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The PNPLA3 I148M variant is the major genetic risk factor for all stages of fatty liver disease, but the underlying pathophysiology remains unclear. We studied the effect of this variant on hepatic metabolism in homozygous carriers and non-carriers under multiple physiological conditions with state-of-the-art stable isotope techniques. After an overnight fast, carriers had higher plasma β-hydroxyb

Commencing from the question “what makes mysticism feminine?” (a medical-historical conception of female bodies being receptive to some forms of mystical experiences? following an idea of gendered embodiment, a specific feminine spiritual corporeality?), the presence of forms of violence preceding the beatification or sanctification of women as victim souls caught my attention.Examples like Laura

This article examines two of the most canonical plays in all of Scandinavian and European modern drama – Henrik Ibsen’s Hedda Gabler (1890) and August Strindberg’s A Dream Play (1902) – through the prism of the history of knowledge. The primary claim of the article is that these two plays are paradigmatic literary representations and critiques of one of the main historical processes pertaining to

Background: The open abdomen is an innovation that greatly improved surgical understanding of damage control, temporary abdominal closure, staged abdominal reconstruction, viscera and enteric fistula care, and abdominal wall reconstruction. This article provides an evidence-informed, expert, comprehensive narrative review of the open abdomen in trauma, acute care, and vascular and endovascular sur

Academic debates on law and society relations in authoritarian regimes continue to revolve around issues of the dysfunctional legal system, corruption and informality, clientelistic legal culture, and how the authoritarian regimes in this region deploy law as a means for suppressing dissent. However, in this article, we argue that the legal landscape of authoritarian regimes should not be viewed f

Objective: The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years. Methods: A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the European Pr

Context. To take full advantage of upcoming large-scale spectroscopic surveys, it will be necessary to parameterize millions of stellar spectra in an efficient way. Machine learning methods, especially convolutional neural networks (CNNs), will be among the main tools geared at achieving this task. Aims. We aim to prepare the groundwork for machine learning techniques for the next generation of sp

Background: Lead exposure is associated with cardiovascular disease. Atherosclerosis has been hypothesized to be one of the underlying mechanisms behind this association. Aim: To investigate whether lead exposure is associated with an increased risk of atherosclerosis in the carotid arteries in a large Swedish population-based cohort. Methods: We performed a cross-sectional study using data from t

Teachers in the aesthetic program in upper secondary school in Sweden have identified that there are great opportunities and challenges in teaching and working with students who have EDI as their main instrument. From a student perspective it has relevance to being part of meaningful music education developing their musical identity. Students playing EDI can explore an array of electronical musica

Abstract in FrenchLa question qui m’occupe dans cet article est de savoir si une synagogue du premier siècle, comprise à la fois comme une structure construite à cet effet et une institution formelle d’assemblée, se trouvait autrefois à Capharnaüm sous le site de la dernière synagogue en calcaire. J’évalue la question à frais nouveaux en apportant une réflexion méthodologique dans la perspective dThe question with which I am centrally concerned in this article is whether a first-century synagogue, understood as both a purpose-built structure and a formal institution of assembly, once stood in Capernaum beneath the site of its later limestone synagogue. I assess the question anew by providing methodological reflection from the perspective of Collingwoodian critical historiography. In sectio

Mark. Z Danielewski is known for his experiments with the aesthetics of print in works such as House of Leaves and The Familiar. The chapter examines what happens when the experimental book object is digitalized, focusing on the enhanced e-book version of Danielewski’s The Fifty Year Sword. Drawing on theories on remediation (Bolter and Grusin), bookishness (Pressman, Hayles) and digital materiali

In this essay, I offer the first sustained scholarly discussion of the Know Yourself Skeleton Mosaic (KYSM) within its broader cultural milieu and of its contribution to our understanding of self-knowledge in antiquity. In many ways, the mosaic represents an innovative visual "blend" of several cultural tropes and symbols known from the Greco-Roman world. For example, only here is the concept of s

This open access book introduces a groundbreaking concept - civil society elites - and serves as an essential resource for scholars, researchers and students interested in the complexities of power and influence within contemporary civil societies. Through a series of unique empirical studies, the authors offer a comprehensive examination of the individuals occupying the upper echelons of influent

ObjectiveTo explore sex and age differences in Patient-Reported Outcomes Measures (PROMs) and adherence to digital osteoarthritis (OA) self-management intervention.MethodsA register-based study with data from an OA digital self-management intervention. PROMs and adherence were collected at baseline and/or 3 ​month follow-up: ‘pain intensity’ in hip/knee (best/worst: 0–10), ‘activity impairments' (

Environments contain various forms of noise that can interfere with the ability of animal sensory systems to perceive information. One ubiquitous type of visual noise in shallow aquatic habitats is caustic flicker (or caustics), consisting of dynamically moving light patterns caused by the refraction of light when passing through the water's rippling surface. While some teleost fish avoid environm

In this article, we put into question the discourses that emerged during the global financial crisis (GFC) and that coalesced around a particular socio-economic imaginary of ‘recovery’ over the period 2009–2012. Our reading of these discourses is very much guided by the notion of the dialectic as developed by Fredric Jameson, and as such this paper can be read as an attempt to put his theoretical