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cyclicCHAD is a peptide representing the α2β1 integrin binding sequence of the matrix protein chondroadherin (CHAD), which in our hands proved effective at counteracting bone loss in ovariectomised mice by inhibiting osteoclastogenesis. Given that bone metastases are characterised by exacerbated osteoclast activity as well, we tested this therapy in mice intracardiacally injected with the osteotro

Obesity is a global problem and in aspects of lethal ethanol intoxications virtually unexplored. The cause of death in ethanol intoxication is generally considered to be suppression of the respiratory function. Previous research indicates that respiratory function is more vulnerable in obese subjects than in those of normal weight. We hypothesized that lethal blood alcohol concentration (BAC) is l

A recently published genome wide association study identified 29 single nucleotide polymorphisms (SNPs) influencing blood pressure (BP). Case-control studies suggest that a genetic risk score (GRS) based on these 29 SNPs affect the risk of cardiovascular disease (CVD), but its role for CVD at population level is unknown. Here, we prospectively evaluate the impact of this polygenetic BP component o

Background and aims: The positive and negative health effects of dietary carbohydrates are of interest to both researchers and consumers. Methods: International experts on carbohydrate research held a scientific summit in Stresa, Italy, in June 2013 to discuss controversies surrounding the utility of the glycemic index (GI), glycemic load (GL) and glycemic response (GR). Results: The outcome was a

Migraine is a painful disorder with a huge impact on individual and public health. We hypothesize that migraine pain originates from a central mechanism that results secondarily in hypersensitivity in peripheral afferents associated with the cerebral and cranial blood vessels. It has previously been shown that application of inflammatory or algesic substances onto the dura mater or chemical stimul

The Archean Fiskenaesset Complex, SW Greenland, consists of an association of ca. 550-meter-thick layered anorthosite, leucogabbro, gabbro, and ultramafic rocks (peridotite, pyroxenite, dunite, hornblendite). The complex was intruded by tonalite, trondhjemite, and granodiorite (TTG) sheets (now orthogneisses) during thrusting that was followed by several phases of isoclinal folding. The trace elem

The effect of strong intermolecular hydrogen bonding on torsional degrees of freedom is investigated by far-infrared absorption spectroscopy for different methanol dimer isotopologues isolated in supersonic jet expansions or embedded in inert neon matrices at low temperatures. For the vacuum-isolated and Ne-embedded methanol dimer, the hydrogen bond OH librational mode of the donor subunit is fina

Research into innovativeness and customer orientation in the service industry is burgeoning, yet our understanding of the antecedents and consequences of both activities in hospitality management remain unclear. To address this problem we investigate the link between corporate culture, indicators of innovativeness and business performance in the Swiss hotel industry, because the Swiss have a procl

BackgroundStandard treatment of adult Burkitt lymphoma is not defined due to the lack of randomised trials. In this situation, population-based data may represent a useful contribution in order to identify an optimal treatment strategy.Patients and methodsThe aims of this study were to investigate the outcome for adult HIV-negative BL with different chemotherapy regimens, and to assess possible im

Multiple studies have established the superior diagnostic accuracy of video capsule endoscopy (VCE) for the diagnosis of small bowel (SB) Crohn's disease (CD). However, data on the clinical impact of VCE in patients with established CD are scarce. The aim of this study was to examine the impact and safety of VCE on the clinical management of patients with established CD.

Young people create differentiated models of belonging. Their strategies reflect contexualized competences - the capacity to understand and negotiate the influence of national frameworks in specific situations. Theories that understand belonging as processual and intersectional offer useful frameworks with which to analyse this. This article uses data from empirical research with young people in a

We present studies of W and Z bosons with associated high energy photons produced in pp collisions at root s = 7 TeV. The analysis uses 35 pb(-1) of data collected by the ATLAS experiment in 2010. The event selection requires W and Z bosons decaying into high pT leptons (electrons or muons) and a photon with E-T > 15 GeV separated from the lepton(s) by a distance Delta R(l, gamma) > 0.7 in eta-phi

The adsorption of histatin 5 to hydrophilic silica surfaces is governed by electrostatic attractive forces between the positive protein and the negative surface. Hence pH and ionic strength control the adsorbed amount, which can be described by coarse-grained Monte Carlo simulations accounting for electrostatic forces and charge regulation of the protein.

Bridging the gap between understanding work-as-imagined and work-as-done in the perioperative work context represents an important aim of cognitive systems engineering research. Researching this context using a joint cognitive systems theoretical approach can reveal patterns of adaptation that have important implications for system design. Traditional research approaches by non-domain investigator

The essay estimates the relation between population size and municipal costs. Whether the efficiency in service provision in municipalities is depending on population size is discussed in Sweden as well as other countries. The relation is measured using two measures for total costs and two measures for “fixed costs” associated with having an additional decision level. The result give some support

The paper investigates the relationship between population changes and public spending. The main interest is hereby whether local governments can adjust their public spending in times of population decline. A Swedish case study is conducted on all 290 municipalities in regard to their comprehensive school expenses between 2005 and 2013. The theoretical framework incorporates economies of scale and

The Philippines is an island nation in South East Asia consisting of more than 7 000 separate islands. The Philippines is the country in the world that is most often struck by tropical storm; every year between 6 and 9 typhoons hit land in the Philippines. In November 2013 the super typhoon Haiyan hit the nation, killing 10 000 people and causing massive destruction to parts of the infrastructure

This thesis investigates the perceptions of people within the education sector in Lund Municipality regarding sustainability implications of the use of information and communications technology (ICT) in schools. It demonstrates how local perceptions are largely affected by powerful global neoliberal forces. The study is based on a critical discourse analysis of policy documents and interviews with