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GWAS in people of Middle Eastern descent reveals a locus protective of kidney function-a cross-sectional study

BACKGROUND: Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest immigrant groups in Europe today. Despite poor glucose regulation and high risk for early-onset insulin-deficient type 2 diabetes, they have better kidney function and lower rates

Protein and amino acid intakes in relation to prostate cancer risk and mortality—A prospective study in the European Prospective Investigation into Cancer and Nutrition

Background: The association between protein intake and prostate cancer risk remains unclear. Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid int

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi

Parallel motion vision pathways in the brain of a tropical bee

Spatial orientation is a prerequisite for most behaviors. In insects, the underlying neural computations take place in the central complex (CX), the brain’s navigational center. In this region different streams of sensory information converge to enable context-dependent navigational decisions. Accordingly, a variety of CX input neurons deliver information about different navigation-relevant cues.

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and m

Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

Electro-mechanically switchable hydrocarbons based on [8]annulenes

Pure hydrocarbons with shape and conjugation properties that can be switched by external stimuli is an intriguing prospect in the design of new responsive materials and single-molecule electronics. Here, we develop an oligomeric [8]annulene-based material that combines a remarkably efficient topological switching upon redox changes with structural simplicity, stability, and straightforward synthes

Nowcasting (Short-Term Forecasting) of COVID-19 Hospitalizations Using Syndromic Healthcare Data, Sweden, 2020

We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in Östergötland County (population ≈465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time la

User value and usability of a web-based mindfulness intervention for families living with mental health problems

Mental health problems affect the patients and their families, who may also need therapeutic interventions. Mindfulness interventions have shown beneficial health effects for clinical and healthy populations. A web-based mindfulness intervention was tailored to address families' needs of support and tested in a pilot intervention study. The aim of this study was to explore the participants' experi

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re

Animal migration in the Anthropocene : threats and mitigation options

Animal migration has fascinated scientists and the public alike for centuries, yet migratory animals are facing diverse threats that could lead to their demise. The Anthropocene is characterised by the reality that humans are the dominant force on Earth, having manifold negative effects on biodiversity and ecosystem function. Considerable research focus has been given to assessing anthropogenic im

Hundvänlig : Utmaningar, metoder och affärsmöjligheter för besöksnäringen

Denna rapport analyserar framväxten av hundvänlig turism i Sverige och belyser dess betydelse för besöksnäringens utveckling. Studien visar att hunden i allt högre grad betraktas som en familjemedlem, vilket påverkar resenärers beteenden, val av destination och konsumtionsmönster. Hundägare utgör en reseaktiv och kommersiellt attraktiv målgrupp som främst reser inom Sverige och efterfrågar naturbaThis report analyses the emergence of dog-friendly tourism in Sweden and highlights its significance for the hospitality industry's development. The study shows that dogs are increasingly regarded as family members, influencing travellers’ behaviour, destination choices, and consumption patterns. Dog owners represent a travel-active and commercially attractive target group that primarily travels d

Nuclease-NTPase antiphage defence systems use conserved molecular features to control bacterial immunity

Bacteria encode diverse defence systems, including restriction-modification and CRISPR-Cas, that cleave nucleic acid to protect against phage infection. Bioinformatic analyses demonstrate that many recently identified antiphage defence operons comprise a nuclease and NTPase protein, suggesting that additional nucleic acid-targeting systems remain to be understood. Here we develop large-scale compa

Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape

Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HD ON) state, a relaxed catalytically inactive (HD OFF/SYNTH OFF) state, and an elongated synthesis-competent (SYNTH ON) state, whereas RelA samples only the latter two. The distribution of these states is controlled by starved ribosomes

Oberg 2011 being interdisciplinary

Being Interdisciplinary 12 Being i nterdisciplinary When I started to write this book, I called it “ The Beginners Guide to Interdisciplinary Studies ” . 1 But calling it a guidebook suggests that it is possible to guide the newcomer through the territory. The crux of interdis- ciplinary work is that you enter an unknown territory that requires a protean sensibility. Rather than a compilation of g

https://www.cec.lu.se/sites/cec.lu.se/files/oberg_2011_being_interdisciplinary.pdf - 2026-05-28

Web version diversity in education e5 media

Microsoft Word - Diversity in Education E5 Media.docx Lund university ISBN 978-91-87357-20-6 9 78 91 87 35 72 06 Printed by M edia-Tryck, Lund U niversity 2015 n a o k o to jo a n d B er n a d et t k iss D iversity in E ducation C rossing cultural, disciplinary and professional divides 2017 Diversity in Education Crossing cultural, disciplinary and professional divides edited By naoko tojo and Ber

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/web_version_diversity_in_education_e5_media.pdf - 2026-05-28

Protokoll bs 170925 final

Microsoft Word - protokoll BS 170925 final.docx Bib l io t ek s sty r el s en Närvarande Ledamöter Olov Sterner dekanus, naturvetenskapliga fakulteten, ordförande Gudrun Edgren professor, medicinska fakulteten Christofer Edling professor, samhällsvetenskapliga fakulteten Anders Ljungar-Chapelon professor, konstnärliga fakulteten Jan-Åke Nilsson professor, naturvetenskapliga fakulteten Erik Swietli

https://www.lub.lu.se/internt/sites/lub.lu.se.internt/files/protokoll_bs_170925_final.pdf - 2026-05-28

Talockaite elena

Lund University International Master's Programme in Environmental Science (LUMES) Lithuania's Energy System: Towards SustainabiJity Master Thesis Author: Elena Talockaite Vilnius Gediminas Technical University, Environment Protection Department, Sauletekio al. 11, LT-2040 Vilnius, Lithuania Phone: + 3702 765298 Fax: + 3702 700497 E-mail: vtuaak@ap. vtu.lt Lund, 1998 Acknowledgements First of all,

https://www.lumes.lu.se/sites/lumes.lu.se/files/talockaite_elena.pdf - 2026-05-28