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Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 × 10(-20)) near CXCR5
Plant canopies affect the canopy micrometeorology, and thereby alter canopy exchange processes. For the simulation of these exchange processes on a regional or global scale, large-scale vegetation models often assume homogeneous environmental conditions within the canopy. In this study, we address the importance of vertical variations in light, temperature, CO2 concentration and humidity within th
beta-1,4-Gatactosyltransferase 7 (beta 4GalT7) is an essential enzyme in the biosynthesis of glycosaminoglycan (GAG) chains of proteoglycans (PGs). Mammalian cells produce PGs, which are involved in biological processes such as cell growth and differentiation. The PGs consist of a core protein, with one or several GAG chains attached. Both the structure of the PGs and the GAG chains, and the expre
This work introduces a novel analytical method for the detection and study of GAD65 autoantibodies, which have been implicated in the onset of type 1 diabetes. There is a clinical need for a rapid and automated assay for GAD65 autoantibodies. Therefore, this method was designed to exploit the advantages of bead injection (BI) analysis for enzyme-linked immunosorbent assays (ELISA). BI ELISA is a m
Modelling the sedimentation of suspensions with partial differential equations requires constitutive relations (material properties) to be known. Restricted to suspensions obeying Kynch's assumption (ideal suspensions), this paper deals with the inverse problem, which is to estimate the batch-settling flux function from experimental data. A new batch-settling test is suggested, from which it is th
This research tests whether self-labelling with a derogatory or reclaimed label is perceived as an act of reclamation. A pilot study (N = 102) identified English terms used to label lesbian women and gay men. The main study (N = 276) used a between-groups vignette design in which participants read about a woman/man self-labelling with a descriptive (lesbian/gay), reclaimed (queer), or derogatory g
Deep learning has allowed for remarkable progress in many medical scenarios. Deep learning prediction models often require 105–107 examples. It is currently unknown whether deep learning can also enhance predictions of symptoms post-stroke in real-world samples of stroke patients that are often several magnitudes smaller. Such stroke outcome predictions however could be particularly instrumental i
Aviation is a highly inter-connected system. This means that a problem in one area may cause effects in other countries or parts of the Air Transport System (ATS). Examples range from local air traffic disruptions to the 2010 volcanic ash crisis. Agility, like resilience, refers to the ability to cope with dynamics and complexity in a flexible manner, by adjusting and adapting performance and the
This paper presents a search for a new Z′ vector gauge boson with the ATLAS experiment at the Large Hadron Collider using pp collision data collected at s = 13 TeV, corresponding to an integrated luminosity of 139 fb −1. The new gauge boson Z′ is predicted by Lμ − Lτ models to address observed phenomena that can not be explained by the Standard Model. The search examines the four-muon (4μ) final s
What difference can local participation make in a world where inequality increases everywhere, where segregation pulls communities apart and where policymakers marginalise the needs and interests of the people whose lives their decisions affect the most? This question was central two decades ago when research on participatory institutions took off. Leftist scholars described participatory budgetinWhat difference can local participation make in a world where inequality increases everywhere, where segregation pulls communities apart and where policymakers marginalise the needs and interests of the people whose lives their decisions affect the most? This question was central two decades ago when research on participatory institutions took off. Leftist scholars described participatory budgetin
The microbial use of resources to sustain life and reproduce influences for example, decomposition and plant nutrient provisioning. The study of “limiting factors” has shed light on the interaction between plants and their environment. Here, we investigated whether carbon (C), nitrogen (N), or phosphorus (P) was limiting for soil microorganisms in a subarctic tundra heath, and how changes in resou
Extremely large filled-aperture ground-based optical-IR telescopes, or ELTs, ranging from 20 to 100m in diameter, are now being proposed. The all-important choice of the aperture must clearly be driven by the potential science offered. We here highlight science goals from the Leiden Workshop in May 2001 suggesting that for certain critical observations the largest possible aperture - assumed to be
Objective: The European System for Cardiac Operative Risk Evaluation (EuroSCORE) is used to identify patients at high risk for aortic valve replacement (AVR) in whom alternative procedures, such as trans-catheter aortic valve implantation (TAVI), may be appropriate. The aim of the present study was to calibrate and validate the EuroSCORE for different cardiac surgery procedures to improve patient
The estimation of dynamic panel data models with interactive effects and moving average errors is considered. This is accomplished by making an extension to the factor analytical (FA) estimator which was originally designed for dynamic panels with fixed effects only and serially uncorrelated errors. The results show that the additional allowances have no effect on the asymptotic properties of the
Almost 30 years have passed since the dismantling of South Africa’s apartheid system, putting an end to the long history of racial segregation, discrimination, and oppression. But has it really changed? This research highlights the emergence of Black Economic Empowerment (BEE) as an affirmative policy instrument to advance land reform and rectify the enduring inequalities in the country’s agricult
