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A translocation between chromosomes 9 and 22 produces the fusion gene BCR-ABL that leads to the constitutive activity of a tyrosine kinase. This initiates the uncontrolled proliferation of myeloid cells causing Chronic Myeloid Leukaemia (CML). The disorder is treated by tyrosine kinase inhibitors (TKIs) that prevent the progression of CML into more advanced phases. The treatment must be sustained
The case company under study has conducted a continuous process of business model innovation for sustainability since 2007, but is suffering from barriers present in the process. The limited amount of literature on business model innovation for sustainability provides little guidance on barriers. Therefore, this research aims to contribute to the literature by identifying what barriers are present
This thesis explores the European Commission’s proposal on General Reverse Charge Mechanism. VAT is a final tax on consumption. It is imposed on every transaction in the supply chain with the general aim of being deductible and thus being neutral for businesses with the right to deduct. The initial aim of the VAT system was to operate as if all the transactions occurred in one single country; howe
The purpose of this study is to explore the opportunities and challenges for self-employed artists who use social media for their business. The research is focused on painters and illustrators who have digitalised and commercialised their own artwork. The method follows a qualitative research framework with a comparative design of multiple cases on the level of individual artists. Seven artists fr
Purpose: The purpose of this study was two-fold. First, we aimed to develop a framework concerning how to directly and indirectly control discrimination in the workplace using Man- agement Control Systems (MCS). Second, we wanted to examine whether this framework is practically applicable in multinational enterprises (MNE). Methodology: The first part of the purpose was achieved through conduc
The invention of the integrated circuit is a key milestone in the history of electronic circuits. Since its introduction the number of components on a chip have increased rapidly, making them more powerful and able to perform complex operations, but it has also changed the design process. Today different parts of a chip can be developed separately as Intellectual Property (IP) and then put togethe
Urbanisation is an inevitable part of globalisation. With the globalised food chain in place to feed the growing number of people living in urban areas. A remedy is often expressed to be urban farming, with local, sustainable production of food. This study presents a preliminary assessment of the dynamics between urban farms and residents in Malmö. Urban farms produce available food for the reside
En del av det fenomen som kallas skattebaserodering och vinstförflyttning (BEPS) händer när multinationella koncerner flyttar vinster med hjälp av räntebetalningar och ränteavdrag. Sverige har försökt angripa problemet genom att introducera regler som begränsar ränteavdrag i sin nationella lagstiftning. Genom antagande av den Europeiska Unionens (EU) första Skatteflyktsdirektiv (ATAD 1) så har detA part of the phenomenon known as tax base erosion and profit shifting (BEPS) occurs when multinational entities (MNEs) shift profits through the aid of interest payments and interest deductions. Sweden has attempted to address this issue through introducing rules limiting interest deductions in national legislation. Through the adoption of the first Anti-Tax Avoidance directive (the ATAD 1) by th
Public procurement and the purchasing of goods, services and works comprises about 14% of the European gross domestic product (GDP). Procurement initiatives, guidance and tools therefore can have significant influence to leverage demands for more sustainable and circular products and services. This study explores the current circular public procurement (CPP) landscape, looking at barriers and oppo
Uppsatsen är baserad på två hovrättsdomar angående internetavstängningar i Indien med en systematisk innehållsanalys av rättsliga yttranden och en teori om yttrandefrihet i informationssamhället. Syftet med studien är att förstå resonemangen från domarna kring implementeringen av lagarna, både i de två utvalda domsluten och domarnas tolkning av yttrandefriheten och rätten till personlig frihet. De
Credit activity is essential for financial institutions, acting as the primary means banks deploy resources and generate revenue. As a key indicator of financial distress, corporate default has severe repercussions on investors, creditors, regulators, and policymakers. Credit risk embodies the uncertainty banks confront prior to lending, accounting for the partial or complete non-recovery of loan
The establishment of Indonesian AID can be seen as Indonesia’s official statement to the world on its intent of playing a more prominent role as a donor of international development aid. However, looking at the available data, it seems that Indonesian AID is still deep in the early days of its establishment. Little seems to have gone into “enforcing” its role as donor, with “reorganizing” seeming
Collecting enough labeled images to train an artificial neural network (ANN) is a common struggle since the process is tedious, time consuming and expensive. CellaVision, a company that creates analyzers that automate the process of finding and pre-classifying abnormal blood cells using machine learning, runs into this problem regularly. When new generations of analyzers are being produced, the im
The purpose of this study is to explore what organisational capabilities are needed to monetise on the value of a digital transaction platform during a business model transformation. The study brings forward six capabilities which are divided into the three themes: enable, create and capture. To enable value on the platform, the capabilities innovative mindset and supportive leadership are assumed
Att bygga material av proteiner är en konst som våra kroppar är specialister på. Men när vi medvetet försöker designa proteinmaterial, så blir det tydligt hur komplexa och svårstyrda biofysikens lagar är. Det här examensarbetet har som mål att lägga grunden för ett proteinmaterial som kan skapas eller dissociera som respons på förändrad Ca2+-koncentration. Om ett sådant material kan framställas me
Execution time is an important issue in the field of numerical analysis. Simulations are getting more and more complex and the execution times are rapidly increasing. In the scope of this thesis a time integration library is used to solve initial value problems. The aim of the thesis is to implement and investigate two different approaches to decrease the execution time for the library. The main f
During evolution the human brain has increased drastically in size compared to that of other primates. However, little is known about primate brain development as it is difficult to study human and primate brains in the laboratory due to the scarcity of tissues. Yet, it is essential to study primate brains and understand the molecular features leading to the human brain’s unique cognitive function
By the end of the 1960s there was a growing environmental concern all around the globe. As a part of an answer to this challenge the need was recognized for a reorientation of the education processes towards developing knowledge, attitudes and skills for resolving the issues. This was the birth of the concept of Environmental Education (EE). However, this notion is far from being static as it went
