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The stringent response, controlled by (p)ppGpp, enables bacteria to trigger a strong phenotypic resetting that is crucial to cope with adverse environmental changes and is required for stress survival and virulence. In the bacterial cell, (p)ppGpp levels are regulated by the concerted opposing activities of RSH (RelA/SpoT homologue) enzymes that can transfer a pyrophosphate group of ATP to the 3′

The interplay between international policies and the interests and internal pressures of the state is examined in the context of project‐based community participation in urban shelter provision in Egypt. Three contrasting upgrading projects are used. Using the concept of interest mediation, the paper argues that, whilst the state may be receptive to external pressure for community participation, t

Although the US and NATO invasion of Afghanistan in 2001 was ideologically justified under the banner of democracy and women’s rights, the latter issue has been completely forgotten within the public sphere since then. As the war has officially ended in Afghanistan, new forms of misogyny and sexual and gender-based violence (SGBV) have arisen. The ‘post-war’ Afghan context presents an institutiona

As we write this chapter about reinterpreting women’s roles in peacebuilding, Colombia is at a turning point. On November 24, 2016, the Revolutionary Armed Forces of Colombia—People’s Army (FARC-EP) and the national government signed a historical agreement that ended the 60-year-long armed conflict. How this peace and the social reconciliation that it requires will be implemented remain to be seen

This paper is a theoretical contribution to interrogate and elucidate a term commonly used (but rarely interrogated) from the perspective of the economic geography field within which we work: peripheries. As researchers of “peripheries” we are all too familiar with the fuzziness and problematic nature of this term, and our long-standing research agenda is to work towards clarifying and nuancing it

Anisotropic particles are known to exhibit a richer and more complex phase behavior in comparison to their spherical counterpart. While the majority of the existing studies address structural properties, the dynamic behavior of anisotropic particles is a relatively lesser explored avenue. Using multispeckle ultra-small-angle x-ray photon correlation spectroscopy (USA-XPCS), we have carried out a s

Noise from the wheel-rail interface is a troublesome side effect when railway vehicles negotiate rail curves. In this laboratory study, two pin-on-disc tribometers were used to simulate the pure sliding process in the wheel-rail contact. The purpose was to investigate the relationships between surface topographies, tribological aspects and the emitted noise. Five different surface topographies man

The coefficient of friction between railway wheels and rails is crucial to the railway adhesion, further greatly affecting railway operation and maintenance. Since the wheel-rail system is an open system, the coefficient of friction is significantly influenced not only by various types of contaminants but also by environmental conditions. This paper conducted a set of pin-on-disc tests measuring t

Context. We present a systematic X-ray spectral-timing study of the recently discovered, exceptionally bright black hole X-ray binary system MAXI J1820+070. Our analysis focuses on the first part of the 2018 outburst, covering the rise throughout the hard state, the bright hard and hard-intermediate states, and the transition to the soft-intermediate state. Aims. We address the issue of constraini

Contemporary smart cities have largely mirrored the sustainable development agenda by embracing an ecological modernisation approach to urban development. There is a strong focus on stimulating economic activity and environmental protection with little emphasis on social equity and the human experience. The health and well-being agenda has potential to shift the focus of smart cities to centre on

DLK1 is a maternally imprinted, paternally expressed gene coding for the transmembrane protein Delta-like homologue 1 (DLK1), a non-canonical NOTCH ligand with well-described roles during development, and tumor-supportive functions in several aggressive cancer forms. Here, we review the many functions of DLK1 as a regulator of stem cell pools and tissue differentiation in tissues such as brain, mu

The Rich Kids of Instagram (RKOI) portray luxury lifestyles on social media. The potential roles of travel and transport within these online displays of affluence have not yet been examined. This paper’s purpose is to analyse how transport modes and luxury travel are depicted and interrelated through RKOI images. Co-occurrence analyses were conducted using a data set of Instagram posts with RKOI a

This article argues that the development of regional innovation concepts, drawing primarily on the experiences of advanced regions, has led to inadequate narratives about the experience of less-developed regions (LDRs). Drawing on the extensive experience of the authors doing research in LDRs, the article develops three main arguments: first it examines the limitations of endogenous approaches to

The use of low-cost immersive virtual reality systems is rapidly expanding. Several studies started to analyse the accuracy of virtual reality tracking systems, but they did not consider in depth the effects of external interferences in the working area. In line with that, this study aimed at exploring the static-positional accuracy and the robustness to occlusions inside the capture volume of the