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The impact of islet neuronal nitric oxide synthase (nNOS) on glucose-stimulated insulin secretion (GSIS) is less understood. We investigated this issue by performing simultaneous measurements of the activity of nNOS versus inducible NOS (iNOS) in GSIS using isolated murine islets. Additionally, the significance of extracellular NO on GSIS was studied. Islets incubated at basal glucose showed modes
This study is designed to evaluate the treatment effect of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) (PHBHHx) and human mesenchymal stem cells (hMSC) on axonal regeneration in experimental rat sciatic nerve damage, and compare the results of this modality with autologous nerve grafting. In Spraque-Dawley albino rats, 10-mm-long experimental nerve gaps were created. Three groups were constitute
ObjectivesPatient perceived benefit of treatment for cleft lip and/or palate is of great importance since it is central to development of cleft care. CLEFT-Q is a cleft-specific questionnaire on health-related quality of life. Test-retest reliability, aspects of responsiveness and interpretability are yet to be established for CLEFT-Q. This study aims to investigate these psychometric characterist
Background: Hexavalent chromium (Cr(VI)) is a lung cancer carcinogen. However, the genotoxic and mutagenic effects of Cr(VI) in humans at low-to-moderate occupational exposure levels are unknown. This study aims to investigate the relationship between occupational exposure to Cr(VI) and the presence of oxidative damage, genetic and epigenetic alterations. Methods: We included 113 Cr(VI) exposed wo
New methods and theoretical approaches to the study ofSamizdat - self-publishing and autonomous circulation of textsin the Soviet Union - have been challenging the traditionalviews that portray it as a mere form of dissident activity.Recently, a study by Historian Ann Komaromi classified it as anextra Gutenberg culture, distinct from “print culture” becauseit lacks its characteristics of standardi
Extraordinary finds from the Store Frigård cremation cemetery on the Danish island of Bornholm suggest that the society that used the site played a key role in supra-regional contacts and in the distribution of goods and people across the Baltic Sea between the Continent and Southern Scandinavia during the Iron Age.
AIM: Factors associated with unexpected absence or presence of coronary atherosclerosis in individuals at high/low estimated cardiovascular (CV) risk are largely unexplored. We assessed two extreme phenotypes: 1) no coronary atherosclerosis despite very high CV risk; and 2) severe-extensive coronary atherosclerosis despite low CV risk.METHODS: A multicenter, cross-sectional nationwide, population-
Phylogenetic relationships of the predominantly Andean species-rich nymphalid genus Perisama are explored based on five genetic markers and a total of 3719 bps, and morphological characters of the adults with an emphasis on male genitalia and wing colour patterns. Its monophyly is recovered by including the genera Orophila, which turns out polyphyletic, and Mesotaenia. Two main, highly supported c
Oxidative stress and alterations in redox signalling have been implicated in the pathophysiology of myocardial infarction (MI). NADPH oxidase (Nox) is an important source of reactive oxygen species (ROS) in the infarcted myocardium. Alarmin S100A8/A9 amplifies acute myocardial inflammation in MI and has been shown to be a promising therapeutic target to improve cardiac function post-MI. We aimed t
Emerging evidence from diverse populations highlights the therapeutic benefits of the Crohn’s Disease Exclusion Diet (CDED) in managing Crohn’s Disease. To improve the efficacy of the CDED, there is a need to focus on cultural adaptation and individualization to support dietary adherence to this advanced nutritional therapy. This paper provides a theoretical framework for modifying the CDED to ali
Theoretical calculations show that both the deformation and the pair field change considerably with increasing spin in the ground-state band of transitional rare-earth nuclei with neutron number close to 90. As a consequence of these changes the g factor is expected to show a significant spin dependence in the ground band of certain transitional nuclei. It is suggested that g-factor measurements m
This article is based on a questionnaire study of the media habits of Swedish youth aged 17–18. It examines the time they spend on using fictional texts through various media forms as well as in relation to mode (production/consumption), context (spare time/school), and gender (male/female). It further analyses these media habits and, using media ecology theory, discusses their effects on the lear
The observation of the electroweak production of a W boson and a photon in association with two jets, using pp collision data at the Large Hadron Collider at a centre of mass energy of s=13 TeV, is reported. The data were recorded by the ATLAS experiment from 2015 to 2018 and correspond to an integrated luminosity of 140 fb-1. This process is sensitive to the quartic gauge boson couplings via the
Background and objective: There are multiple pharmacological treatment options for motor symptoms of Parkinson’s disease (PD). These comprise multiple drug classes which are approved for the condition, including levodopa, dopamine agonists, COMT inhibitors, MAO-B inhibitors, NMDA-receptor antagonists, anticholinergics, and others. Some of the drugs are approved for monotherapy and combination ther
Objective: Quality measures in healthcare are crucial for improving outcomes and ensuring patient safety. This study investigated the evolution, implementation, and impact of Primary Care Quality (PCQ). The PCQ aims to facilitate nationwide quality benchmarking, serving as a tool for quality improvement (QI) and research. Design/Settings: A descriptive design outlining the development and operatio
INTRODUCTION: Ulnar nerve entrapment (UNE) is a common disorder with many associated risk factors. Diabetes mellitus (DM) is an established risk factor, but less is known about metabolic risk factors in individuals without diabetes. Our study aimed to explore the association of body mass index (BMI) with UNE during long-term follow-up.METHOD: The population-based cohort study Malmö Diet and Cancer
Volcanic eruptions can have severe societal and environmental impacts as shown by ash dispersal and sulphur emissions from recent Icelandic eruptions. However, ice-core sulphur records demonstrate that these events were minor as compared to eruptions of much larger magnitude in recent centuries, with severe implications for past society documented in historical records. Biological and chemical evi
Codependency is a term used to describe a range of behaviors among persons who are affected by the problematic drug use of family members. This article analyzes how 32 Swedish parents of adult children with drug problems talked about and understood codependency. The sociology of trouble was used as a theoretical framework and three significant themes were identified in the interviews. The parents
Could an even larger push for women empowerment be a viable development strategy for developing countries? A large literature relates the bargaining power of women to improved health and education of their children (Majlesi, 2015; Qian, 2008; Bobonis, 2009; Duflo, 2003; Lundberg, Pollak and Wales, 1997). However, it remains a challenge to find a good proxy for bargaining power that truly reflects
