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The role of the cysteine thiolate ligand for the unusual copper coordination geometry in the blue copper proteins has been studied by comparing the electronic structure, geometry, and energetics of a number of small Cu(II) complexes. The geometries have been optimised with the density functional B3LYP method, and energies have been calculated by multi- configurational second-order perturbation the

The interaction of C-60 with the Au(111) surface has been investigated using synchrotron radiation-based electron spectroscopy. Resonant photoelectron spectroscopy and autoionization spectroscopy have been used to probe the coupling between the molecule and the substrate. Three distinct high energy spectator Auger features were observed that are only evident for a monolayer of C-60 chemisorbed to

OBJECTIVE: To examine the risk of prostate cancer in relation to pre-diagnostic serum levels of vitamin D (25OHD(2) and 25OHD(3)), PTH, and calcium. METHODS: Nine hundred forty-three incident prostate cancer cases were identified in the Malmö Diet and Cancer Study cohort, and each was matched with one control using incidence density matching with age as the underlying timescale. We also matche

AIM To study the value and reliability of an examination of neurological soft-signs, often used in Sweden, in the assessment of children with attentiondeficit– hyperactivity disorder (ADHD), by examining children with and without ADHD, as diagnosed by an experienced clinician using the DSM-III-R. METHOD We have examined interrater reliability (26males, nine females; age range 5y 6mo–11y), internal

Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes?

We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, there were 611 incident cases of primary, malignant,

In development, epigenetic mechanisms such as DNA methylation have been suggested to provide a cellular memory to maintain multipotency but also stabilize cell fate decisions and direct lineage restriction. In this study, we set out to characterize changes in DNA methylation and gene expression during granulopoiesis using 4 distinct cell populations ranging from the oligopotent common myeloid prog

Management of foot ulcer in individuals with diabetes remains a major therapeutic challenge throughout the world. We performed a critical review of evidence of present and new techniques and devices in the treatment of diabetic foot ulcer. The golden standard for optimal evidence in the Cochrane system is level I randomized controlled trials, and meta-analyses of several randomized controlled tria

We discuss different nonequilibrium mechanisms by which bulk aggregates directly modify, and can even control, the interfacial structure and morphology of an oppositely charged polyelectrolyte/surfactant (P/S) mixture. Samples are categorized at the air/water interface with respect to the dynamic changes in the bulk phase behavior, the bulk composition, and the sample history using complementary s

This study reports the early and midterm to long-term experience of chimney grafts (CGs) in urgent endovascular repair of complex lesions in the thoracic aorta.

Aims: During cell death, energy-consuming cell degradation and recycling programs are performed. Maintenance of energy-delivery during cell death is therefore crucial but the mechanisms to keep the mitochondrial functions intact during these processes are poorly understood. We have investigated the hypothesis that the heme- and radical-binding ubiquitous protein A1M (α₁-microglobulin) i

BACKGROUND & AIMS: There has been consistent evidence for a relationship between smoking and colorectal cancer (CRC), although it is not clear whether the colon or rectum is more sensitive to the effects of smoking. We investigated the relationships between cigarette smoking and risk of CRC and tumor location. METHODS: We analyzed data from 465,879 participants in the European Prospective Inve

How do political parties arrive at their policy positions? We conceptualize position formation in federalist countries as an intra-party bargaining process in which subnational parties compete with each other in an attempt to get their own positions into their national party manifesto. Drawing on theories about inter-party bargaining over ministerial portfolios, we hypothesize that the bargaining

We investigated associations between metabolic factors and blood cancer subtypes. Data on body mass index (BMI), blood pressure, blood glucose, total cholesterol, and triglycerides from seven prospective cohorts were pooled (n = 578,700; mean age = 44 years). Relative risks of blood cancers were calculated from Cox regression models. During mean follow-up of 12 years, 2,751 incident and 1,070 fata

Objective: To assess associations and genotype x treatment interactions for melanocortin 4 receptor (MC4R) locus variants and obesity-related traits. Design and Methods: Diabetes prevention program (DPP) participants (N = 3,819, of whom 3,356 were genotyped for baseline and 3,234 for longitudinal analyses) were randomized into intensive lifestyle modification (diet, exercise, weight loss), metform

Various samples of the solid solution Gd2NixCu2-xMg were synthesized from the elements in sealed tantalum ampoules in an induction furnace. All members crystallize with the tetragonal Mo2FeB2 type structure, space group P4/mbm, and they were characterized on the basis of Guinier powder patterns and energy dispersive X-rays analyses. The lattice parameters decrease with increasing nickel content in

Precision agriculture requires detailed crop status information at high spatial and temporal resolutions. Remote sensing can provide such information, but single sensor observations are often incapable of meeting all data requirements. Spectral-temporal response surfaces (STRSs) provide continuous reflectance spectra at high temporal intervals. This is the first study to combine multispectral sate