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Organizations may be confronted with both expected and unexpected events that challenge their abilities to provide these services uninterrupted. Traditional strategies based on anticipation and planning are primarily useful for expected events, but for unexpected events, organizations must develop capacities to adapt to situations and conditions not foreseen. As systems and societies are becoming
In the software industry, the drive to add new features often overshadows the need to improve existing code. Large Language Models (LLMs) offer a new approach to improving codebases at an unprecedented scale through AI-assisted refactoring. However, LLMs come with inherent risks such as braking changes and the introduction of security vulnerabilities. We advocate for encapsulating the interaction
Pixel sensors in 3D technology equip the outer ends of the staves of the Insertable B Layer (IBL), the innermost layer of the ATLAS Pixel Detector, which was installed before the start of LHC Run 2 in 2015. 3D pixel sensors are expected to exhibit more tolerance to radiation damage and are the technology of choice for the innermost layer in the ATLAS tracker upgrade for the HL-LHC programme. While
A magainin derivative, designated MSI-344, was produced in Escherichia coli as fusion protein, by utilizing a truncated amidophsphoribosyltransferase of E. coli as a fusion partner. Bacterial cells transformed with the gene encoding the fusion protein were grown to a high cell density and induced with isopropyl-1-thio-b-D-galatoside (IPTG) to initiate product expression. The fusion protein was
Imbalances in dopamine activity significantly contribute to the pathophysiology of several neuropsychiatric disorders, including addiction, ADHD, schizophrenia, impulse control disorders, and Parkinson's Disease. Neuro(active)steroids, comprising endogenous steroids that finely modulate neuronal activity, are considered crucial regulators of brain function and behavior, with implications in variou
There is increasing recognition of the role that artificial intelligence (AI) systems can play in managing health crises. One such approach, which allows for analysing the potential consequences of different policy interventions is agent-based social simulations (ABSS). Here, the actions and interactions of autonomous agents are modelled to generate virtual societies that can serve as a “testbed”
IntroductionAbout two thirds of in-hospital deaths following successful resuscitation aftercardiac arrest are due to hypoxic-ischaemic brain injury. (1,2) Most occur after adecision to withdraw from life sustaining therapy (WLST) in patients wheremeaningful neurological recovery is unlikely. (2) In 2021 the EuropeanResuscitation Council (ERC) and the European Society of Intensive Care Medicine(ESI
ALADDIN is a proposed fixed-target experiment at the LHC for the direct measurement of charm baryon dipole moments. The detector features a spectrometer and a Cherenkov detector, while the experimental technique is based on the phenomena of particle channelling and spin precession in bent crystals. TWOCRYST, a proof-of-principle test at the LHC for the proposed experiment, is planned during the LH
The short-time iterative adaptive approach is a spectral estimation alternative to the short-time Fourier transform for non-stationary vibration analysis. This technique offers a reduction in leakage effects and a higher resolution in exchange for a higher computational complexity. The short-time iterative adaptive approach can be summarized as a high-resolution data-dependent approach which has b
This article is about finding the limit set for banded Toeplitz matrices. Our main result is a new approach to approximate the limit set Λ(b), where b is the symbol of the banded Toeplitz matrix. The new approach is geometrical and based on the formula Λ(b) = ∩ρ∊(0, ∞) sp T (bρ), where ρ is a scaling factor, i.e., bρ(t):= b(ρt), and sp(∙) denotes the spectrum. We show that the full intersection ca
Despite the widely recognized potential of product-as-a-service (PaaS) business models to contribute to the circular economy, many industrial case studies have reported that several systemic factors tend to hinder product manufacturers from effectively designing such solutions. More specifically, factors such as linear value chains, organizational structures, and market and financial conditions te
The impacts of climate change may be particularly severe for geographically isolated populations, which must adjust through plastic responses or evolve. Here, we study an endangered Arctic plant, Primula nutans ssp. finmarchica, confined to Fennoscandian seashores and showing indications of maladaptation to warming climate. We evaluate the potential of these populations to evolve to facilitate sur
IntroductionResearch evidence suggests that radiographers often rely on previous training, traditional practices, work experience and protocols developed within the department rather than up-to-date research-based evidence in their daily practice. The aim of the study was to investigate factors that might impact the development of evidence-based practice amongst radiographers in clinical public se
Cytidine triphosphate synthetase (CTPS) is a key enzyme in nucleic acid and phospholipid biosynthesis and its activity is increased in certain human cancers, making it a promising drug target. The crystal structure of the synthetase domain of human CTPS, which represents the first structure of a CTPS from an eukaryote, has been determined. The structure is homotetrameric and each active site is fo
To address environmental and climate issues, alternative technologies to fossil resources are sought after, both for the production of fuels and of chemicals. Algae appear as an attractive solution and have applications in the food, feed, energy or chemistry at large. A study funded by ADEME and conducted by ENEA, a consulting firm for energy and sustainable development for the industrial sector,
Solar-driven photocatalytic green hydrogen (H2) evolution reaction presents a promising route toward solar-to-chemical fuel conversion. However, its efficiency has been hindered by the desynchronization of fast photogenerated charge carriers and slow surface reaction kinetics. This work introduces a paradigm shift in photocatalyst design by focusing on the synchronization of charge transport and s
Welcome to the fifth edition of the REWBAH workshop, a satellite event of the IEEE International Requirements Engineering Conference (RE). The REWBAH workshop fosters discussion related to requirements engineering resulting from the need to build software systems that not only support healthcare, but also promote well-being, encourage patients and the population in general to live according to hea
Universities are expected to play a proactive role in the sustainable development andtransformation of their regions. However, they face external and internal barriers toplay that role. One possible approach to overcome those barriers is through trans-formative academic institutions (TAIs). TAIs are defined as research centres createdwithin universities to proactively engage in territorial develop
This paper presents a methodology to fully characterize the dynamic range of a linear X-ray detector, usually employed to perform radiography and tomography. The proposed procedure analyzes each pixel of the detector and presents the results both in terms of general performance of the detector and as a spatial distribution of different parameters for each pixel. This method has been applied to thr
