Search results

Popular Abstract in Swedish Neuoroblastom är en av de tumörformer som oftast drabbar små barn. Eftersom tumörer lyckligtvis är relativt ovanliga hos barn drabbas inte fler än i genomsnitt 14 barn årligen av neuroblastom i Sverige. Tyvärr finns dock, trots den effektiva behandling som kunnat arbetas fram för många andra barncancerformer, idag ingen verksam behandling att tillgå för så många som hälNeuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f

The present contribution describes some simulations of the observation of binaries with GAIA. The results do not differ fundamentally from earlier estimates, e.g. in GAIA's Concepts and Technology Study Report (ESA-2000-SCI-4), but they are based on more realistic assumptions and much more extensive numerical work.

Popular Abstract in Swedish MHC upptäcktes för 60 år sedan då George Snell konstaterade att möss som var genetiskt lika inte stötte bort transplanterad hud medan genetiskt olika möss gjorde det. Men det var inte förrän långt senare som man insåg vilken roll som MHC spelar i immunförsvaret hos alla vertebrater. Sedan ett par decennier tillbaka är detta ett välstuderat område speciellt hos människanIn birds the major histocompatibility complex (MHC) organization differs both among and within orders. Galliformes often have simple arrangements with few transcribed MHC genes whilst many songbirds (Passeriformes) have a complex arrangement with many MHC genes and also presence of pseudo-genes. In this thesis I have partly characterized MHC class I in house sparrows (Passer domesticus), sequencin

The desert locust, Schistocerca gregaria, is a polymorphic insect that occurs in two morphological and physiological distinct phases, solitary and gregarious, depending on population density. The two phases are reversible at any developmental stage. The gregarious phase produces and uses stage-specific pheromones, that keep the swarm together. In my thesis, I investigated the functional morphology

Abstract is not available

Wireless access technologies such as UMTS with HSPA extensions, WiMAX, and Flash-OFDM and the convergence towards next generation heterogeneous networks enable the realization of always best connected scenarios. As the resulting heterogeneous networks become easier to access and more reliable to depend on, novel telemedicine services such as vehicular emergency applications emerge. Due to their li

Abstract. The essay aims at integration of different concepts of meaning developed in semiotics, biology, and cognitive science, in a way that permits the formulation of issues involving evolution and development. The concept of sign in semiotics, just like the notion of representation in cognitive science, have either been used so broadly as to become almost meaningless, or they have been outrigh

Requirements Engineering and Testing are considered inseparable and together enable successful projects. One could make a statement that serious negligence of any of the two will bring catastrophic consequences for the project, delays, failures and unhappy customers. Thus, alignment and cooperation between the two are not only recommended but highly required for contemporary complex software and s

In order to stay competitive and meet the changing needs of the market, construction firms must develop efficient means of gathering and using knowledge of end-users requirements. This study uses two case studies, to explore the knowledge creation of end-users requirements in project driven firms. The focus of the study is the interface between firm and project. The interface is analyzed from both

Popular Abstract in Swedish SVENSK SAMMANFATTNING Den kliniska effekten av läkemedel som administreras till näsa eller lunga beror på läkemedlets egenskaper och på dess lokala deposition. Depositionsstudier är därför värdefulla för att kunna karakterisera olika beredningar. Depositionen påverkas av partiklarnas storlek och hastighet, genom att stora partiklar med hög hastighet ger upphov till en hThe local deposition, pharmacokinetics, and systemic activity of inhaled and intranasal glucocorticosteroids in different formulations and devices(ICSs) has been investigated. After nasal administration of the ICS budesonide (Bud), the systemic availability (F) was found to be significantly higher from an aqueous pump spray and from the powder inhaler Turbuhaler, than from a pressurized metered do

The possibility of using the channel reciprocity between the uplink and downlink channels in Frequency Division Duplex (FDD) systems to improve the efficiency has been deeply investigated. Previous studies have come to different conclusions for the characterization of the dissimilarity in uplink and downlink channel properties. This paper analyzes the mismatch in directional properties of the upli

Popular Abstract in Undetermined Vårt immunförsvar består av molekyler, celler, och barriärer som har till uppgift att hålla oss friska genom att avlägsna eller stänga ute virus och skadliga mikroorganismer. På alla kärnförsedda celler i vår kropp sitter en stor mängd MHC klass I-molekyler, strukturer som kan liknas vid korgar. I varje korg ligger en peptid som är ett fragment av något som finns iHuman leukocyte antigen class I (HLA-I) molecules are present on all nucleated cells and present the cell content to cytotoxic T lymphocytes in the form of peptides. Maturation of HLA-I occurs in the endoplasmic reticulum and results in stable peptide-HLA-I complexes, in the presence of proper quality control. For proper peptide binding most HLA-I molecules interact with the peptide-loading comple

Mitochondrial permeability transition (MPT) is induced in isolated brain mitochondria by calcium and oxidants and is inhibited by adenine nucleotides. When induced, MPT is associated with equilibration of solutes of <1500 Da across the inner mitochondrial membrane. A persistent induction of MPT depolarizes the inner membrane and causes cessation of ATP synthesis, swelling of the matrix, and bursti

This doctoral thesis has its theoretical origin in the notion that the information flow between management teams, financial analysts and investors is especially exposed to information asymmetry when knowledge-intense companies are concerned. Information asymmetry may aggravate agency problems and risk causing an impairment of the efficient allocation of capital on the stock market. Therefore, the