, ethical and patient organisations,
BACKGROUND: [Corrected] Clinical assessment is not always sufficient to predict postoperative (PO) cardiac complications. B-type natriuretic peptide (BNP) has an important prognostic value in patients with heart failure. Its value as a predictor of events in orthopedic surgeries has not yet been tested.OBJECTIVE: To assess the value of BNP in predicting cardiac complications in the PO period of or
Type 2 diabetes (T2D) is characterized by insulin resistance and impaired insulin secretion, but the mechanisms underlying insulin secretion failure are not completely understood. Here, we show that a set of co-expressed genes, which is enriched for genes with islet-selective open chromatin, is associated with T2D. These genes are perturbed in T2D and have a similar expression pattern to that of d
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of
Aims: To assess the agreement between the Ross treadmill method and the Åstrand ergometer cycle method, and the repeatability of each method. Methodology: Twenty healthy people aged 22.5 ± 2.2 years were tested on two different days, each day with both methods with a pause of 30 min between the tests. The tests were executed in the reverse order the following test day. Major findings: There was no
The sequence of the N-terminal end of the deduced ctaC gene product of Bacillus species has the features of a bacterial lipoprotein. CtaC is the subunit II of cytochrome caa3, which is a cytochrome c oxidase. Using Bacillus subtilis mutants blocked in lipoprotein synthesis, we show that CtaC is a lipoprotein and that synthesis of the membrane-bound protein and covalent binding of heme to the cytoc
The neuropeptide pituitary adenylate cyclase-activating peptide (PACAP) is expressed in sensory neurons. Expression of several neuropeptides is up-regulated in sensory neurons following inflammation. To examine whether also PACAP expression is regulated by inflammation, PACAP expression in L5 dorsal root ganglion (DRG) was determined, using in situ hybridization, after unilateral adjuvant-induced
Endothelial dysfunction and haemostatic imbalance are believed to be important aetiological factors in the development of acute coronary syndromes. Thrombomodulin (TM) is an integral membrane protein crucial for normal endothelial function and activation of the protein C anticoagulant pathway. We have investigated the importance of a common C/T dimorphism in the TM gene (nucleotide 1418) for devel
Aim This study investigated the effects of skin-to-skin contact on breastfeeding attainment, duration and infant growth in preterm infants, as this has not been sufficiently explored. Methods A prospective longitudinal study on Kangaroo mother care was carried out, comprising 104 infants with a gestational age of 28 + 0 to 33 + 6 and followed up to one year of corrected age. Parents and staff reco
