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Single cell gene expression assays have become a powerful tool with which to dissect heterogeneous populations. While methods and software exist to interrogate such data, what has been lacking is a unified solution combining analysis and visualisation which is also accessible and intuitive for use by non-bioinformaticians, as well as bioinformaticians.
This thesis started with a desire to delve into the impact that natural disasters have on small communities in an Australian context, how climate change exacerbates their effect, and the role that design can play in mitigating the impact on people and the natural environment. Initial research into bushfires, drought, floods, and heat landed this project in Western Sydney, in an area not far from w
Glycan utilization plays a key role in modulating the composition of the gut microbiota, but molecular insight into oligosaccharide uptake by this microbial community is lacking. Arabinoxylo-oligosaccharides (AXOS) are abundant in the diet, and are selectively fermented by probiotic bifidobacteria in the colon. Here we show how selectivity for AXOS uptake is established by the probiotic strain Bif
We update the forcings for the PMIP3 experiments for the Last Millennium to include new assessments of historical land use changes and discuss new suggestions for calibrating solar activity proxies to total solar irradiance.
A reduced finite element model for determining the maximum principal stress of a glass pane subjected to dynamic impact load is developed and compared to a full dynamic finite element model. The reduced model is based on the Rayleigh-Ritz method. The Ritz vectors used are determined by simple static load-cases. The model is applicable to centrically and eccentrically applied impact and to glass of
Acquired hemophilia A (AHA) is an autoimmune disease caused by an autoantibody to factor VIII. Patients are at risk of severe and fatal hemorrhage until the inhibitor is eradicated, and guidelines recommend immunosuppression as soon as the diagnosis has been made. The optimal immunosuppressive regimen is unclear; therefore, data from 331 patients entered into the prospective EACH2 registry were an
Abstract in UndeterminedPurpose - The purpose of this paper is to describe and analyse ways of organizing integrated care for older persons in Sweden during the past decade. Design/methodology/approach - The data consist of 62 cases of development work, described in official reports. A meta-analysis of cases was performed, including content analysis of each case. A theoretical framework comprising
Parkinson’s disease (PD) is a highly heterogenous disorder characterized by bradykinesia, rigidity, rest tremor and non-motor symptoms like cognitive impairment, anosmia, and sleep disturbance. The underlying pathological hallmarks of PD are the degeneration of dopaminergic pigmented neurons in the substantia nigra pars compacta, neuroinflammation and, alpha synuclein inclusions accumulating into
This master thesis has investigated if flow cytometry can be used to monitor bathing water quality on the beaches in Southern Sweden. The current method for monitoring the bathing water quality takes 3 days to get results about the concentrations of fecal indicator bacteria, E.coli and intestinal enterococci, and to get answers if the water is usable or unusable for swimming. These bacteria serve
The goal of this article is to propose, through the use of GIS software, an interdisciplinary method to suggest new touristic flows after the Covid-19 pandemic. Specifically, the aim is to identify those sites of cultural and landscape interest that are little known but with great artistic, cultural, historical and environmental value that could give new vigour to the tourism sector. In the first
Myths, religious beliefs, and symbols are crucial components of ethnicity. PKK as a nationalist separatist armed organization- intensively uses them to construct a Kurdish identity which is compatible with its ideology as well as its objectives to mobilize Kurds and to galvanize their support. This thesis seeks to describe how PKK –as a militant organization- has instrumentalised Islamic related t
Light dark matter is a hypothesized form of dark matter in the 1 MeV to 1 GeV mass range. The Light Dark Matter eXperiment (LDMX) is an upcoming experiment to test the existence of light dark matter, by colliding an electron beam with a tungsten target and assembling a set of events that potentially indicate the existence of light dark matter. The three main detector components of the LDMX are a s
Generally credited to have originated in 2005, coworking spaces provide hybrid work environments to individual professionals, entrepreneurs, and start-ups. Simultaneously, social entrepreneurship has received increasing attention as a solution to topical problems. This thesis aims to provide an empirical exploration of the ways in which coworking spaces facilitate social entrepreneurship, seen fro
The participation of grassroots communities became a must of development projects. International organizations advocate for the inclusion of community members to ensure projects’ success and sustainability. However, community engagement is often undermined by existing power dynamics between implementing agencies and communities. Power imbalances result from the lack of interdependency between acto
The purpose of this study is to investigate the effect of ESG ratings on firm’s credit ratings for real estate investment trusts in the USA. Through a quantitative research methodology, a panel data regression analysis is used in order to examine the effect of ESG rating on firms’ credit ratings. The sample used in our study consists of a set of unbalanced panel data consisting of 3,470 firm-month
Sweden has set a goal to produce 100% renewable electricity in 2040. In order to accomplish this, a transition towards renewable energy (RE) is necessary. However, the development of RE needs to coexist with other interests of the nation, as RE typically occupies large areas of land or off shore water. This has resulted in conflicts, for instance, between offshore wind power development and nation
