Filetype
Many lines of evidence suggest that the Parkinson’s disease (PD)-related protein α-synuclein (α-SYN) can propagate from cell to cell in a prion-like manner. However, the cellular mechanisms behind the spreading remain elusive. Here, we show that human astrocytes derived from embryonic stem cells actively transfer aggregated α-SYN to nearby astrocytes via direct contact and tunneling nanotubes (TNT
The aim of this study is to evaluate a new pedagogic approach implemented in a compulsory materials course for product design students at bachelors level at ABC University. When developing a new curriculum for the material course, a decision was made to teach materials and production methods in a contextualized setting with emphasis on how students can deal with materials in a design process. Meth
Background: Pain from various locations in the body and mental illness are common and the comorbidity between the two is well-known although the temporal relationship remains to be determined. Our aim was to follow patients over time to study if pain (here dorsalgia/abdominal pain) or fibromyalgia lead to an increased risk of developing mental illness (here depression/anxiety) and/or the reverse,
The Paris Agreement seemingly reaffirmed the central place occupied by the regime established by the UNFCCC in the international governance of climate change.Although the UNFCCC can be viewed as a form of ‘monocentric’ governance, it has become increasingly clear that the UNFCCC operates as part of a polycentric governance system. Due to the physical and socio-economic interconnections between cli
Purpose: The knowledge about young adults who have lost a parent to cancer is limited, and to reach a broader understanding about this group, this study used the Dual Process Model of Coping with Bereavement (Stroebe and Schut, 1999) as a theoretical framework. The purpose of this study was to describe loss- and restoration-oriented bereavement stressors and psychosocial wellbeing of young adults
Nursing homes are often places where older persons “come to die.” Despite this, death and dying are seldom articulated or talked about. The aim of this study was to explore assistant nurses’ experiences of conversations about death and dying with nursing home residents. This study is part of an implementation project through a knowledge-based educational intervention based on palliative care princ
To meet complex needs in persons and families within specialist palliative care, care team members are expected to work together in performing a comprehensive assessment of patient needs. Team type (how integrated team members work) and team maturity (group development) have been identified as components in team effectiveness and productivity. The aim of the study reported in this paper was to ide
Using Deterministic Lateral Displacement (DLD), we are able to separate bacteria by their size and their chain length. This separation enables the study of these properties as factors of virulence.
The objective of this chapter is to contribute to the understanding of the growth of this global data-driven market ecology, mainly in order to pinpoint important regulatory challenges, where individual choice and agency, as well as competition, seem undermined. Truly, this development holds many promises for new innovation, some more disruptive than others, but also poses challenges that in this
There is an urgent need to start generating energy within cities in order to pave the way for a more sustainable and resilient society. Renewable energy by means of active solar energy systems (solar thermal, ST and/or photovoltaics, PV) can be generated using roofs and facades of buildings. In this study, the annual solar energy potential of typical Swedish city blocks was analysed in order to de
Contamination or damage to X-ray optics is becoming increasingly problematic for beamlines at 3rd and 4th generation storage-rings and FEL sources. Carbon contamination, induced by ultra-intense photon-beams, can cause a major loss in flux, focusing power, and specific absorptions which are detrimental to spectroscopy. For new light sources, with higher coherence, intensity, and repetition rates,
The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2 - dc251198.pdf The Contribution of BMI to a Young Child’s Risk of Islet Autoimmunity Is Dependent on HLA-DR4-DQ8 Without HLA-DR3-DQ2 Jaakko J. Koskenniemi, Joanna L. Clasen, Lu You, Hemang M. Parikh, Kendra Vehik, Jimin Yang, Ulla Uusitalo, Riitta Veijola, Michael J. Haller, Anette
Aims. Chronotropic incompetence and impaired heart rate (HR) recovery are related to mortality. Guidelines lack specific reference values for HR recovery. We defined normal values and studied blunted HR response and recovery and mortality risk. Methods and results. We included 9917 subjects (45% females) aged 18–85 years who performed a cycle exercise test. We defined normal values for peak HR, HR
The age-specific incidence of traumatic brain injury in older adults is rising in high-income countries, mainly due to an increase in the incidence of falls. The severity of traumatic brain injury in older adults can be underestimated because of a delay in the development of mass effect and symptoms of intracranial haemorrhage. Management and rehabilitation in older adults must consider comorbidit
In Art, Science and the Politics of Knowledge, Hannah Star Rogers challenges the traditional dichotomy between art and science, arguing that they share common approaches to knowledge-making. Drawing on Science and Technology Studies and using compelling examples, Star Rogers illuminates the overlapping characteristics – such as emphases on visualisation, enquiry and experimentation – of the two kn
