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Mutations in the PORCN gene were first identified in Goltz-Gorlin syndrome patients in 2007. Since then, several reports have been published describing a large variety of genetic defects resulting in the Goltz-Gorlin syndrome, and mutations or deletions were also reported in angioma serpiginosum, the pentalogy of Cantrell and Limb-Body Wall Complex. Here we present a review of the published mutati

In this article we define a new concept that has not previously been theorized: non-Muslim Islam. We argue that theories and methodologies within Islamic studies produce a hierarchy between Muslim and non-Muslim productions of Islam, prioritizing the first. However, this article highlights that Islam may be produced for other purposes than belief in a deity; Islam may for example be important in p

Chronic and acute lung diseases are the third and fourth leading causes of global mortality. Distal lung tissue is severely damaged in many lung diseases, causing respiratory insufficiency from loss of surface area available for gas exchange. Current therapies aim at relieving symptoms and are unable to reverse disease. Lung transplantation remains the only potential curative option at end-stage d

This chapter is an attempt to engage Gilles Deleuze and Félix Guattari’s A Thousand Plateaus, which remains one of the most influential works in contemporary geographical theory through a fictional or apocryphal addition that was not, but perhaps could have been a part of an early draft of their seminal work. The chapter develops the different risks of becoming-animal, -imperceptible, etcetera in

A search for the fully reconstructed Bs0→ μ+μ−γ decay is performed at the LHCb experiment using proton-proton collisions at s = 13 TeV corresponding to an integrated luminosity of 5.4 fb−1. No significant signal is found and upper limits on the branching fraction in intervals of the dimuon mass are set (Formula presented.) at 95% confidence level. Additionally, upper limits are set on the branchin

The invention relates to a bioreactor comprising a tank (100) capable of being operated for a working period, said tank (100) being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms, a light source (200) arranged to emit incident light having a chosen incoming light intensity (Iin) in the direction of the tank, a temperature probe (400) for measuri

BACKGROUND: Knee osteoarthritis (OA) is a major public health issue causing chronic pain, impaired physical function, and reduced quality of life. As there is no cure, self-management of symptoms via exercise is recommended by all current international clinical guidelines. This review updates one published in 2015.OBJECTIVES: We aimed to assess the effects of land-based exercise for people with kn

The lasso is a popular method to induce shrinkage and sparsity in the solution vector (coefficients) of regression problems, particularly when there are many predictors relative to the number of observations. Solving the lasso in this high-dimensional setting can, however, be computationally demanding. Fortunately, this demand can be alleviated via the use of screening rules that discard predictor

A process for enzymatic synthesis of oligosaccharides starting from lower building stones down to monomers, characterized by performing reverse hydrolysis in the presence of a glycosidase by carrying out the reaction in a solution having a high substrate content, i.e. a low water content.

Computer supported gaming is an accepted methodology for the training of decision makers on several levels in crisis management. Commonly these tools are focused on two levels of training. One of them is training managers and leaders as if they had to do everything themselves, like training a general as a tank driver or a gunner, or a politician taking care of a car fire. The other level is aimed

Porous media can be characterized by studying the kinetics of liquid rise within the pore spaces. Although porous media generally have a complex structure, they can be modeled as a single, vertical capillary or as an assembly of such capillaries. The main difficulties lie in separately estimating the effective mean radius of the capillaries and the contact angle between the liquid and the pore. In

Kernel density estimation is an important tool in visualizing posterior densities from Markov chain Monte Carlo output. It is well known that when smooth transition densities exist, the asymptotic properties of the estimator agree with those for independent data. In this paper, we show that because of the rejection step of the Metropolis-Hastings algorithm, this is no longer true and the asymptoti

In this work, we study a flow restoration based network design problem where we assume the knowledge of possible failure situations. We use the idea of a situation disjoint path pair (nominal path, backup path) which are constructed in such a way that at least one of them is operational in any given failure situation for a flow. We present an approximate linear programming formulation of the probl

We have previously identified tagSNPs at 8q24.21 influencing glioma risk. We have sought to fine-map the location of the functional basis of this association using data from four genome-wide association studies, comprising a total of 4147 glioma cases and 7435 controls. To improve marker density across the 700 kb region, we imputed genotypes using 1000 Genomes Project data and high-coverage sequen

A celebrated theorem in operator theory is A. Beurling's description of the invariant subspaces in $H^2$ in terms of inner functions [Acta Math. {\bf81} (1949), 239--255; MR0027954 (10,381e)]. To do the same thing for the Bergman space $L^2_a$ has been deemed virtually impossible by many analysts, in view of the fact that the lattice of invariant subspaces is so large, and that the invariant subsp

The Advanced Resource Connector (ARC) or the NorduGrid middleware is an open source software solution enabling production quality computational and data Grids, with special emphasis on scalability, stability, reliability and performance. Since its first release in May 2002, the middleware is deployed and being used in production environments. This paper aims to present the future development direc