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The role of caveolae in stretch- vs. flow-induced vascular responses was investigated using caveolin-1 deficient (KO) mice. Portal veins were stretched longitudinally for 5 min (acute) or 72 h (organ culture). Basal ERK1/2 and Akt phosphorylation were increased in organ-cultured KO veins, as were protein synthesis and vessel wall cross-section. Stretch stimulated acute phosphorylation of ERK1/2 an
The anesthetic conserving device (ACD) reduces consumption of volatile anesthetic drug by a conserving medium adsorbing exhaled drug during expiration and releasing it during inspiration. Elevated arterial CO2 tension (PaCO2) has been observed in patients using the ACD, despite tidal volume increase to compensate for larger apparatus dead space. In a test lung using room temperature dry gas, this
In most parts of preindustrial Europe, road transport was a crucial part of rural life as it linked the agricultural producers with urban markets. This study focuses on the development of road transport during the agricultural transformation in order to understand its importance in agricultural change. Scania, in southern Sweden, provides the possibility of examining the basic patterns in the road
Viruses can be described as biological objects composed mainly of two parts: a stiff protein shell called a capsid, and a core inside the capsid containing the nucleic acid and liquid. In many double-stranded DNA bacterial viruses (aka phage), the volume ratio between the liquid and the encapsidated DNA is approximately 1:1. Due to the dominant DNA hydration force, water strongly mediates the inte
Small soluble oligomers, as well as dimers in particular, of the amyloid β-peptide (Aβ) are believed to play an important pathological role in Alzheimer's disease. Here, we investigate the spontaneous dimerization of Aβ42, with 42 residues, by implicit solvent all-atom Monte Carlo simulations, for the wild-type peptide and the mutants F20E, E22G and E22G/I31E. The observed dimers of these variants
An ultrastructural study of the intestine of Derocheilocaris typica revealed an organization of the midgut musculature, which is unique in the Crustacea. This species unusual anal skeletomusculature has also not been seen before. The intestinal musculature of D. typica displays different patterns in the fore-, mid-, and hindgut. Around the foregut, eight pairs of dilator muscles complement a conti
Genetic anomalies on the JNK pathway confer susceptibility to autism spectrum disorders, schizophrenia, and intellectual disability. The mechanism whereby a gain or loss of function in JNK signaling predisposes to these prevalent dendrite disorders, with associated motor dysfunction, remains unclear. Here we find that JNK1 regulates the dendritic field of L2/3 and L5 pyramidal neurons of the mouse
Conclusion: PET-CT scans seem to be sufficient to rule out residual tumour at the primary site. Patients with positive or equivocal PET findings should be scheduled for endoscopy with biopsy or a second PET-CT scan. Objectives: Assessment of remission at the primary site, in patients treated with organ preservation therapy with curative intent, is important to identify residual tumours requiring t
A sizable fraction of testicular germ cell tumour (TGCT) risk is expected to be explained by heritable factors. Recent genome-wide association studies (GWAS) have successfully identified a number of common SNPs associated with TGCT. It is however, unclear how much common variation there is left to be accounted for by other, yet to be identified, common SNPs and what contribution common genetic var
This article considers the challenges faced by digital evidence specialists when collaborating with other specialists and agencies in other jurisdictions when investigating cyber crime. The opportunities, operational environment and modus operandi of a cyber criminal are considered, with a view to developing the skills and procedural support that investigators might usefully consider in order to r
Excited states in the T-z = -1 nucleus V-44 have been observed for the first time. The states have been identified through recoil-gamma-gamma coincidences and comparison with analogue states in the mirror nucleus Sc-44. Mirror energy differences have been extracted and compared to state-of-the-art fp shell-model calculations which include charge symmetry breaking forces.
The aim of the present study is to cast some light on the realisation of sj- and tj-sounds (/ɧ/ and /ɕ/) in Estonian Swedish. These sounds are said not to occur in this variety of Swedish, or to have a different realisation as compared to Standard Swedish (Lagman, 1979). Our analysis, based on repetitions of elicited words produced by five elderly speakers of Estonian Swedish, shows that sj- and t
We report on magnetotransport measurements of nanoconstricted (Ga, Mn) As devices showing very large resistance changes that can be controlled by both an electric and a magnetic field. Based on the bias voltage and temperature-dependent measurements down to the millikelvin range we compare the models currently used to describe transport through (Ga, Mn) As nanoconstrictions. We provide an explanat
Background: The Freezing of Gait Questionnaire (FOGQ) was developed in response to the difficulties of observing and quantifying freezing of gait (FOG) clinically as well as in laboratory settings. However, as the FOGQ is a clinician-administered patient-reported rating scale it cannot be used in postal surveys. Here we report the development and measurement properties of a self-administered versi
Efforts by the European Commission and by leading member states, to normatively frame the debate about trade - and thus rhetorically entrap other actors by references to previous commitments - are ubiquitous; and member states do take account of the potential effects of their actions, in terms of potential praise or shaming, and adapt their behaviour to the institutional setting. However, this hol
Low bone volume and changes in bone quality or microarchitecture may predispose individuals to fragility fractures. As the dominant component of the human skeleton, cortical bone plays a key role in protecting bones from fracture. However, histological investigations of the underlying structural changes, which might predispose to fracture, have been largely limited to the cancellous bone. The aim
OBJECTIVES: To investigate the distribution of the transient receptor potential (TRP) A1 ion channel in the rat urinary bladder, and to study the effects of hydrogen sulfide (H(2)S) and known TRPA1 activators on micturition in conscious rats and on heterologously expressed ion channels. METHODS: The expression of TRPA1 in urinary bladder was studied with fluorescence immunohistochemistry and real-
Popular Abstract in Swedish Folkligt deltagande är något av en paroll i dagens utvecklingstänkande. När människor deltar i beslutsfattande och samhällsplanering på lokal nivå blir resultatet bättre och mer anpassat till lokala behov, särskilt i jämförelse med expertorienterade och centraliserade utvecklingsstrategier. Samtidigt kräver detta att folk i allmänhet vill delta och de har ett intresse aThe emphasis on people-centred development is distinctive in today’s development discourse. This is noticeable in catchwords like democratic decentralisation, participation, and empowerment, which are highly esteemed among NGOs, donors, and policymakers in recipient countries. The benefits of participatory approaches are several. When people influence the process of development, policies and pr
Popular Abstract in Swedish Denna studie omfattar tidsperioderna ordovicium, silur och äldsta devon. Silurperioden sträcker sig från 444 till 416 miljoner år sedan och karakteriseras av globala miljö- och klimatförändringar. Vid denna tid hade djur och växter börjat kolonisera land, land som tidigare varit ödsligt och kargt. Min studie visar att det i Skåne då redan fanns en flora bestående av priThe Silurian through earliest Devonian, between ca 444 and 412 million years ago, was characterized by significant changes in global climate and environment. At that time, plants and animals had begun to expand the colonization of previous relatively desolate terrestrial landscape. Macrofossils of land plants are very rare from this period because these early land plants lacked large and robust ti
