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In this Letter, we use a discrete polarizable solvation model for a systematic analysis of the solvent effects on the nitrogen NMR shielding and nuclear quadrupole coupling constants in a series of 1-methyltriazoles. Fairly accurate predictions are found for the solvent shifts of the nitrogen NMR shielding constants. The analysis of the relative half-height widths of the resonance signal predicted
Osteoporosis is characterized by decreased bone mineral density (BMD) leading to reduced bone strength and increased fracture risk. Several heritable components affect a bone’s ability to resist fracture, including size, structure and strength; therefore identification of the genes underlying several bone characteristics will help elucidate the pathogenesis of fracture risk. Dissection of the gene
The ATLAS (A Toroidal LHC ApparatuS) Inner Detector provides charged particle tracking in the centre of the ATLAS experiment at the Large Hadron Collider (LHC). The Inner Detector consists of three subdetectors: the Pixel Detector, the Semiconductor Tracker (SCT), and the Transition Radiation Tracker (TRT). This paper summarizes the tests that were carried out at the final stage of SCT+TRT integra
Background: Models based on using perturbative polarization corrections and mean-field blocking approximation give conflicting results for masses of odd nuclei. Purpose: We systematically investigate the polarization and mean-field models, implemented within self-consistent approaches that use identical interactions and model spaces, to find reasons for the conflicts between them. Methods: For den
Organisms usually benefit from heterogeneous conditions, but, by doing so, may reduce the degree of heterogeneity. The question therefore arises how heterogeneity is maintained. We investigated within-year spatiotemporal patterns in a monospecific stand of a submerged plant (fennel pondweed, Potamogeton pectinatus), with the novelty that we distinguished between different forms of heterogeneity: s
Health assessment measurements for patients with Rheumatoid arthritis (RA) have to be meaningful, valid and relevant. A commonly used questionnaire for patients with RA is the Stanford Health Assessment Questionnaire Disability Index (HAQ), which has been available in Swedish since 1988. The HAQ has been revised and improved several times and the latest version is the Multi Dimensional Health Asse
Coordination of apical constriction in epithelial sheets is a fundamental process during embryogenesis. Here, we show that DRhoGEF2 is a key regulator of apical pulsation and constriction of amnioserosal cells during Drosophila dorsal closure. Amnioserosal cells mutant for DRhoGEF2 exhibit a consistent decrease in amnioserosa pulsations whereas overexpression of DRhoGEF2 in this tissue leads to an
Using the Swedish military enlistment test, this paper estimates the return to schooling for individuals belonging to different parts of the ability distribution. It also attempts to predict whether an endogenous test score causes bias in the "ability-specific" returns to schooling that varies with the test score. A significant finding is that a higher score in the test is associated with a higher
Background: Activating KRAS and BRAF mutations predict unresponsiveness to EGFR-targeting therapies in colorectal cancer (CRC), but their prognostic value needs further validation. In this study, we investigated the impact of KRAS codons 12 and 13, and BRAF mutations on survival from CRC, overall and stratified by sex, in a large prospective cohort study. Methods: KRAS codons 12 and 13, and BRAF m
We assessed the relative merits of two approaches for including polarization effects in classical force fields for the sulfate anion. One of the approaches is the explicit shell model for atomic polarization and the other is an implicit dielectric continuum representation of the electronic polarization, wherein the polarizability density is spatially uniform. Both the solvation and ion association
This paper analyzes the effects of the interaction between technology adoption and incomplete enforcement on the extent of violations and the rate of abatement technology adoption. We focus on price-based and quantity-based emission regulations. First, we show that in contrast to uniform taxes, under tradable emissions permits (TEPs), the fall in permit price produced by technology adoption reduce
BACKGROUND: Interventions aimed at reducing the number of smokers are generally believed to be cost effective. However as the cost of the interventions should be paid up front whereas the gains in life years only appear in the future--the budgetary consequences might be a barrier to implementing such interventions. AIMS: The aim of the present paper was to assess the long-term cost effectiveness
We carried out a combined study of UV-VUV luminescence and resonant x-ray emission from BeO single crystals with incident photon energies in the vicinity of the Be 1s absorption edge. The x-ray emission spectra show that at the Be 1s photoabsorption edge the lattice relaxation processes in the excitation site take place already on the timescale of the radiative decay of the core excitation. Compar
As one of two well-exposed intraoceanic arcs, the Talkeetna arc of Alaska affords an opportunity to understand processes deep within arcs. This study reports new Lu-Hf and Sm-Nd garnet ages, Ar-40/Ar-39 hornblende, mica and whole-rock ages, and U-Th/He zircon and apatite ages from the Chugach Mountains, Talkeetna Mountains, and Alaska Peninsula, which, in conjunction with existing geochronology, c
Asymmetrical flow field-flow fractionation (AF4) is rapidly becoming a technique of choice for the separation and characterization of complex materials. It is capable of fractionating samples over a wide size (similar to 2 nm to 50 mu m in diameter) and molecular weight range (10(3)-10(10) g/mol). It offers gentle, low shear, low pressure separation conditions which are essential to preserve the s
Abstract This dissertation examines the function of metaphor and simile in Cicero’s dialogue De senectute. For this purpose, it employs Lakoff-Johnsonian metaphor theory and compares the metaphorical concepts that the scholars of that tradition have found in English with the metaphors found in Cicero’s text. Many languages are being investigated today by scholars who use this theory, and differen
CdTe semiconductor nanocrystals were synthesized with three different stabilizers: Mercaptoacetic Acid (MM), Mercaptopropionic Acid (MPA) and 2-Mercaptoethanol (ME) at pH approximate to 11.2 by wet chemical route using potassium tellurite and cadmium chloride as starting materials. The effect of capping agent on the preparation of these samples was evaluated using UV-Visible absorption and photolu
